Entity Details

Primary name COLI_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01189
EntryNameCOLI_HUMAN
FullNamePro-opiomelanocortin
TaxID9606
Evidenceevidence at protein level
Length267
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesPOMC

GO terms

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GOName
GO:0001664 G protein-coupled receptor binding
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0005102 signaling receptor binding
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005782 peroxisomal matrix
GO:0006091 generation of precursor metabolites and energy
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007267 cell-cell signaling
GO:0008217 regulation of blood pressure
GO:0019221 cytokine-mediated signaling pathway
GO:0030141 secretory granule
GO:0031640 killing of cells of other organism
GO:0031781 type 3 melanocortin receptor binding
GO:0031782 type 4 melanocortin receptor binding
GO:0032098 regulation of appetite
GO:0032720 negative regulation of tumor necrosis factor production
GO:0033059 cellular pigmentation
GO:0034774 secretory granule lumen
GO:0035821 modulation of process of other organism
GO:0042593 glucose homeostasis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0070873 regulation of glycogen metabolic process
GO:0070965 positive regulation of neutrophil mediated killing of fungus
GO:0070996 type 1 melanocortin receptor binding
GO:2000852 regulation of corticosterone secretion

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001941 Pro-opiomelanocortinFamilyFamily
IPR013531 Pro-opiomelanocortin/corticotropin, ACTH, central regionDomainDomain
IPR013532 Opiodes neuropeptideDomainDomain
IPR013593 Pro-opiomelanocortin N-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00836 LoperamideDrugbanksmall molecule
DB01497 EtorphineDrugbanksmall molecule
DB01565 DihydromorphineDrugbanksmall molecule

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
COLI_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
COLI_HUMANGLCTK_HUMANBioGRID, IntAct32296183 details
COLI_HUMANVA0D2_HUMANBioGRID, IntAct32296183 details
COLI_HUMANKLH42_HUMANBioGRID, IntAct32296183 details
COLI_HUMANNTAQ1_HUMANBioGRID, IntAct32296183 details
COLI_HUMANABI2_HUMANBioGRID, IntAct32296183 details
COLI_HUMANBHA09_HUMANBioGRID, IntAct32296183 details
COLI_HUMANIKBD_HUMANBioGRID, IntAct32296183 details
COLI_HUMANCA109_HUMANBioGRID, IntAct32296183 details
COLI_HUMANC102B_HUMANBioGRID, IntAct32296183 details
COLI_HUMANTHIOM_HUMANBioGRID, IntAct32296183 details
COLI_HUMANSUOX_HUMANBioGRID, IntAct32296183 details
COLI_HUMANERR3_HUMANBioGRID, IntAct32296183 details
COLI_HUMANMKRN3_HUMANBioGRID, IntAct32296183 details
COLI_HUMANHDDC2_HUMANBioGRID, IntAct32296183 details
COLI_HUMANOAZ3_HUMANBioGRID, IntAct32296183 details
COLI_HUMANVTNC_HUMANBioGRID, HPRD2475499 details
COLI_HUMANMC4R_HUMANBioGRID, HPRD11101306 12165561 9058374 details
COLI_HUMANMC5R_HUMANBioGRID, HPRD11606131 8185570 9058374 details
COLI_HUMANMC3R_HUMANBioGRID9058374 details
COLI_HUMANMSHR_HUMANBioGRID, HPRD10942578 11041375 9058374 details
COLI_HUMANA4_HUMANBioGRID21832049 details
COLI_HUMANDRB3_HUMANBioGRID, HPRD7477400 details
COLI_HUMANMEP1A_HUMANHPRD11278902 details
COLI_HUMANACTHR_HUMANHPRD12213892 details
COLI_HUMANNRDC_HUMANHPRD12590613 details
COLI_HUMANFGF10_HUMANHPRD12591959 details
COLI_HUMANAMD_HUMANHPRD18052119 details