Entity Details

Primary name RPA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95602
EntryNameRPA1_HUMAN
FullNameDNA-directed RNA polymerase I subunit RPA1
TaxID9606
Evidenceevidence at protein level
Length1720
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesPOLR1A

GO terms

Show/Hide Table
GOName
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005736 RNA polymerase I complex
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006363 termination of RNA polymerase I transcription
GO:0008270 zinc ion binding
GO:0045815 positive regulation of gene expression, epigenetic
GO:1904750 negative regulation of protein localization to nucleolus

Subcellular Location

Show/Hide Table
Subcellular Location
Chromosome
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000722 RNA polymerase, alpha subunitDomainDomain
IPR006592 RNA polymerase, N-terminalDomainDomain
IPR007066 RNA polymerase Rpb1, domain 3DomainDomain
IPR007080 RNA polymerase Rpb1, domain 1DomainDomain
IPR007081 RNA polymerase Rpb1, domain 5DomainDomain
IPR007083 RNA polymerase Rpb1, domain 4DomainDomain
IPR015699 DNA-directed RNA pol I, largest subunitFamilyFamily
IPR038120 RNA polymerase Rpb1, funnel domain superfamilyFamilyHomologous superfamily
IPR042102 RNA polymerase Rpb1, domain 3 superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
616462 OMIMAcrofacial dysostosis, Cincinnati type (AFDCIN)A form of acrofacial dysostosis, a group of disorders which are characterized by malformation of the craniofacial skeleton and, in some patients, the limbs. The disease is caused by variants affecting the gene represented in this entry.

Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
RPA1_HUMANRPA34_HUMANBioGRID, IntAct, MINT15226435 19214185 24981860 26496610 34079125 details
RPA1_HUMANRPA49_HUMANBioGRID, HPRD, IntAct, MINT15226435 19214185 24207024 24981860 26496610 34079125 details
RPA1_HUMANITF2_HUMANBioGRID, IntAct25416956 details
RPA1_HUMANREL_HUMANBioGRID, IntAct25416956 details
RPA1_HUMANDYDC2_HUMANBioGRID, IntAct32296183 details
RPA1_HUMANMEOX2_HUMANBioGRID32296183 details
RPA1_HUMANPTEN_HUMANBioGRID31685992 details
RPA1_HUMANIKBB_HUMANHPRD, IntAct14743216 details
RPA1_HUMANRPA2_HUMANBioGRID, IntAct, MINT16514417 19214185 22939629 24207024 24981860 26344197 26399832 26496610 details
RPA1_HUMANBARD1_HUMANUniProt10477523 details
RPA1_HUMANCSTF1_HUMANUniProt10477523 details
RPA1_HUMANRRN3_HUMANBioGRID, HPRD, MINT11250903 19214185 26496610 details
RPA1_HUMANERBB2_HUMANUniProt21555369 details
RPA1_HUMANNOLC1_HUMANBioGRID, HPRD10567578 26399832 details
RPA1_HUMANSIR7_HUMANBioGRID16618798 22147730 22586326 24207024 details
RPA1_HUMANERPG3_HUMANBioGRID20541997 23667505 details
RPA1_HUMANERCC6_HUMANBioGRID20541997 23667505 details
RPA1_HUMANUBF1_HUMANBioGRID22147730 22586326 28400511 details
RPA1_HUMANMBB1A_HUMANBioGRID22147730 22586326 details
RPA1_HUMANSMCA5_HUMANBioGRID22147730 22586326 details
RPA1_HUMANKAT2B_HUMANBioGRID23667505 details
RPA1_HUMANTCOF_HUMANBioGRID26399832 details
RPA1_HUMANNOP58_HUMANBioGRID26399832 details
RPA1_HUMANKBTB8_HUMANBioGRID26399832 details
RPA1_HUMANCSK21_HUMANBioGRID26399832 details
RPA1_HUMANRECQ5_HUMANBioGRID27502483 details
RPA1_HUMANBRCA1_HUMANBioGRID27589844 details
RPA1_HUMANSHPRH_HUMANBioGRID28400511 details
RPA1_HUMANAN32B_HUMANHPRD9285060 details