Entity Details

Primary name KLK4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y5K2
EntryNameKLK4_HUMAN
FullNameKallikrein-4
TaxID9606
Evidenceevidence at protein level
Length254
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesKLK4

GO terms

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GOName
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0006508 proteolysis
GO:0008236 serine-type peptidase activity
GO:0022617 extracellular matrix disassembly
GO:0030141 secretory granule
GO:0031214 biomineral tissue development
GO:0046872 metal ion binding
GO:0097186 amelogenesis

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
204700 OMIMAmelogenesis imperfecta, hypomaturation type, 2A1 (AI2A1)A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions