Entity Details

Primary name FYV1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y2I7
EntryNameFYV1_HUMAN
FullName1-phosphatidylinositol 3-phosphate 5-kinase
TaxID9606
Evidenceevidence at protein level
Length2098
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesPIKFYVE

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0005911 cell-cell junction
GO:0006612 protein targeting to membrane
GO:0006661 phosphatidylinositol biosynthetic process
GO:0008270 zinc ion binding
GO:0010008 endosome membrane
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0016887 ATP hydrolysis activity
GO:0019065 receptor-mediated endocytosis of virus by host cell
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030593 neutrophil chemotaxis
GO:0030670 phagocytic vesicle membrane
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0032288 myelin assembly
GO:0032438 melanosome organization
GO:0034504 protein localization to nucleus
GO:0035556 intracellular signal transduction
GO:0036289 peptidyl-serine autophosphorylation
GO:0042147 retrograde transport, endosome to Golgi
GO:0043231 intracellular membrane-bounded organelle
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
GO:0052810 1-phosphatidylinositol-5-kinase activity
GO:0090382 phagosome maturation
GO:0090385 phagosome-lysosome fusion
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903100 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1904562 phosphatidylinositol 5-phosphate metabolic process
GO:2000785 regulation of autophagosome assembly

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Early endosome membrane
Endosome membrane
Late endosome membrane

Domains

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DomainNameCategoryType
IPR000306 FYVE zinc fingerDomainDomain
IPR000591 DEP domainDomainDomain
IPR002423 Chaperonin Cpn60/TCP-1 familyFamilyFamily
IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, coreDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017455 Zinc finger, FYVE-relatedDomainDomain
IPR027409 GroEL-like apical domain superfamilyFamilyHomologous superfamily
IPR027410 TCP-1-like chaperonin intermediate domain superfamilyFamilyHomologous superfamily
IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminalFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR037378 PIKfyve, DEP domainDomainDomain
IPR043548 1-phosphatidylinositol-3phosphate-5-kinaseFamilyFamily

Diseases

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Disease IDSourceNameDescription
121850 OMIMCorneal dystrophy, fleck (CFD)A form of stromal corneal dystrophy characterized by numerous small white flecks scattered in all levels of the stroma, with configurations varying from semicircular to wreath-like, curvilinear, or punctate. Although CFD may occasionally cause mild photophobia, patients are typically asymptomatic and have normal vision. The disease is caused by variants affecting the gene represented in this entry.