Entity Details

Primary name NGN3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y4Z2
EntryNameNGN3_HUMAN
FullNameNeurogenin-3
TaxID9606
Evidenceevidence at protein level
Length214
SequenceStatuscomplete
DateCreated2002-03-27
DateModified2021-06-02

Ontological Relatives

GenesNEUROG3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007399 nervous system development
GO:0007417 central nervous system development
GO:0007422 peripheral nervous system development
GO:0021510 spinal cord development
GO:0030182 neuron differentiation
GO:0030855 epithelial cell differentiation
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0031018 endocrine pancreas development
GO:0031490 chromatin DNA binding
GO:0045666 positive regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:0048814 regulation of dendrite morphogenesis
GO:0060290 transdifferentiation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR032656 Neurogenin-3FamilyFamily
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
610370 OMIMDiarrhea 4, malabsorptive, congenital (DIAR4)A disease characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions