Entity Details

Primary name LGI1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95970
EntryNameLGI1_HUMAN
FullNameLeucine-rich glioma-inactivated protein 1
TaxID9606
Evidenceevidence at protein level
Length557
SequenceStatuscomplete
DateCreated2003-07-03
DateModified2021-06-02

Ontological Relatives

GenesLGI1

GO terms

Show/Hide Table
GOName
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0030307 positive regulation of cell growth
GO:0031175 neuron projection development
GO:0043083 synaptic cleft
GO:0050806 positive regulation of synaptic transmission
GO:0098978 glutamatergic synapse
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR000483 Cysteine-rich flanking region, C-terminalDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR005492 Leucine-rich glioma-inactivated , EPTP repeatRepeatRepeat
IPR009039 EARRepeatRepeat
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
600512 OMIMEpilepsy, familial temporal lobe, 1 (ETL1)A focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature. The disease is caused by variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
LGI1_HUMANDLG4_HUMANBioGRID16990550 details
LGI1_HUMANADA22_HUMANBioGRID, HPRD16990550 details