Entity Details

Primary name SIX6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95475
EntryNameSIX6_HUMAN
FullNameHomeobox protein SIX6
TaxID9606
Evidenceevidence at protein level
Length246
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesSIX6

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001654 eye development
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007601 visual perception
GO:0009887 animal organ morphogenesis
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR031701 Homeobox protein SIX1, N-terminal SD domainDomainDomain
IPR032947 Homeobox protein SIX6FamilyFamily

Diseases

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Disease IDSourceNameDescription
212550 OMIMOptic disk anomalies with retinal and/or macular dystrophy (ODRMD)An ocular disorder characterized by optic nerve dysplasia, optic disk anomalies, chorioretinal dystrophy and macular atrophy. Some patients have microphthalmia. The disease is caused by variants affecting the gene represented in this entry.

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
SIX6_HUMANTF2AY_HUMANBioGRID, IntAct20211142 details
SIX6_HUMANTLE1_HUMANBioGRID, HPRD12441302 details
SIX6_HUMANTLE5_HUMANBioGRID, HPRD12441302 details