Entity Details

Primary name IGF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01344
EntryNameIGF2_HUMAN
FullNameInsulin-like growth factor II
TaxID9606
Evidenceevidence at protein level
Length180
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesIGF2

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001892 embryonic placenta development
GO:0001934 positive regulation of protein phosphorylation
GO:0002576 platelet degranulation
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005178 integrin binding
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006006 glucose metabolic process
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organism development
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0009887 animal organ morphogenesis
GO:0031017 exocrine pancreas development
GO:0031056 regulation of histone modification
GO:0031093 platelet alpha granule lumen
GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0040018 positive regulation of multicellular organism growth
GO:0042104 positive regulation of activated T cell proliferation
GO:0043085 positive regulation of catalytic activity
GO:0043410 positive regulation of MAPK cascade
GO:0043539 protein serine/threonine kinase activator activity
GO:0044267 cellular protein metabolic process
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045840 positive regulation of mitotic nuclear division
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046622 positive regulation of organ growth
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0048018 receptor ligand activity
GO:0048633 positive regulation of skeletal muscle tissue growth
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051146 striated muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051148 negative regulation of muscle cell differentiation
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0060669 embryonic placenta morphogenesis
GO:0060720 spongiotrophoblast cell proliferation
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:2000467 positive regulation of glycogen (starch) synthase activity

Subcellular Location

Show/Hide Table
Subcellular Location
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR013576 Insulin-like growth factor II E-peptide, C-terminalDomainDomain
IPR016179 Insulin-likeDomainDomain
IPR022334 Insulin-like growth factor IIFamilyFamily
IPR022350 Insulin-like growth factorFamilyFamily
IPR022352 Insulin familyFamilyFamily
IPR022353 Insulin, conserved siteSiteConserved site
IPR036438 Insulin-like superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
616489 OMIMSilver-Russell syndrome 3 (SRS3)A form of Silver-Russell syndrome, a clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age. SRS3 inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.
180860 OMIMSilver-Russell syndrome 1 (SRS1)A form of Silver-Russell syndrome, a clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age. SRS1 is caused by epigenetic changes of DNA hypomethylation at the telomeric imprinting control region (ICR1) on chromosome 11p15, involving the H19 and IGF2 genes. The gene represented in this entry is involved in disease pathogenesis.

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
IGF2_HUMANMPRI_HUMANDIP, HPRD, MINT17850746 18046459 7797478 9722981 details
IGF2_HUMANCREL2_HUMANMINT21900206 details
IGF2_HUMANFAF1_HUMANBioGRID, MINT21900206 details
IGF2_HUMANNRK2_HUMANBioGRID, MINT21900206 details
IGF2_HUMANPGS2_HUMANmatrixdb24389353 details
IGF2_HUMANRBPMS_HUMANBioGRID, IntAct25416956 details
IGF2_HUMANGP152_HUMANBioGRID, IntAct32296183 details
IGF2_HUMANIBP1_HUMANBioGRID, DIP, HPRD, IntAct10810289 22578544 28514442 details
IGF2_HUMANIBP3_HUMANBioGRID, DIP, HPRD10407151 11600567 11749962 22578544 9446566 9497324 details
IGF2_HUMANIBP4_HUMANBioGRID, HPRD, IntAct31467278 9722589 details
IGF2_HUMANCCN3_HUMANBioGRID, HPRD10084601 details
IGF2_HUMANIBP7_HUMANBioGRID, HPRD8939990 details
IGF2_HUMANTRFE_HUMANBioGRID11749962 details
IGF2_HUMANVTNC_HUMANBioGRID, HPRD10342887 details
IGF2_HUMANIDE_HUMANBioGRID, HPRD1733942 details
IGF2_HUMANIBP6_HUMANBioGRID, HPRD7683646 details
IGF2_HUMANIBP5_HUMANBioGRID, HPRD9497324 details
IGF2_HUMANBAG6_HUMANBioGRID21900206 details
IGF2_HUMANPCSK4_HUMANBioGRID, HPRD16040806 details
IGF2_HUMANCLN5_HUMANBioGRID32296183 details
IGF2_HUMANTRI55_HUMANBioGRID31391242 details
IGF2_HUMANTRI63_HUMANBioGRID31391242 details
IGF2_HUMANPLMN_HUMANHPRD15642732 details
IGF2_HUMANCCN5_HUMANHPRD10358067 details
IGF2_HUMANIBP2_HUMANHPRD1714916 2465304 8781553 details
IGF2_HUMANIGF1R_HUMANHPRD9972281 details
IGF2_HUMANINSR_HUMANHPRD9722981 details
IGF2_HUMANGPC3_HUMANHPRD8589713 details