Entity Details

Primary name FA9_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00740
EntryNameFA9_HUMAN
FullNameCoagulation factor IX
TaxID9606
Evidenceevidence at protein level
Length461
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesF9

GO terms

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GOName
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0031638 zymogen activation
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domainDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/ZFamilyFamily
IPR017857 Coagulation factor-like, Gla domain superfamilyFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR035694 Coagulation factor IXFamilyFamily
IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyFamilyHomologous superfamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
300807 OMIMThrombophilia, X-linked, due to factor IX defect (THPH8)A hemostatic disorder characterized by a tendency to thrombosis. The disease is caused by variants affecting the gene represented in this entry.
301052 OMIMWarfarin sensitivity, X-linked (WARFS)A condition characterized by sensitivity to warfarin, a drugs used as anti-coagulants for the prevention of thromboembolic diseases in subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement. Warfarin sensitive individuals develop bleeding complications when they are given warfarin within the therapeutic ranges. The disease is caused by variants affecting the gene represented in this entry.
306900 OMIMHemophilia B (HEMB)An X-linked blood coagulation disorder characterized by a permanent tendency to hemorrhage, due to factor IX deficiency. It is phenotypically similar to hemophilia A, but patients present with fewer symptoms. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00025 Antihemophilic factor, human recombinantDrugbankbiotech
DB00170 MenadioneDrugbanksmall molecule
DB05131 TTP889Drugbanksmall molecule
DB09109 Turoctocog alfaDrugbankbiotech
DB09332 KappadioneDrugbanksmall molecule
DB13150 Coagulation factor VII humanDrugbankbiotech
DB13151 Anti-inhibitor coagulant complexDrugbankbiotech
DB13192 Antihemophilic factor humanDrugbankbiotech
DB13923 EmicizumabDrugbankbiotech
DB13998 Lonoctocog alfaDrugbankbiotech
DB13999 Moroctocog alfaDrugbankbiotech
DB14738 Turoctocog alfa pegolDrugbankbiotech