Entity Details

Primary name OREX_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43612
EntryNameOREX_HUMAN
FullNameOrexin
TaxID9606
Evidenceevidence at protein level
Length131
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesHCRT

GO terms

Show/Hide Table
GOName
GO:0001659 temperature homeostasis
GO:0005184 neuropeptide hormone activity
GO:0005576 extracellular region
GO:0005791 rough endoplasmic reticulum
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007268 chemical synaptic transmission
GO:0008021 synaptic vesicle
GO:0008156 negative regulation of DNA replication
GO:0030141 secretory granule
GO:0030431 sleep
GO:0031771 type 1 hypocretin receptor binding
GO:0031772 type 2 hypocretin receptor binding
GO:0042594 response to starvation
GO:0042755 eating behavior
GO:0043267 negative regulation of potassium ion transport
GO:0046928 regulation of neurotransmitter secretion
GO:0048471 perinuclear region of cytoplasm
GO:0051928 positive regulation of calcium ion transport
GO:0051970 negative regulation of transmission of nerve impulse
GO:0051971 positive regulation of transmission of nerve impulse
GO:0060079 excitatory postsynaptic potential
GO:0098794 postsynapse
GO:0120162 positive regulation of cold-induced thermogenesis

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cytoplasmic vesicle
Rough endoplasmic reticulum

Domains

Show/Hide Table
DomainNameCategoryType
IPR001704 Prepro-orexinFamilyFamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
161400 OMIMNarcolepsy 1 (NRCLP1)Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. The disease is caused by variants affecting the gene represented in this entry. Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients.

Drugs

Show/Hide Table
DrugNameSourceType
DB03088 Pidolic acidDrugbanksmall molecule

Interactions

4 interactions