Entity Details

Primary name RENI_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00797
EntryNameRENI_HUMAN
FullNameRenin
TaxID9606
Evidenceevidence at protein level
Length406
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesREN

GO terms

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GOName
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0002003 angiotensin maturation
GO:0002018 renin-angiotensin regulation of aldosterone production
GO:0004190 aspartic-type endopeptidase activity
GO:0005102 signaling receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0008217 regulation of blood pressure
GO:0008233 peptidase activity
GO:0008584 male gonad development
GO:0009755 hormone-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0035690 cellular response to drug
GO:0035902 response to immobilization stress
GO:0042756 drinking behavior
GO:0043408 regulation of MAPK cascade
GO:0045177 apical part of cell
GO:0048469 cell maturation
GO:0050435 amyloid-beta metabolic process
GO:0051591 response to cAMP
GO:0070305 response to cGMP

Subcellular Location

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Subcellular Location
Membrane
Secreted

Domains

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DomainNameCategoryType
IPR001461 Aspartic peptidase A1 familyFamilyFamily
IPR001969 Aspartic peptidase, active siteSiteActive site
IPR012848 Aspartic peptidase, N-terminalDomainDomain
IPR021109 Aspartic peptidase domain superfamilyFamilyHomologous superfamily
IPR033121 Peptidase family A1 domainDomainDomain
IPR034135 Renin-like domainDomainDomain

Diseases

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Disease IDSourceNameDescription
267430 OMIMRenal tubular dysgenesis (RTD)Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). The disease is caused by variants affecting the gene represented in this entry.
613092 OMIMFamilial juvenile hyperuricemic nephropathy 2 (HNFJ2)A renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00212 RemikirenDrugbanksmall molecule
DB00350 MinoxidilDrugbanksmall molecule
DB00722 LisinoprilDrugbanksmall molecule
DB01844 N,N-dimethylformamideDrugbanksmall molecule
DB02296 Isoamyl alcoholDrugbanksmall molecule
DB02803 3-Phenyl-1,2-PropandiolDrugbanksmall molecule
DB03024 2-Methyl-3-(2-Aminothiazolo)PropanalDrugbanksmall molecule
DB03395 EnalkirenDrugbanksmall molecule
DB03736 2-CyclopropylmethylenepropanalDrugbanksmall molecule
DB03968 1-Methyl-2-Oxy-5,5-Dimethyl PyrrolidineDrugbanksmall molecule
DB04379 N-Methyl-N-(Methylbenzyl)FormamideDrugbanksmall molecule
DB04387 1-Hydroxy-2-Amino-3-CyclohexylpropaneDrugbanksmall molecule
DB05203 SPP1148Drugbanksmall molecule
DB06899 N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL]ETHYL}ACETAMIDEDrugbanksmall molecule
DB06967 6-ETHYL-5-[9-(3-METHOXYPROPYL)-9H-CARBAZOL-2-YL]PYRIMIDINE-2,4-DIAMINEDrugbanksmall molecule
DB07059 N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL]ETHYL}ACETAMIDEDrugbanksmall molecule
DB07113 (2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONEDrugbanksmall molecule
DB07174 6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-4-(3-METHOXYPROPYL)-2,2-DIMETHYL-2H-1,4-BENZOXAZIN-3(4H)-ONEDrugbanksmall molecule
DB07244 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINEDrugbanksmall molecule
DB08099 6-ethyl-5-[(2S)-1-(3-methoxypropyl)-2-phenyl-1,2,3,4-tetrahydroquinolin-7-yl]pyrimidine-2,4-diamineDrugbanksmall molecule
DB09026 AliskirenDrugbanksmall molecule