Entity Details

Primary name CLD16_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y5I7
EntryNameCLD16_HUMAN
FullNameClaudin-16
TaxID9606
Evidenceevidence at protein level
Length305
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesCLDN16

GO terms

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GOName
GO:0005198 structural molecule activity
GO:0005886 plasma membrane
GO:0005923 bicellular tight junction
GO:0006875 cellular metal ion homeostasis
GO:0007155 cell adhesion
GO:0007588 excretion
GO:0015095 magnesium ion transmembrane transporter activity
GO:0016021 integral component of membrane
GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
GO:0042802 identical protein binding
GO:0070830 bicellular tight junction assembly

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR003927 Claudin-16FamilyFamily
IPR004031 PMP-22/EMP/MP20/Claudin superfamilyFamilyFamily
IPR006187 ClaudinFamilyFamily
IPR017974 Claudin, conserved siteSiteConserved site

Diseases

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Disease IDSourceNameDescription
248250 OMIMHypomagnesemia 3 (HOMG3)A progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis. Recurrent urinary tract infections and kidney stones are often observed. In spite of hypercalciuria, patients do not show hypocalcemia. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB14513 MagnesiumSwissprotsmall molecule

Interactions

3 interactions