Entity Details

Primary name LDHA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00338
EntryNameLDHA_HUMAN
FullNameL-lactate dehydrogenase A chain
TaxID9606
Evidenceevidence at protein level
Length332
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesLDHA

GO terms

Show/Hide Table
GOName
GO:0001666 response to hypoxia
GO:0004459 L-lactate dehydrogenase activity
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0006096 glycolytic process
GO:0007584 response to nutrient
GO:0009749 response to glucose
GO:0016020 membrane
GO:0019674 NAD metabolic process
GO:0019900 kinase binding
GO:0021762 substantia nigra development
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043627 response to estrogen
GO:0045296 cadherin binding
GO:0048569 post-embryonic animal organ development
GO:0051287 NAD binding
GO:0051591 response to cAMP
GO:0070062 extracellular exosome

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR001236 Lactate/malate dehydrogenase, N-terminalDomainDomain
IPR001557 L-lactate/malate dehydrogenaseFamilyFamily
IPR011304 L-lactate dehydrogenaseFamilyFamily
IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminalFamilyHomologous superfamily
IPR018177 L-lactate dehydrogenase, active siteSiteActive site
IPR022383 Lactate/malate dehydrogenase, C-terminalDomainDomain
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
612933 OMIMGlycogen storage disease 11 (GSD11)A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue. The disease is caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB02483 Etheno-NADDrugbanksmall molecule
DB02701 NicotinamideDrugbanksmall molecule
DB03940 Oxamic AcidDrugbanksmall molecule
DB09118 StiripentolDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule

Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
LDHA_HUMANXRN1_HUMANBioGRID, HPRD, IntAct15231747 details
LDHA_HUMANUB2E2_HUMANIntAct19549727 details
LDHA_HUMANLDHA_HUMANBioGRID, HPRD, IntAct11276087 21988832 25502805 31515488 details
LDHA_HUMANLDHB_HUMANBioGRID, IntAct21516116 21988832 22863883 22939629 25416956 25910212 28514442 31515488 32296183 details
LDHA_HUMANHSP7C_HUMANIntAct23523103 details
LDHA_HUMANAP2A_HUMANIntAct24835590 details
LDHA_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
LDHA_HUMANTINF2_HUMANbhf-ucl, BioGRID21044950 details
LDHA_HUMANACD_HUMANbhf-ucl, BioGRID21044950 details
LDHA_HUMANPOTE1_HUMANbhf-ucl, BioGRID21044950 details
LDHA_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
LDHA_HUMANPCNA_HUMANBioGRID, UniProt20849852 26030842 details
LDHA_HUMANMK10_HUMANBioGRID, IntAct25416956 31515488 32296183 details
LDHA_HUMANGSK3A_HUMANBioGRID, UniProt30824926 details
LDHA_HUMANPAXI1_HUMANBioGRID22990118 details
LDHA_HUMANRENT2_HUMANBioGRID15231747 details
LDHA_HUMAN1433T_HUMANBioGRID15161933 details
LDHA_HUMANPTPRF_HUMANBioGRID25458010 details
LDHA_HUMANFGFR1_HUMANBioGRID32572027 details
LDHA_HUMAN1433Z_HUMANMINT15161933 details
LDHA_HUMANHIF1A_HUMANBioGRID, IntAct21620138 25974097 details
LDHA_HUMANARNT_HUMANBioGRID, IntAct21620138 25974097 details
LDHA_HUMANKCJ11_HUMANBioGRID12145195 details
LDHA_HUMANABCC9_HUMANBioGRID, HPRD12145195 details
LDHA_HUMANKAT5_HUMANBioGRID20946988 details
LDHA_HUMANKAT2A_HUMANBioGRID20946988 details
LDHA_HUMANHDAC5_HUMANBioGRID21081666 details
LDHA_HUMANAKT1_HUMANBioGRID16027165 details
LDHA_HUMANHNF1A_HUMANBioGRID18160415 details
LDHA_HUMANHS90A_HUMANBioGRID16263121 details
LDHA_HUMANEFMT3_HUMANBioGRID23349634 details
LDHA_HUMANITA4_HUMANBioGRID22623428 details
LDHA_HUMANSQSTM_HUMANBioGRID26043024 32859246 details
LDHA_HUMANMTG16_HUMANBioGRID25974097 details
LDHA_HUMANCPT1A_HUMANBioGRID32859246 details
LDHA_HUMANATG5_HUMANBioGRID33024031 details
LDHA_HUMANHNRPD_HUMANHPRD12107167 details
LDHA_HUMANDYL1_HUMANHPRD14760703 details