Entity Details

Primary name TLR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60603
EntryNameTLR2_HUMAN
FullNameToll-like receptor 2
TaxID9606
Evidenceevidence at protein level
Length784
SequenceStatuscomplete
DateCreated2002-01-31
DateModified2021-06-02

Ontological Relatives

GenesTLR2

GO terms

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GOName
GO:0071346 cellular response to interferon-gamma
GO:0002224 toll-like receptor signaling pathway
GO:0005794 Golgi apparatus
GO:0034123 positive regulation of toll-like receptor signaling pathway
GO:0001774 microglial cell activation
GO:0001875 lipopolysaccharide immune receptor activity
GO:0005887 integral component of plasma membrane
GO:0038023 signaling receptor activity
GO:0051607 defense response to virus
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0006955 immune response
GO:0034134 toll-like receptor 2 signaling pathway
GO:0010628 positive regulation of gene expression
GO:0032868 response to insulin
GO:0042802 identical protein binding
GO:0050765 negative regulation of phagocytosis
GO:0071726 cellular response to diacyl bacterial lipopeptide
GO:0004888 transmembrane signaling receptor activity
GO:0030670 phagocytic vesicle membrane
GO:0044877 protein-containing complex binding
GO:0046209 nitric oxide metabolic process
GO:0006915 apoptotic process
GO:0032570 response to progesterone
GO:0032741 positive regulation of interleukin-18 production
GO:0045121 membrane raft
GO:0001530 lipopolysaccharide binding
GO:0032722 positive regulation of chemokine production
GO:0050830 defense response to Gram-positive bacterium
GO:0070542 response to fatty acid
GO:0007252 I-kappaB phosphorylation
GO:0014005 microglia development
GO:0031226 intrinsic component of plasma membrane
GO:0044297 cell body
GO:0045087 innate immune response
GO:0052031 modulation by symbiont of host defense response
GO:0009986 cell surface
GO:0030667 secretory granule membrane
GO:0038187 pattern recognition receptor activity
GO:0042496 detection of diacyl bacterial lipopeptide
GO:0042995 cell projection
GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating
GO:0001666 response to hypoxia
GO:0006954 inflammatory response
GO:0032613 interleukin-10 production
GO:0042495 detection of triacyl bacterial lipopeptide
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0030177 positive regulation of Wnt signaling pathway
GO:0032735 positive regulation of interleukin-12 production
GO:0035325 Toll-like receptor binding
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0005886 plasma membrane
GO:0032760 positive regulation of tumor necrosis factor production
GO:0043312 neutrophil degranulation
GO:0005737 cytoplasm
GO:0007165 signal transduction
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0050135 NAD(P)+ nucleosidase activity
GO:0051964 negative regulation of synapse assembly
GO:0042834 peptidoglycan binding
GO:0032755 positive regulation of interleukin-6 production
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0071221 cellular response to bacterial lipopeptide
GO:1903974 positive regulation of cellular response to macrophage colony-stimulating factor stimulus
GO:0001775 cell activation
GO:0032733 positive regulation of interleukin-10 production
GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0071727 cellular response to triacyl bacterial lipopeptide
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:0007612 learning
GO:0009636 response to toxic substance
GO:0032289 central nervous system myelin formation
GO:1904466 positive regulation of matrix metallopeptidase secretion
GO:0032728 positive regulation of interferon-beta production
GO:0001540 amyloid-beta binding
GO:0006691 leukotriene metabolic process
GO:0032757 positive regulation of interleukin-8 production
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0050729 positive regulation of inflammatory response
GO:0071223 cellular response to lipoteichoic acid
GO:0008285 negative regulation of cell population proliferation
GO:0042497 triacyl lipopeptide binding

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Membrane
Membrane raft

Domains

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DomainNameCategoryType
IPR000157 Toll/interleukin-1 receptor homology (TIR) domainDomainDomain
IPR000483 Cysteine-rich flanking region, C-terminalDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR017241 Toll-like receptorFamilyFamily
IPR027185 Toll-like receptor 2FamilyFamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00045 Lyme disease vaccine (recombinant OspA)Drugbankbiotech
DB00210 AdapaleneDrugbanksmall molecule
DB03963 S-(Dimethylarsenic)CysteineDrugbanksmall molecule
DB05475 GolotimodDrugbanksmall molecule
DB11601 Tuberculin purified protein derivativeDrugbankbiotech

Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
TLR2_HUMANMYD88_HUMANBioGRID, HPRD, IntAct, MINT, UniProt15107846 16293622 16482509 17126326 29990310 details
TLR2_HUMANEGFR_HUMANBioGRID, IntAct, MINT17126326 24658140 25402006 31980649 details
TLR2_HUMANCXCR4_HUMANDIP, I2D18765807 20802527 details
TLR2_HUMANP85A_HUMANHPRD, MINT15007072 23247210 details
TLR2_HUMANA16L1_HUMANBioGRID, MINT23376921 27273576 29634390 details
TLR2_HUMANAKT1_HUMANBioGRID, MINT24412244 details
TLR2_HUMANAN32B_HUMANBioGRID, MINT24412244 details
TLR2_HUMANF16P1_HUMANBioGRID, MINT24412244 details
TLR2_HUMANHEMGN_HUMANBioGRID, MINT24412244 details
TLR2_HUMANMP2K1_HUMANBioGRID, MINT24412244 details
TLR2_HUMANSIAS_HUMANBioGRID, MINT24412244 details
TLR2_HUMANSMAD1_HUMANBioGRID, MINT24412244 details
TLR2_HUMANSTX17_HUMANBioGRID, MINT24412244 details
TLR2_HUMANTGFB1_HUMANBioGRID, MINT24412244 details
TLR2_HUMANTMOD1_HUMANBioGRID, MINT24412244 details
TLR2_HUMANPGS1_HUMANmatrixdb24480070 details
TLR2_HUMANTIRAP_HUMANBioGRID, IntAct17258210 18221795 details
TLR2_HUMANCD14_HUMANBioGRID, DIP, HPRD10395652 18765807 details
TLR2_HUMANSIGL5_HUMANIntAct25187624 details
TLR2_HUMANSIGL9_HUMANIntAct25187624 details
TLR2_HUMANTLR10_HUMANHPRD, IntAct15728506 23155421 details
TLR2_HUMANTLR2_HUMANBioGRID, IntAct10395652 23155421 details
TLR2_HUMANTLR1_HUMANBioGRID, HPRD, IntAct12077222 23155421 details
TLR2_HUMANTLR6_HUMANHPRD, IntAct, MINT12077222 20067962 23155421 details
TLR2_HUMANTOLIP_HUMANBioGRID, HPRD11751856 details
TLR2_HUMANTRI58_HUMANBioGRID31383741 details
TLR2_HUMANHMGB1_HUMANHPRD, MINT16267105 20067962 details
TLR2_HUMANLY96_HUMANBioGRID, HPRD11160242 details
TLR2_HUMANIRAK1_HUMANBioGRID, HPRD10395652 details
TLR2_HUMANCLC4M_HUMANBioGRID21899704 details
TLR2_HUMANCLC7A_HUMANBioGRID21899704 details
TLR2_HUMANCBP_HUMANBioGRID17126870 details
TLR2_HUMANIRF3_HUMANBioGRID17126870 details
TLR2_HUMANBCAP_HUMANBioGRID27909057 details
TLR2_HUMANRIPK2_HUMANBioGRID, HPRD11894098 32909611 details
TLR2_HUMANENPL_HUMANHPRD11912201 details
TLR2_HUMANSFTA1_HUMANHPRD11724772 details
TLR2_HUMANRASH_HUMANHPRD15496409 details
TLR2_HUMANRAC1_HUMANHPRD11101877 details
TLR2_HUMANTRIP6_HUMANHPRD15657077 details
TLR2_HUMANTCAM1_HUMANHPRD12471095 details
TLR2_HUMANJIP3_HUMANHPRD12941697 details