Entity Details

Primary name PLAP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y263
EntryNamePLAP_HUMAN
FullNamePhospholipase A-2-activating protein
TaxID9606
Evidenceevidence at protein level
Length795
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesPLAA

GO terms

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GOName
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006644 phospholipid metabolic process
GO:0006693 prostaglandin metabolic process
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0010992 ubiquitin recycling
GO:0016005 phospholipase A2 activator activity
GO:0016236 macroautophagy
GO:0032430 positive regulation of phospholipase A2 activity
GO:0043130 ubiquitin binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:0071222 cellular response to lipopolysaccharide
GO:1900045 negative regulation of protein K63-linked ubiquitination
GO:1903423 positive regulation of synaptic vesicle recycling
GO:1903861 positive regulation of dendrite extension
GO:2001224 positive regulation of neuron migration

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR013535 PUL domainDomainDomain
IPR015155 PLAA family ubiquitin binding domainDomainDomain
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily
IPR038122 PFU domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617527 OMIMNeurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies (NDMSBA)An autosomal recessive neurodevelopmental disorder characterized by progressive microcephaly, spastic quadriparesis, global developmental delay, profound mental retardation and severely impaired or absent motor function. More variable features include seizures and optic atrophy. The disease is caused by variants affecting the gene represented in this entry.