Entity Details

Primary name CHK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO96017
EntryNameCHK2_HUMAN
FullNameSerine/threonine-protein kinase Chk2
TaxID9606
Evidenceevidence at protein level
Length543
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesCHEK2

GO terms

Show/Hide Table
GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000086 G2/M transition of mitotic cell cycle
GO:0001934 positive regulation of protein phosphorylation
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0006302 double-strand break repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0006975 DNA damage induced protein phosphorylation
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016605 PML body
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0035690 cellular response to drug
GO:0042176 regulation of protein catabolic process
GO:0042770 signal transduction in response to DNA damage
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044257 cellular protein catabolic process
GO:0044773 mitotic DNA damage checkpoint signaling
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0050821 protein stabilization
GO:0051301 cell division
GO:0071480 cellular response to gamma radiation
GO:0090307 mitotic spindle assembly
GO:0090399 replicative senescence
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1903416 response to glycoside
GO:1903926 cellular response to bisphenol A
GO:2000002 negative regulation of DNA damage checkpoint
GO:2000210 positive regulation of anoikis

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000253 Forkhead-associated (FHA) domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
609265 OMIMLi-Fraumeni syndrome 2 (LFS2)A highly penetrant familial cancer syndrome that in its classic form is defined by the existence of a proband affected by a sarcoma before 45 years with a first degree relative affected by any tumor before 45 years and another first degree relative with any tumor before 45 years or a sarcoma at any age. Other clinical definitions for LFS have been proposed (PubMed:8118819 and PubMed:8718514) and called Li-Fraumeni like syndrome (LFL). In these families affected relatives develop a diverse set of malignancies at unusually early ages. Four types of cancers account for 80% of tumors occurring in TP53 germline mutation carriers: breast cancers, soft tissue and bone sarcomas, brain tumors (astrocytomas) and adrenocortical carcinomas. Less frequent tumors include choroid plexus carcinoma or papilloma before the age of 15, rhabdomyosarcoma before the age of 5, leukemia, Wilms tumor, malignant phyllodes tumor, colorectal and gastric cancers. The disease is caused by variants affecting the gene represented in this entry.
114480 OMIMBreast cancer (BC)A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. Disease susceptibility is associated with variants affecting the gene represented in this entry.
176807 OMIMProstate cancer (PC)A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Disease susceptibility is associated with variants affecting the gene represented in this entry.
259500 OMIMOsteogenic sarcoma (OSRC)A sarcoma originating in bone-forming cells, affecting the ends of long bones. The gene represented in this entry may be involved in disease pathogenesis.

Drugs

Show/Hide Table
DrugNameSourceType
DB05149 XL844Drugbanksmall molecule
DB06486 EnzastaurinDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

108 interactions

InteractorPartnerSourcesPublicationsLink
CHK2_HUMANMPIP1_HUMANBioGRID, HPRD, MINT10724175 11298456 12676583 12759351 18480045 details
CHK2_HUMANP53_HUMANBioGRID, HPRD, MINT10673501 10710310 10724175 12810724 12897801 15862297 17157788 18833288 details
CHK2_HUMANNBN_HUMANHPRD, MINT11438675 details
CHK2_HUMANMDM2_HUMANBioGRID, HPRD, MINT15862297 16943424 19176998 details
CHK2_HUMANIMA1_HUMANBioGRID, HPRD, IntAct, MINT12909615 23178491 details
CHK2_HUMANCHK2_HUMANBioGRID, MINT11438675 11901158 12024051 12676583 12909615 16794575 18239682 23178491 25361978 details
CHK2_HUMANAATF_HUMANBioGRID, HPRD, IntAct17157788 details
CHK2_HUMANPLK1_HUMANBioGRID, DIP, HPRD, IntAct10973490 11901158 12024051 12242661 12493754 20126263 details
CHK2_HUMANBRCA1_HUMANBioGRID, HPRD, IntAct10724175 12049740 12111733 12438214 17380128 17525332 18804494 26121674 details
CHK2_HUMANRB_HUMANBioGRID, MINT17380128 details
CHK2_HUMAN2A5E_HUMANBioGRID, HPRD, IntAct15380617 details
CHK2_HUMAN2A5A_HUMANBioGRID, HPRD, IntAct15380617 details
CHK2_HUMAN2A5B_HUMANBioGRID, HPRD, IntAct15380617 details
CHK2_HUMAN2A5G_HUMANBioGRID, HPRD, IntAct15380617 23178491 details
CHK2_HUMAN2A5D_HUMANBioGRID, HPRD, IntAct15380617 details
CHK2_HUMANSTRAP_HUMANBioGRID, MINT18833288 details
CHK2_HUMANXRCC1_HUMANMINT18971944 details
CHK2_HUMANRHG01_HUMANBioGRID, IntAct21988832 details
CHK2_HUMANRPAB5_HUMANBioGRID, IntAct21988832 details
CHK2_HUMANNR4A1_HUMANBioGRID, IntAct21988832 details
CHK2_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
CHK2_HUMANGNAS2_HUMANBioGRID, MINT25640309 details
CHK2_HUMANBAALC_HUMANBioGRID, MINT25640309 details
CHK2_HUMANENOA_HUMANBioGRID, MINT25640309 details
CHK2_HUMANSTMN1_HUMANBioGRID, MINT25640309 details
CHK2_HUMANHMGN1_HUMANBioGRID, MINT25640309 details
CHK2_HUMANADT3_HUMANBioGRID, MINT25640309 details
CHK2_HUMANANM2_HUMANBioGRID, MINT25640309 details
CHK2_HUMANTLR3_HUMANBioGRID, MINT25640309 details
CHK2_HUMANBEX1_HUMANBioGRID, MINT25640309 details
CHK2_HUMANCCL5_HUMANBioGRID, MINT25640309 details
CHK2_HUMANCAD13_HUMANBioGRID, MINT25640309 details
CHK2_HUMANCP17A_HUMANBioGRID, MINT25640309 details
CHK2_HUMANDIRA3_HUMANBioGRID, MINT25640309 details
CHK2_HUMANLRAT2_HUMANBioGRID, MINT25640309 details
CHK2_HUMANHXC6_HUMANBioGRID, MINT25640309 details
CHK2_HUMANIL24_HUMANBioGRID, MINT25640309 details
CHK2_HUMANITIH5_HUMANBioGRID, MINT25640309 details
CHK2_HUMANKLK9_HUMANBioGRID, MINT25640309 details
CHK2_HUMANKLK7_HUMANBioGRID, MINT25640309 details
CHK2_HUMANLYPD3_HUMANBioGRID, MINT25640309 details
CHK2_HUMANPRD14_HUMANBioGRID, MINT25640309 details
CHK2_HUMANHOP2_HUMANBioGRID, MINT25640309 details
CHK2_HUMANRHBT2_HUMANBioGRID, MINT25640309 details
CHK2_HUMANBRE1A_HUMANBioGRID, MINT25640309 details
CHK2_HUMANST14_HUMANBioGRID, MINT25640309 details
CHK2_HUMANNSD3_HUMANBioGRID, MINT25640309 details
CHK2_HUMANCD11A_HUMANIntAct23178491 details
CHK2_HUMANPP2AA_HUMANBioGRID, IntAct15380617 16596250 23178491 26083323 details
CHK2_HUMANRNF8_HUMANBioGRID, DIP22266820 details
CHK2_HUMANMSH2_HUMANBioGRID, HPRD12447371 15647386 details
CHK2_HUMANMDC1_HUMANBioGRID, HPRD12475977 12551934 12607004 details
CHK2_HUMANPLK3_HUMANBioGRID, HPRD10973490 11901158 12242661 12493754 12548019 details
CHK2_HUMANBRCA2_HUMANBioGRID14623252 17525332 18317453 details
CHK2_HUMANMUS81_HUMANBioGRID, HPRD11073977 11741546 details
CHK2_HUMANMDM4_HUMANBioGRID, HPRD16163388 details
CHK2_HUMANFOXM1_HUMANBioGRID17101782 details
CHK2_HUMANATR_HUMANBioGRID, HPRD10973490 11715017 12024051 12493754 17035231 9857181 details
CHK2_HUMANMPIP3_HUMANBioGRID, HPRD10557092 10744722 11053450 11333986 11438675 11551930 12024051 12402044 12897801 12909615 16311512 16705183 25361978 28094252 9278512 details
CHK2_HUMANREV3L_HUMANBioGRID18622427 details
CHK2_HUMANATM_HUMANBioGRID, HPRD10713094 10744722 10973490 11901158 12024051 12242661 12493754 15064416 15790808 16794575 20010693 details
CHK2_HUMAN2ABB_HUMANBioGRID, HPRD15380617 16596250 details
CHK2_HUMANELAV1_HUMANBioGRID17317627 19322201 details
CHK2_HUMANPSME3_HUMANBioGRID19556897 25361978 details
CHK2_HUMANLATS2_HUMANBioGRID21118956 details
CHK2_HUMANPML_HUMANBioGRID12402044 details
CHK2_HUMANDAPK3_HUMANBioGRID15001356 details
CHK2_HUMANA4_HUMANBioGRID21832049 details
CHK2_HUMANZN363_HUMANBioGRID23449389 details
CHK2_HUMANVHL_HUMANBioGRID22071692 details
CHK2_HUMANPRKDC_HUMANBioGRID10713094 17171639 details
CHK2_HUMANGNAS3_HUMANBioGRID25640309 details
CHK2_HUMANALEX_HUMANBioGRID25640309 details
CHK2_HUMANGNAS1_HUMANBioGRID25640309 details
CHK2_HUMANSRPK2_HUMANBioGRID26167880 details
CHK2_HUMANSIAH2_HUMANBioGRID26751770 details
CHK2_HUMANNFKB1_HUMANBioGRID21466675 details
CHK2_HUMANPPM1D_HUMANBioGRID16311512 28027003 details
CHK2_HUMANCDN1A_HUMANBioGRID12897801 details
CHK2_HUMANFHL1_HUMANBioGRID28094252 details
CHK2_HUMANFHL3_HUMANBioGRID28094252 details
CHK2_HUMANCD11B_HUMANBioGRID23178491 details
CHK2_HUMANTAU_HUMANBioGRID20159774 details
CHK2_HUMANSNUT2_HUMANBioGRID30771428 details
CHK2_HUMAN2ABA_HUMANHPRD15380617 details
CHK2_HUMANDBF4A_HUMANHPRD12441400 details
CHK2_HUMANMRC1_HUMANHPRD11715017 details
CHK2_HUMANTERA_HUMANBioGRID, IntAct17525332 29599191 details
CHK2_HUMANPSF2_HUMANBioGRID, IntAct17525332 details
CHK2_HUMANPER3_HUMANBioGRID, MINT21070773 details
CHK2_HUMAN2AAA_HUMANBioGRID, IntAct15380617 23178491 details
CHK2_HUMANTIF1B_HUMANBioGRID22496453 details
CHK2_HUMANKAT2B_HUMANBioGRID19176998 details
CHK2_HUMANUBR5_HUMANBioGRID17074762 details
CHK2_HUMANCUL4A_HUMANBioGRID23109433 details
CHK2_HUMANCUL1_HUMANBioGRID23109433 details
CHK2_HUMANSIR1_HUMANBioGRID25361978 details
CHK2_HUMANCCAR2_HUMANBioGRID25361978 details
CHK2_HUMANCNTN2_HUMANBioGRID15107832 details
CHK2_HUMANFHL2_HUMANBioGRID28094252 details
CHK2_HUMANRBTN1_HUMANBioGRID28094252 details
CHK2_HUMANRBTN2_HUMANBioGRID28094252 details
CHK2_HUMANLMO3_HUMANBioGRID28094252 details
CHK2_HUMANE2F1_HUMANHPRD12717439 details
CHK2_HUMANRAD9A_HUMANHPRD12049741 details
CHK2_HUMANTSSK1_HUMANHPRD12556502 details
CHK2_HUMANASF1A_HUMANHPRD11172707 details
CHK2_HUMANERCC6_HUMANHPRD9450932 details