Entity Details

Primary name SI1L3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60292
EntryNameSI1L3_HUMAN
FullNameSignal-induced proliferation-associated 1-like protein 3
TaxID9606
Evidenceevidence at protein level
Length1781
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesSIPA1L3

GO terms

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GOName
GO:0001654 eye development
GO:0001725 stress fiber
GO:0002244 hematopoietic progenitor cell differentiation
GO:0003382 epithelial cell morphogenesis
GO:0005096 GTPase activator activity
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0007010 cytoskeleton organization
GO:0016324 apical plasma membrane
GO:0045177 apical part of cell
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0061689 tricellular tight junction
GO:0090162 establishment of epithelial cell polarity
GO:0090630 activation of GTPase activity

Subcellular Location

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Subcellular Location
Apical cell membrane

Domains

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DomainNameCategoryType
IPR000331 Rap/Ran-GAP domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR021818 Signal-induced proliferation-associated 1-like protein, C-terminalDomainDomain
IPR031204 Signal-induced proliferation-associated 1-like protein 3FamilyFamily
IPR035974 Rap/Ran-GAP superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616851 OMIMCataract 45 (CTRCT45)An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. The disease is caused by variants affecting the gene represented in this entry.