Entity Details

Primary name C1QC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02747
EntryNameC1QC_HUMAN
FullNameComplement C1q subcomponent subunit C
TaxID9606
Evidenceevidence at protein level
Length245
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesC1QC

GO terms

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GOName
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0005615 extracellular space
GO:0006955 immune response
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0030449 regulation of complement activation
GO:0030853 negative regulation of granulocyte differentiation
GO:0045087 innate immune response
GO:0045202 synapse
GO:0045650 negative regulation of macrophage differentiation
GO:0062023 collagen-containing extracellular matrix
GO:0072562 blood microparticle
GO:0098794 postsynapse
GO:0098883 synapse pruning

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001073 C1q domainDomainDomain
IPR008160 Collagen triple helix repeatRepeatRepeat
IPR008983 Tumour necrosis factor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613652 OMIMComplement component C1q deficiency (C1QD)A disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00002 CetuximabDrugbankbiotech
DB00005 EtanerceptDrugbankbiotech
DB00110 PalivizumabDrugbankbiotech
DB00111 DaclizumabDrugbankbiotech
DB00112 BevacizumabDrugbankbiotech
DB01593 ZincDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule