Entity Details

Primary name IGKC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01834
EntryNameIGKC_HUMAN
FullNameImmunoglobulin kappa constant
TaxID9606
Evidenceevidence at protein level
Length107
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0001895 retina homeostasis
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003823 antigen binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0006898 receptor-mediated endocytosis
GO:0006910 phagocytosis, recognition
GO:0006911 phagocytosis, engulfment
GO:0006955 immune response
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0008228 opsonization
GO:0009897 external side of plasma membrane
GO:0018149 peptide cross-linking
GO:0030449 regulation of complement activation
GO:0034987 immunoglobulin receptor binding
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042571 immunoglobulin complex, circulating
GO:0042742 defense response to bacterium
GO:0045087 innate immune response
GO:0050776 regulation of immune response
GO:0050853 B cell receptor signaling pathway
GO:0050871 positive regulation of B cell activation
GO:0050900 leukocyte migration
GO:0070062 extracellular exosome
GO:0072562 blood microparticle

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614102 OMIMImmunoglobulin kappa light chain deficiency (IGKCD)A disease characterized by the complete absence of immunoglobulin kappa chains. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01851 Tetrabutylammonium IonDrugbanksmall molecule
DB04688 MethylecgonineDrugbanksmall molecule
DB07375 EtiocholanedioneDrugbanksmall molecule
DB07416 (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATEDrugbanksmall molecule
DB07441 3-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACIDDrugbanksmall molecule
DB07716 (4Z)-2,8:7,12:11,15:14,18:17,22-PENTAANHYDRO-4,5,6,9,10,13,19,20,21-NONADEOXY-D-ARABINO-D-ALLO-D-ALLO-DOCOSA-4,9,20-TRIENITOLDrugbanksmall molecule
DB07784 [4-(4-ACETYLAMINO-PHENYL)-3,5-DIOXO-4-AZA-TRICYCLO[5.2.2.0 2,6]UNDEC-1-YLCARBAMOYLOXY]-ACETIC ACIDDrugbanksmall molecule
DB07882 4-{4-[2-(1A,7A-DIMETHYL-4-OXY-OCTAHYDRO-1-OXA-4-AZA-CYCLOPROPA[A]NAPHTHALEN-4-YL) -ACETYLAMINO]-PHENYLCARBAMOYL}-BUTYRIC ACIDDrugbanksmall molecule
DB07893 PHENYL[1-(N-SUCCINYLAMINO)PENTYL]PHOSPHONATEDrugbanksmall molecule
DB07909 (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOLDrugbanksmall molecule
DB08289 N-(PARA-GLUTARAMIDOPHENYL-ETHYL)-PIPERIDINIUM-N-OXIDEDrugbanksmall molecule
DB08413 METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTERDrugbanksmall molecule
DB08562 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACIDDrugbanksmall molecule
DB08647 TRAZEOLIDEDrugbanksmall molecule