Entity Details

Primary name GSDME_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60443
EntryNameGSDME_HUMAN
FullNameGasdermin-E
TaxID9606
Evidenceevidence at protein level
Length496
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesGSDME

GO terms

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GOName
GO:0002839 positive regulation of immune response to tumor cell
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007605 sensory perception of sound
GO:0008219 cell death
GO:0008285 negative regulation of cell population proliferation
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0022829 wide pore channel activity
GO:0043410 positive regulation of MAPK cascade
GO:0060113 inner ear receptor cell differentiation
GO:0070265 necrotic cell death
GO:0070269 pyroptosis
GO:0071356 cellular response to tumor necrosis factor
GO:0098586 cellular response to virus
GO:0140507 granzyme-mediated programmed cell death signaling pathway
GO:1901612 cardiolipin binding
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR040460 Gasdermin, pore forming domainDomainDomain
IPR041263 Gasdermin, PUB domainDomainDomain
IPR042377 Gasdermin-EFamilyFamily

Diseases

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Disease IDSourceNameDescription
600994 OMIMDeafness, autosomal dominant, 5 (DFNA5)A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
GSDME_HUMANPTN_HUMANBioGRID, HPRD, IntAct16169070 details
GSDME_HUMANITBP1_HUMANBioGRID, IntAct23414517 details
GSDME_HUMANTIFA_HUMANBioGRID, IntAct32296183 details
GSDME_HUMANEGFR_HUMANBioGRID23956138 details