Entity Details

Primary name TRFL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02788
EntryNameTRFL_HUMAN
FullNameLactotransferrin
TaxID9606
Evidenceevidence at protein level
Length710
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesLTF

GO terms

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GOName
GO:0001503 ossification
GO:0001530 lipopolysaccharide binding
GO:0001817 regulation of cytokine production
GO:0001895 retina homeostasis
GO:0002227 innate immune response in mucosa
GO:0003677 DNA binding
GO:0004252 serine-type endopeptidase activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005506 iron ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0006826 iron ion transport
GO:0006959 humoral immune response
GO:0008201 heparin binding
GO:0009986 cell surface
GO:0019730 antimicrobial humoral response
GO:0019731 antibacterial humoral response
GO:0019732 antifungal humoral response
GO:0030141 secretory granule
GO:0031640 killing of cells of other organism
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032680 regulation of tumor necrosis factor production
GO:0032780 negative regulation of ATPase activity
GO:0032991 protein-containing complex
GO:0033214 siderophore-dependent iron import into cell
GO:0033690 positive regulation of osteoblast proliferation
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0035580 specific granule lumen
GO:0042581 specific granule
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043312 neutrophil degranulation
GO:0043539 protein serine/threonine kinase activator activity
GO:0044793 negative regulation by host of viral process
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0045669 positive regulation of osteoblast differentiation
GO:0045837 negative regulation of membrane potential
GO:0048525 negative regulation of viral process
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051673 membrane disruption in other organism
GO:0055037 recycling endosome
GO:0060349 bone morphogenesis
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0070062 extracellular exosome
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0097013 phagocytic vesicle lumen
GO:1900159 positive regulation of bone mineralization involved in bone maturation
GO:1900229 negative regulation of single-species biofilm formation in or on host organism
GO:1902732 positive regulation of chondrocyte proliferation
GO:1904724 tertiary granule lumen
GO:1990000 amyloid fibril formation
GO:2000117 negative regulation of cysteine-type endopeptidase activity
GO:2000308 negative regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:2001205 negative regulation of osteoclast development

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic granule
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR001156 Transferrin-like domainDomainDomain
IPR016357 TransferrinFamilyFamily
IPR018195 Transferrin family, iron binding siteSiteBinding site
IPR030684 LactotransferrinFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB01811 3h-Indole-5,6-DiolDrugbanksmall molecule
DB03017 Lauric acidDrugbanksmall molecule
DB03040 Nitrilotriacetic acidDrugbanksmall molecule
DB03485 alpha-D-FucopyranoseDrugbanksmall molecule
DB04743 NimesulideDrugbanksmall molecule
DB06987 (R)-AtenololDrugbanksmall molecule
DB08439 ParecoxibDrugbanksmall molecule
DB11182 Rose bengalSwissprotsmall molecule