Entity Details

Primary name APOC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02655
EntryNameAPOC2_HUMAN
FullNameApolipoprotein C-II
TaxID9606
Evidenceevidence at protein level
Length101
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesAPOC2

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005769 early endosome
GO:0008289 lipid binding
GO:0010518 positive regulation of phospholipase activity
GO:0010898 positive regulation of triglyceride catabolic process
GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling
GO:0010916 negative regulation of very-low-density lipoprotein particle clearance
GO:0016004 phospholipase activator activity
GO:0016042 lipid catabolic process
GO:0030522 intracellular receptor signaling pathway
GO:0032375 negative regulation of cholesterol transport
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034361 very-low-density lipoprotein particle
GO:0034362 low-density lipoprotein particle
GO:0034363 intermediate-density lipoprotein particle
GO:0034366 spherical high-density lipoprotein particle
GO:0034370 triglyceride-rich lipoprotein particle remodeling
GO:0034371 chylomicron remodeling
GO:0034372 very-low-density lipoprotein particle remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034378 chylomicron assembly
GO:0034382 chylomicron remnant clearance
GO:0034384 high-density lipoprotein particle clearance
GO:0042627 chylomicron
GO:0042632 cholesterol homeostasis
GO:0042802 identical protein binding
GO:0043274 phospholipase binding
GO:0043691 reverse cholesterol transport
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0045833 negative regulation of lipid metabolic process
GO:0048261 negative regulation of receptor-mediated endocytosis
GO:0051006 positive regulation of lipoprotein lipase activity
GO:0055102 lipase inhibitor activity
GO:0060230 lipoprotein lipase activator activity
GO:0060697 positive regulation of phospholipid catabolic process
GO:0070328 triglyceride homeostasis

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR008019 Apolipoprotein C-IIFamilyFamily
IPR023121 ApoC-II domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
207750 OMIMHyperlipoproteinemia 1B (HLPP1B)Autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB09130 CopperDrugbanksmall molecule