Entity Details

Primary name CELA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UNI1
EntryNameCELA1_HUMAN
FullNameChymotrypsin-like elastase family member 1
TaxID9606
Evidenceevidence at protein level
Length258
SequenceStatuscomplete
DateCreated2001-10-18
DateModified2021-06-02

Ontological Relatives

GenesCELA1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0004252 serine-type endopeptidase activity
GO:0005615 extracellular space
GO:0006508 proteolysis
GO:0006954 inflammatory response
GO:0009791 post-embryonic development
GO:0016055 Wnt signaling pathway
GO:0031017 exocrine pancreas development
GO:0035264 multicellular organism growth
GO:0042127 regulation of cell population proliferation
GO:0045595 regulation of cell differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048771 tissue remodeling
GO:0060309 elastin catabolic process
GO:0061113 pancreas morphogenesis

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01844 N,N-dimethylformamideDrugbanksmall molecule
DB02114 CumidineDrugbanksmall molecule
DB02341 Mdl 101,146Drugbanksmall molecule
DB03202 2-[5-Methanesulfonylamino-2-(4-Aminophenyl)-6-Oxo-1,6-Dihydro-1-Pyrimidinyl]-N-(3,3,3-Trifluoro-1-Isopropyl-2-Oxopropyl)AcetamideDrugbanksmall molecule
DB03702 N-{4-[(Carboxymethyl)carbamoyl]benzoyl}-L-valyl-N-[(3S)-1,1,1-trifluoro-4-methyl-2-oxo-3-pentanyl]-L-prolinamideDrugbanksmall molecule
DB03757 N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-alanyl-L-alaninamideDrugbanksmall molecule
DB03890 N-[2-(1-Formyl-2-Methyl-Propyl)-1-(4-Piperidin-1-Yl-but-2-Enoyl)-Pyrrolidin-3-Yl]-MethanesulfonamideDrugbanksmall molecule
DB03925 FreselestatDrugbanksmall molecule
DB06951 (3R)-3-ethyl-N-[(4-methylphenyl)sulfonyl]-L-aspartic acidDrugbanksmall molecule
DB07433 (TERT-BUTYLOXYCARBONYL)-ALANYL-AMINO ETHYL-FORMAMIDEDrugbanksmall molecule
DB07955 (2-BROMOETHYL)(2-'FORMYL-4'-AMINOPHENYL) ACETATEDrugbanksmall molecule
DB07956 [1-(3-CHLORO-2-FORMYL-PHENYLCARBAMOYL)-2-METHYL-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTERDrugbanksmall molecule
DB07957 METHYL(2-ACETOXY-2-(2-CARBOXY-4-AMINO-PHENYL))ACETATEDrugbanksmall molecule
DB08007 (2R)-3-{[(BENZYLAMINO)CARBONYL]AMINO}-2-HYDROXYPROPANOIC ACIDDrugbanksmall molecule
DB08614 3-[[(METHYLAMINO)SULFONYL]AMINO]-2-OXO-6-PHENYL-N-[3,3,3-TRIFLUORO-1-(1-METHYLETHYL)-2-OXOPHENYL]-1(2H)-PYRIDINE ACETAMIDEDrugbanksmall molecule
DB08640 (2S,3S)-3-FORMYL-2-({[(4-METHYLPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACIDDrugbanksmall molecule
DB08641 (2S,3S)-3-FORMYL-2-({[(4-NITROPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACIDDrugbanksmall molecule