Entity Details

Primary name FIBB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02675
EntryNameFIBB_HUMAN
FullNameFibrinogen beta chain
TaxID9606
Evidenceevidence at protein level
Length491
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesFGB

GO terms

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GOName
GO:0002224 toll-like receptor signaling pathway
GO:0002250 adaptive immune response
GO:0002576 platelet degranulation
GO:0005102 signaling receptor binding
GO:0005198 structural molecule activity
GO:0005201 extracellular matrix structural constituent
GO:0005576 extracellular region
GO:0005577 fibrinogen complex
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007596 blood coagulation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0030198 extracellular matrix organization
GO:0031091 platelet alpha granule
GO:0031093 platelet alpha granule lumen
GO:0031639 plasminogen activation
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0034622 cellular protein-containing complex assembly
GO:0042730 fibrinolysis
GO:0043152 induction of bacterial agglutination
GO:0044320 cellular response to leptin stimulus
GO:0045087 innate immune response
GO:0045202 synapse
GO:0045907 positive regulation of vasoconstriction
GO:0045921 positive regulation of exocytosis
GO:0050714 positive regulation of protein secretion
GO:0051087 chaperone binding
GO:0051258 protein polymerization
GO:0051592 response to calcium ion
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0071347 cellular response to interleukin-1
GO:0072378 blood coagulation, fibrin clot formation
GO:0072562 blood microparticle
GO:0090277 positive regulation of peptide hormone secretion
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903561 extracellular vesicle
GO:2000352 negative regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domainDomainDomain
IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domainDomainDomain
IPR020837 Fibrinogen, conserved siteSiteConserved site
IPR036056 Fibrinogen-like, C-terminalFamilyHomologous superfamily
IPR037580 Fibrinogen beta chainFamilyFamily

Diseases

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Disease IDSourceNameDescription
202400 OMIMCongenital afibrinogenemia (CAFBN)Rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. The disease is caused by variants affecting the gene represented in this entry. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.
616004 OMIMDysfibrinogenemia, congenital (DYSFIBRIN)A disorder characterized by qualitative abnormalities (dysfibrinogenemia) of the circulating fibrinogen. Affected individuals are frequently asymptomatic, but some patients have bleeding diathesis, thromboembolic complications, or both. In some cases, dysfibrinogenemia is associated with low circulating fibrinogen levels (hypodysfibrinogenemia). The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00364 SucralfateDrugbanksmall molecule
DB04919 AlfimepraseDrugbankbiotech
DB11300 ThrombinDrugbankbiotech
DB11311 ProthrombinDrugbankbiotech
DB11571 Human thrombinDrugbankbiotech
DB11572 Thrombin alfaDrugbankbiotech
DB13151 Anti-inhibitor coagulant complexDrugbankbiotech