Entity Details

Primary name TFR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02786
EntryNameTFR1_HUMAN
FullNameTransferrin receptor protein 1
TaxID9606
Evidenceevidence at protein level
Length760
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesTFRC

GO terms

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GOName
GO:0001618 virus receptor activity
GO:0001934 positive regulation of protein phosphorylation
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004998 transferrin receptor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005768 endosome
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005905 clathrin-coated pit
GO:0006826 iron ion transport
GO:0006879 cellular iron ion homeostasis
GO:0008235 metalloexopeptidase activity
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010628 positive regulation of gene expression
GO:0010637 negative regulation of mitochondrial fusion
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0019901 protein kinase binding
GO:0030316 osteoclast differentiation
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0030890 positive regulation of B cell proliferation
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031410 cytoplasmic vesicle
GO:0031623 receptor internalization
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033572 transferrin transport
GO:0035556 intracellular signal transduction
GO:0035690 cellular response to drug
GO:0042102 positive regulation of T cell proliferation
GO:0042470 melanosome
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 intracellular membrane-bounded organelle
GO:0044877 protein-containing complex binding
GO:0045780 positive regulation of bone resorption
GO:0045830 positive regulation of isotype switching
GO:0048471 perinuclear region of cytoplasm
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0055037 recycling endosome
GO:0061024 membrane organization
GO:0070062 extracellular exosome
GO:0072562 blood microparticle
GO:0150104 transport across blood-brain barrier
GO:1900182 positive regulation of protein localization to nucleus
GO:1903561 extracellular vesicle
GO:1990712 HFE-transferrin receptor complex
GO:1990830 cellular response to leukemia inhibitory factor

Subcellular Location

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Subcellular Location
Cell membrane
Melanosome
Secreted

Domains

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DomainNameCategoryType
IPR003137 PA domainDomainDomain
IPR007365 Transferrin receptor-like, dimerisation domainDomainDomain
IPR007484 Peptidase M28DomainDomain
IPR029513 Transferrin receptor protein 1FamilyFamily
IPR036757 Transferrin receptor-like, dimerisation domain superfamilyFamilyHomologous superfamily
IPR037324 Transferrin receptor protein 1/2, PA domainDomainDomain
IPR039373 Glutamate carboxypeptidase 2-likeFamilyFamily

Diseases

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Disease IDSourceNameDescription
616740 OMIMImmunodeficiency 46 (IMD46)An autosomal recessive primary immunodeficiency disorder characterized by early-onset chronic diarrhea, recurrent infections, hypo- or agammaglobulinemia, normal lymphocyte counts, intermittent neutropenia, and intermittent thrombocytopenia. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01592 IronDrugbanksmall molecule
DB05260 Gallium nitrateDrugbanksmall molecule
DB06784 Gallium citrate Ga-67Swissprotsmall molecule
DB13257 Ferrous sulfate anhydrousDrugbanksmall molecule
DB13949 Ferric cationDrugbanksmall molecule
DB14488 Ferrous gluconateDrugbanksmall molecule
DB14489 Ferrous succinateDrugbanksmall molecule
DB14490 Ferrous ascorbateDrugbanksmall molecule
DB14491 Ferrous fumarateDrugbanksmall molecule
DB14501 Ferrous glycine sulfateDrugbanksmall molecule
DB14520 Tetraferric tricitrate decahydrateDrugbanksmall molecule
DB15617 Ferric derisomaltoseDrugbanksmall molecule

Interactions

77 interactions

InteractorPartnerSourcesPublicationsLink
TFR1_HUMANTRFE_HUMANBioGRID, DIP, HPRD, IntAct11027676 12210842 14691533 16271884 16354665 20404192 21788477 29302006 6268632 details
TFR1_HUMANSH3B4_HUMANBioGRID, MINT16325581 details
TFR1_HUMANHFE_HUMANBioGRID, DIP, HPRD, MINT, UniProt11027676 14691533 15965644 20133674 20618438 9465039 details
TFR1_HUMANALBU_HUMANMINT23384347 details
TFR1_HUMANTFR1_HUMANBioGRID, DIP, HPRD, MINT10531064 10638746 14980223 20208545 23384347 29302006 details
TFR1_HUMANRAB8A_HUMANBioGRID, UniProt20085643 22854040 details
TFR1_HUMANSGTA_HUMANBioGRID, IntAct25416956 32296183 details
TFR1_HUMANPAGE1_HUMANBioGRID, IntAct32296183 details
TFR1_HUMANMGST3_HUMANBioGRID, IntAct32296183 details
TFR1_HUMANLHPL5_HUMANBioGRID, IntAct32296183 details
TFR1_HUMANF210B_HUMANBioGRID, IntAct32296183 details
TFR1_HUMANVMAT1_HUMANBioGRID, IntAct32296183 details
TFR1_HUMANGET1_HUMANBioGRID, IntAct32296183 details
TFR1_HUMANGP152_HUMANBioGRID, IntAct32296183 details
TFR1_HUMANF209A_HUMANBioGRID, IntAct32296183 details
TFR1_HUMANRELL2_HUMANBioGRID, IntAct32296183 details
TFR1_HUMAN3HIDH_HUMANBioGRID, IntAct32296183 details
TFR1_HUMANRMD3_HUMANBioGRID, IntAct32296183 details
TFR1_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
TFR1_HUMANMFF_HUMANBioGRID, IntAct32296183 details
TFR1_HUMANASGR2_HUMANBioGRID, IntAct32296183 details
TFR1_HUMANCR3L1_HUMANBioGRID, IntAct32296183 details
TFR1_HUMANNTCP_HUMANBioGRID, IntAct32296183 details
TFR1_HUMANCA159_HUMANBioGRID, IntAct32296183 details
TFR1_HUMANRASF3_HUMANBioGRID, IntAct32296183 details
TFR1_HUMANAR13B_HUMANBioGRID, IntAct32296183 details
TFR1_HUMANFRIH_HUMANDIP20133674 details
TFR1_HUMANGBRAP_HUMANBioGRID, HPRD11997026 details
TFR1_HUMANB4GT1_HUMANBioGRID7744867 details
TFR1_HUMANLMNA_HUMANBioGRID24623722 details
TFR1_HUMANIKKE_HUMANIntAct14743216 details
TFR1_HUMANRANB9_HUMANBioGRID, HPRD, MINT14722085 details
TFR1_HUMANTRAF6_HUMANIntAct17353931 details
TFR1_HUMANCRCM_HUMANIntAct17353931 details
TFR1_HUMANHLAB_HUMANIntAct17353931 details
TFR1_HUMAN1433Z_HUMANMINT15161933 details
TFR1_HUMANMYO1G_HUMANBioGRID, MINT19968988 details
TFR1_HUMANSPP2A_HUMANMINT23384347 details
TFR1_HUMANSPP2B_HUMANMINT23384347 details
TFR1_HUMANTBC14_HUMANbhf-ucl22613832 details
TFR1_HUMANATG9A_HUMANbhf-ucl, BioGRID22456507 22613832 details
TFR1_HUMANEPS15_HUMANIntAct23211419 details
TFR1_HUMANTBC17_HUMANUniProt22854040 details
TFR1_HUMANZNT10_HUMANBioGRID, UniProt26728129 details
TFR1_HUMANTGON2_HUMANBioGRID, IntAct27791468 29568061 details
TFR1_HUMANSVIP_HUMANBioGRID17872946 details
TFR1_HUMANPXK_HUMANBioGRID20086096 details
TFR1_HUMANBST2_HUMANBioGRID20980512 details
TFR1_HUMANHDAC5_HUMANBioGRID21081666 details
TFR1_HUMANLAP4A_HUMANBioGRID22096579 details
TFR1_HUMANLAP4B_HUMANBioGRID22096579 details
TFR1_HUMANOPTN_HUMANBioGRID20085643 20161783 20634958 23357852 details
TFR1_HUMANHGS_HUMANBioGRID11988743 details
TFR1_HUMANPRKN_HUMANBioGRID18362144 details
TFR1_HUMANKCNA3_HUMANBioGRID18218624 details
TFR1_HUMANKCNA5_HUMANBioGRID18218624 details
TFR1_HUMANFBX6_HUMANBioGRID22268729 32409323 details
TFR1_HUMANVATB1_HUMANBioGRID21674799 details
TFR1_HUMANMARH1_HUMANBioGRID23606747 details
TFR1_HUMANMARH8_HUMANBioGRID23606747 32614325 details
TFR1_HUMANCAV1_HUMANBioGRID14627714 34079125 details
TFR1_HUMANARFG1_HUMANBioGRID21499258 details
TFR1_HUMANAP2B1_HUMANBioGRID21499258 34079125 details
TFR1_HUMANFBX27_HUMANBioGRID28743755 details
TFR1_HUMANA16L1_HUMANBioGRID27875067 details
TFR1_HUMANSTX6_HUMANBioGRID27791468 34079125 details
TFR1_HUMANMLP3B_HUMANBioGRID27791468 details
TFR1_HUMANRAB17_HUMANBioGRID27791468 details
TFR1_HUMANIKKA_HUMANBioGRID23016877 details
TFR1_HUMANIKKB_HUMANBioGRID23016877 details
TFR1_HUMANNEMO_HUMANBioGRID23016877 details
TFR1_HUMANACE2_HUMANBioGRID888800000133 details
TFR1_HUMANISG15_HUMANBioGRID33024031 details
TFR1_HUMANRAB5B_HUMANHPRD7789520 details
TFR1_HUMANCD3Z_HUMANHPRD9448136 details
TFR1_HUMANACAP1_HUMANHPRD15525538 details
TFR1_HUMANCD4_HUMANHPRD14705953 details