Entity Details

Primary name APOC3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02656
EntryNameAPOC3_HUMAN
FullNameApolipoprotein C-III
TaxID9606
Evidenceevidence at protein level
Length99
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesAPOC3

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005769 early endosome
GO:0006641 triglyceride metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0010897 negative regulation of triglyceride catabolic process
GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling
GO:0010916 negative regulation of very-low-density lipoprotein particle clearance
GO:0010987 negative regulation of high-density lipoprotein particle clearance
GO:0010989 negative regulation of low-density lipoprotein particle clearance
GO:0015485 cholesterol binding
GO:0019433 triglyceride catabolic process
GO:0030234 enzyme regulator activity
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034361 very-low-density lipoprotein particle
GO:0034363 intermediate-density lipoprotein particle
GO:0034366 spherical high-density lipoprotein particle
GO:0034371 chylomicron remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034378 chylomicron assembly
GO:0034379 very-low-density lipoprotein particle assembly
GO:0034382 chylomicron remnant clearance
GO:0042157 lipoprotein metabolic process
GO:0042627 chylomicron
GO:0042632 cholesterol homeostasis
GO:0043691 reverse cholesterol transport
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0045833 negative regulation of lipid metabolic process
GO:0048261 negative regulation of receptor-mediated endocytosis
GO:0050995 negative regulation of lipid catabolic process
GO:0051005 negative regulation of lipoprotein lipase activity
GO:0055102 lipase inhibitor activity
GO:0060621 negative regulation of cholesterol import
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070328 triglyceride homeostasis
GO:0070653 high-density lipoprotein particle receptor binding

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR008403 Apolipoprotein CIIIFamilyFamily
IPR038195 Apolipoprotein CIII superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614028 OMIMHyperalphalipoproteinemia 2 (HALP2)A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB09130 CopperDrugbanksmall molecule
DB15067 VolanesorsenDrugbankbiotech