Entity Details

Primary name SPY2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43597
EntryNameSPY2_HUMAN
FullNameProtein sprouty homolog 2
TaxID9606
Evidenceevidence at protein level
Length315
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesSPRY2

GO terms

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GOName
GO:0000132 establishment of mitotic spindle orientation
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0007605 sensory perception of sound
GO:0008285 negative regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0015629 actin cytoskeleton
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0016525 negative regulation of angiogenesis
GO:0019901 protein kinase binding
GO:0030291 protein serine/threonine kinase inhibitor activity
GO:0030335 positive regulation of cell migration
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031345 negative regulation of cell projection organization
GO:0031397 negative regulation of protein ubiquitination
GO:0032587 ruffle membrane
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034260 negative regulation of GTPase activity
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042472 inner ear morphogenesis
GO:0043066 negative regulation of apoptotic process
GO:0043407 negative regulation of MAP kinase activity
GO:0043539 protein serine/threonine kinase activator activity
GO:0045165 cell fate commitment
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048513 animal organ development
GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway
GO:0051897 positive regulation of protein kinase B signaling
GO:0060437 lung growth
GO:0060449 bud elongation involved in lung branching
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
GO:1902747 negative regulation of lens fiber cell differentiation
GO:1990752 microtubule end
GO:1990830 cellular response to leukemia inhibitory factor

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR007875 SproutyFamilyFamily
IPR030780 Protein sprouty homologue 2FamilyFamily

Diseases

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Disease IDSourceNameDescription
616818 OMIMIgA nephropathy 3 (IGAN3)A form of IgA nephropathy, a common primary glomerulonephritis characterized by glomerular sclerosis, interstitial fibrosis, and mesangial glomerular deposits of immunoglobulin A and immunoglobulin G visible on renal biopsies. IgA nephropathy is associated with renal insufficiency that can progress to end-stage renal disease. Proteinuria and hematuria are characteristic clinical presentations. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

122 interactions

InteractorPartnerSourcesPublicationsLink
SPY2_HUMANTRI51_HUMANBioGRID, HPRD, IntAct16189514 details
SPY2_HUMANGRIN2_HUMANBioGRID, HPRD, IntAct16189514 details
SPY2_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct16189514 details
SPY2_HUMANATL4_HUMANBioGRID, HPRD, IntAct16189514 details
SPY2_HUMANPLS1_HUMANBioGRID, HPRD, IntAct16189514 details
SPY2_HUMANKR412_HUMANBioGRID, HPRD, IntAct16189514 25416956 details
SPY2_HUMANGRB2_HUMANBioGRID, HPRD, MINT10940627 12402043 15004239 16893902 17255109 17974561 32296183 details
SPY2_HUMANCBL_HUMANBioGRID, HPRD, MINT11053437 11983899 12234920 12593795 12593796 12815057 15004239 15962011 16246327 16479008 16893902 17255109 17974561 18273061 20124286 20461437 20622121 20877636 21596750 details
SPY2_HUMANSH3K1_HUMANBioGRID, MINT15962011 25416956 32296183 details
SPY2_HUMANOTX1_HUMANBioGRID, IntAct, MINT21516116 25416956 details
SPY2_HUMANUBS3A_HUMANBioGRID, IntAct, MINT21516116 25416956 32296183 details
SPY2_HUMANRTF2_HUMANBioGRID, MINT21900206 details
SPY2_HUMANF219A_HUMANBioGRID, MINT21900206 details
SPY2_HUMANCRIP2_HUMANBioGRID, MINT21900206 details
SPY2_HUMANDPYL1_HUMANBioGRID, MINT21900206 details
SPY2_HUMANCYTB_HUMANBioGRID, MINT21900206 details
SPY2_HUMANCATB_HUMANBioGRID, MINT21900206 details
SPY2_HUMANDYN2_HUMANBioGRID, MINT21900206 details
SPY2_HUMANFBN1_HUMANBioGRID, MINT21900206 details
SPY2_HUMANNR1H2_HUMANBioGRID, MINT21900206 details
SPY2_HUMANNUBP1_HUMANBioGRID, MINT21900206 details
SPY2_HUMANSDHB_HUMANBioGRID, MINT21900206 details
SPY2_HUMANSEM5B_HUMANBioGRID, MINT21900206 details
SPY2_HUMANUBR1_HUMANBioGRID, MINT21900206 details
SPY2_HUMANZBT16_HUMANBioGRID, MINT21900206 details
SPY2_HUMANZN266_HUMANBioGRID, MINT21900206 details
SPY2_HUMANKDM1A_HUMANBioGRID, MINT23455924 details
SPY2_HUMANTNS2_HUMANBioGRID, IntAct25814554 details
SPY2_HUMANFRS3_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANMEOX2_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANGRAP2_HUMANBioGRID, IntAct25416956 32296183 details
SPY2_HUMANMDFI_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANSPY1_HUMANBioGRID, IntAct15004239 25416956 details
SPY2_HUMANNCK2_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANAAKB2_HUMANBioGRID, IntAct24722188 25416956 32296183 details
SPY2_HUMANMABP1_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANIF4E2_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANSTK16_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANGPIX_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANKRA59_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANAQP1_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANKR105_HUMANIntAct25416956 details
SPY2_HUMANKR108_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANKR109_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANKR10B_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANCREB5_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANMTG8_HUMANBioGRID, IntAct25416956 32296183 details
SPY2_HUMANPE2R3_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANLASP1_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANLONF1_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANLCE3C_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANLCE3E_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANLCE1B_HUMANBioGRID, IntAct25416956 29892012 31515488 details
SPY2_HUMANLCE4A_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANLCE2D_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANKRA56_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANZDH17_HUMANBioGRID, IntAct24705354 25416956 26186194 28514442 details
SPY2_HUMANCTSR1_HUMANBioGRID, IntAct25416956 32296183 details
SPY2_HUMANZN417_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANUBS3B_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANATRIP_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANHEXI2_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANZN587_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANKRA94_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANKRA92_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANKR411_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANKRA47_HUMANIntAct25416956 details
SPY2_HUMAN3BHS7_HUMANBioGRID, IntAct21516116 25416956 details
SPY2_HUMANCHRD_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANSHFL_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANFAIM1_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANTRIM1_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANPACN3_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANGLCNE_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANUBP20_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANTCAF1_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANSPY2_HUMANBioGRID, IntAct25416956 details
SPY2_HUMANKIF1A_HUMANBioGRID, IntAct24722188 details
SPY2_HUMANACHG_HUMANBioGRID, IntAct25910212 details
SPY2_HUMANGRN_HUMANBioGRID, IntAct25910212 details
SPY2_HUMANSIAH2_HUMANBioGRID16888801 details
SPY2_HUMANNEDD4_HUMANBioGRID19864419 details
SPY2_HUMANITSN1_HUMANBioGRID22558309 details
SPY2_HUMANVPS25_HUMANBioGRID21543492 details
SPY2_HUMANVPS36_HUMANBioGRID21543492 details
SPY2_HUMANMKNK1_HUMANBioGRID16479008 details
SPY2_HUMANDGCR6_HUMANBioGRID24722188 details
SPY2_HUMANAF17_HUMANBioGRID25416956 details
SPY2_HUMANTXND5_HUMANBioGRID25416956 details
SPY2_HUMANKR101_HUMANBioGRID25416956 details
SPY2_HUMANKR103_HUMANBioGRID25416956 details
SPY2_HUMANTM14B_HUMANBioGRID21516116 details
SPY2_HUMANBRAF_HUMANBioGRID19690147 details
SPY2_HUMANKPCD_HUMANBioGRID19458088 details
SPY2_HUMANKPCD1_HUMANBioGRID19458088 details
SPY2_HUMANFBX7_HUMANBioGRID27503909 details
SPY2_HUMANHNRLL_HUMANBioGRID26871637 details
SPY2_HUMANHXA1_HUMANBioGRID32296183 details
SPY2_HUMANBAG3_HUMANBioGRID32296183 details
SPY2_HUMANM21D2_HUMANBioGRID32296183 details
SPY2_HUMANLCE1A_HUMANBioGRID32296183 details
SPY2_HUMANLCE1C_HUMANBioGRID32296183 details
SPY2_HUMANLCE1F_HUMANBioGRID32296183 details
SPY2_HUMANFXR1_HUMANMINT21653829 details
SPY2_HUMANFXR2_HUMANMINT21653829 details
SPY2_HUMANNUFP2_HUMANMINT21653829 details
SPY2_HUMANRAF1_HUMANBioGRID, HPRD12717443 details
SPY2_HUMANTESK1_HUMANBioGRID17974561 details
SPY2_HUMANPP2AA_HUMANBioGRID17255109 17974561 details
SPY2_HUMANEGLN2_HUMANBioGRID22006925 details
SPY2_HUMANEGLN1_HUMANBioGRID22006925 details
SPY2_HUMANEGLN3_HUMANBioGRID22006925 details
SPY2_HUMANVHL_HUMANBioGRID22006925 details
SPY2_HUMANRASH_HUMANBioGRID18048363 details
SPY2_HUMAN2AAA_HUMANBioGRID17255109 details
SPY2_HUMANHGS_HUMANBioGRID17320394 details
SPY2_HUMANSPY4_HUMANBioGRID15004239 details
SPY2_HUMANFRS2_HUMANBioGRID15004239 details
SPY2_HUMANHIF1A_HUMANBioGRID27281823 details
SPY2_HUMANPTN11_HUMANHPRD15031289 details
SPY2_HUMANCBLC_HUMANHPRD12234920 details
SPY2_HUMANCBLB_HUMANHPRD11053437 details