Entity Details

Primary name S1PR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95136
EntryNameS1PR2_HUMAN
FullNameSphingosine 1-phosphate receptor 2
TaxID9606
Evidenceevidence at protein level
Length353
SequenceStatuscomplete
DateCreated2003-11-07
DateModified2021-06-02

Ontological Relatives

GenesS1PR2

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001664 G protein-coupled receptor binding
GO:0003376 sphingosine-1-phosphate receptor signaling pathway
GO:0004930 G protein-coupled receptor activity
GO:0005178 integrin binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0008289 lipid binding
GO:0008528 G protein-coupled peptide receptor activity
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0014912 negative regulation of smooth muscle cell migration
GO:0016021 integral component of membrane
GO:0019222 regulation of metabolic process
GO:0031532 actin cytoskeleton reorganization
GO:0038036 sphingosine-1-phosphate receptor activity
GO:0046847 filopodium assembly
GO:0090394 negative regulation of excitatory postsynaptic potential
GO:1903142 positive regulation of establishment of endothelial barrier
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR004061 Sphingosine 1-phosphate receptorFamilyFamily
IPR004063 EDG-5 sphingosine 1-phosphate receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Disease IDSourceNameDescription
610419 OMIMDeafness, autosomal recessive, 68 (DFNB68)A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. The disease is caused by variants affecting the gene represented in this entry.