Entity Details

Primary name HCN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UL51
EntryNameHCN2_HUMAN
FullNamePotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
TaxID9606
Evidenceevidence at protein level
Length889
SequenceStatuscomplete
DateCreated2003-02-28
DateModified2021-06-02

Ontological Relatives

GenesHCN2

GO terms

Show/Hide Table
GOName
GO:0005222 intracellular cAMP-activated cation channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007267 cell-cell signaling
GO:0008076 voltage-gated potassium channel complex
GO:0030552 cAMP binding
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0042802 identical protein binding
GO:0071320 cellular response to cAMP
GO:0071321 cellular response to cGMP
GO:0071805 potassium ion transmembrane transport
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0098719 sodium ion import across plasma membrane
GO:0098855 HCN channel complex
GO:1990573 potassium ion import across plasma membrane

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000595 Cyclic nucleotide-binding domainDomainDomain
IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERGFamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR013621 Ion transport N-terminalDomainDomain
IPR014710 RmlC-like jelly roll foldFamilyHomologous superfamily
IPR018488 Cyclic nucleotide-binding, conserved siteSiteConserved site
IPR018490 Cyclic nucleotide-binding-likeFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB02315 Cyclic GMPDrugbanksmall molecule
DB02527 Cyclic adenosine monophosphateDrugbanksmall molecule
DB09083 IvabradineDrugbanksmall molecule