Entity Details

Primary name TM127_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75204
EntryNameTM127_HUMAN
FullNameTransmembrane protein 127
TaxID9606
Evidenceevidence at protein level
Length238
SequenceStatuscomplete
DateCreated2006-10-03
DateModified2021-06-02

Ontological Relatives

GenesTMEM127

GO terms

Show/Hide Table
GOName
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0007032 endosome organization
GO:0008285 negative regulation of cell population proliferation
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031267 small GTPase binding
GO:0032006 regulation of TOR signaling
GO:0032007 negative regulation of TOR signaling

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR033331 Transmembrane protein 127FamilyFamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
171300 OMIMPheochromocytoma (PCC)A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
TM127_HUMANWWP2_HUMANBioGRID32526160 details
TM127_HUMANDRA_HUMANBioGRID32526160 details