Entity Details

Primary name PARP4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UKK3
EntryNamePARP4_HUMAN
FullNameProtein mono-ADP-ribosyltransferase PARP4
TaxID9606
Evidenceevidence at protein level
Length1724
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesPARP4

GO terms

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GOName
GO:0003677 DNA binding
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0006281 DNA repair
GO:0006464 cellular protein modification process
GO:0006471 protein ADP-ribosylation
GO:0006954 inflammatory response
GO:0006974 cellular response to DNA damage stimulus
GO:0008219 cell death
GO:0016020 membrane
GO:0019899 enzyme binding
GO:0042493 response to drug
GO:0051972 regulation of telomerase activity
GO:0070062 extracellular exosome
GO:0140289 protein mono-ADP-ribosylation
GO:1990404 protein ADP-ribosylase activity
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001357 BRCT domainDomainDomain
IPR002035 von Willebrand factor, type ADomainDomain
IPR004102 Poly(ADP-ribose) polymerase, regulatory domainDomainDomain
IPR012317 Poly(ADP-ribose) polymerase, catalytic domainDomainDomain
IPR013694 VIT domainDomainDomain
IPR031273 Protein mono-ADP-ribosyltransferase PARP4FamilyFamily
IPR036420 BRCT domain superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily
IPR036616 Poly(ADP-ribose) polymerase, regulatory domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
PARP4_HUMANSMAD3_HUMANBioGRID, IntAct21988832 details
PARP4_HUMANTCPZ_HUMANBioGRID, IntAct23414517 details
PARP4_HUMANMVP_HUMANBioGRID, HPRD, IntAct10477748 11855821 28514442 details
PARP4_HUMANTEP1_HUMANBioGRID15169895 details