Entity Details

Primary name ANGL3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y5C1
EntryNameANGL3_HUMAN
FullNameAngiopoietin-related protein 3
TaxID9606
Evidenceevidence at protein level
Length460
SequenceStatuscomplete
DateCreated2002-11-08
DateModified2021-06-02

Ontological Relatives

GenesANGPTL3

GO terms

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GOName
GO:0001525 angiogenesis
GO:0004857 enzyme inhibitor activity
GO:0004859 phospholipase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0006071 glycerol metabolic process
GO:0006631 fatty acid metabolic process
GO:0006644 phospholipid metabolic process
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
GO:0007229 integrin-mediated signaling pathway
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0008203 cholesterol metabolic process
GO:0009395 phospholipid catabolic process
GO:0009725 response to hormone
GO:0009986 cell surface
GO:0010519 negative regulation of phospholipase activity
GO:0019915 lipid storage
GO:0030027 lamellipodium
GO:0030335 positive regulation of cell migration
GO:0030522 intracellular receptor signaling pathway
GO:0042632 cholesterol homeostasis
GO:0045766 positive regulation of angiogenesis
GO:0048844 artery morphogenesis
GO:0050996 positive regulation of lipid catabolic process
GO:0051004 regulation of lipoprotein lipase activity
GO:0051005 negative regulation of lipoprotein lipase activity
GO:0055088 lipid homeostasis
GO:0055090 acylglycerol homeostasis
GO:0055091 phospholipid homeostasis
GO:0062023 collagen-containing extracellular matrix
GO:0070328 triglyceride homeostasis

Subcellular Location

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Subcellular Location
Cell projection
Secreted

Domains

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DomainNameCategoryType
IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domainDomainDomain
IPR036056 Fibrinogen-like, C-terminalFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
605019 OMIMHypobetalipoproteinemia, familial, 2 (FHBL2)A disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides. The disease is caused by variants affecting the gene represented in this entry.