Entity Details

Primary name MYCN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04198
EntryNameMYCN_HUMAN
FullNameN-myc proto-oncogene protein
TaxID9606
Evidenceevidence at protein level
Length464
SequenceStatuscomplete
DateCreated1987-03-20
DateModified2021-06-02

Ontological Relatives

GenesMYCN

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0019900 kinase binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR002418 Transcription regulator MycFamilyFamily
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR012682 Transcription regulator Myc, N-terminalDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
164280 OMIMFeingold syndrome 1 (FGLDS1)A syndrome characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability, mental retardation, and limb malformations. Hand and foot abnormalities may include hypoplastic thumbs, clinodactyly of second and fifth fingers, syndactyly (characteristically between second and third and fourth and fifth toes), and shortened or absent middle phalanges. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described. The disease is caused by variants affecting the gene represented in this entry.

Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
MYCN_HUMANMAX_HUMANBioGRID, DIP, HPRD, IntAct10229200 10597290 17289033 18003922 18488021 1935896 2006410 20946988 23792191 24859015 25175806 26062444 27728805 29028833 details
MYCN_HUMANNMI_HUMANBioGRID, HPRD, IntAct10597290 8668343 details
MYCN_HUMANAURKA_HUMANBioGRID, IntAct19111882 19997598 23792191 25175806 27728805 27837025 details
MYCN_HUMANFBXW7_HUMANBioGRID, IntAct19111882 27837025 details
MYCN_HUMANSP1_HUMANBioGRID, DIP, I2D18003922 20697349 21123453 details
MYCN_HUMANSIR1_HUMANBioGRID, UniProt21698133 details
MYCN_HUMANZBT17_HUMANBioGRID, IntAct21123453 21908575 26766587 details
MYCN_HUMANEZH2_HUMANBioGRID, IntAct23362253 27728805 details
MYCN_HUMANCSK21_HUMANBioGRID, HPRD1425701 details
MYCN_HUMANYETS4_HUMANBioGRID22068108 details
MYCN_HUMANTRI32_HUMANBioGRID25100564 details
MYCN_HUMANNEDD4_HUMANBioGRID23175188 details
MYCN_HUMANWDR5_HUMANBioGRID26471359 details
MYCN_HUMANHUWE1_HUMANBioGRID18488021 details
MYCN_HUMANANM1_HUMANBioGRID27571165 details
MYCN_HUMANRUNX3_HUMANBioGRID23851507 details
MYCN_HUMANDOT1L_HUMANBioGRID28209620 details
MYCN_HUMANYAF2_HUMANHPRD11593398 details
MYCN_HUMANGSK3B_HUMANIntAct17353931 details
MYCN_HUMANARF_HUMANBioGRID, MINT17289033 details
MYCN_HUMANCDN2A_HUMANBioGRID17289033 details
MYCN_HUMANHDAC5_HUMANBioGRID23812427 details
MYCN_HUMANTRRAP_HUMANBioGRID17704800 details
MYCN_HUMANSKP2_HUMANBioGRID17704800 details
MYCN_HUMANUBC_HUMANBioGRID23851507 details
MYCN_HUMANHDAC9_HUMANBioGRID24952595 details
MYCN_HUMANDNMT1_HUMANBioGRID23280764 details
MYCN_HUMANDNM3A_HUMANBioGRID23280764 details
MYCN_HUMANRB_HUMANBioGRID23280764 details
MYCN_HUMANKDM1A_HUMANBioGRID26062444 details
MYCN_HUMANCDN1A_HUMANBioGRID26062444 details
MYCN_HUMANCLUS_HUMANBioGRID26062444 details
MYCN_HUMANGLSL_HUMANBioGRID26528759 details
MYCN_HUMANNUCL_HUMANBioGRID26528759 details
MYCN_HUMANINSM1_HUMANBioGRID26456864 details
MYCN_HUMANKDM5B_HUMANBioGRID24481781 details
MYCN_HUMANDCOR_HUMANBioGRID28209620 details
MYCN_HUMANE2F2_HUMANBioGRID28209620 details
MYCN_HUMANUBP11_HUMANBioGRID30894746 details
MYCN_HUMANBRCA1_HUMANBioGRID30894746 details
MYCN_HUMANUBP7_HUMANBioGRID30894746 details
MYCN_HUMANBMI1_HUMANBioGRID31856871 details
MYCN_HUMANRING1_HUMANBioGRID31856871 details
MYCN_HUMANRING2_HUMANBioGRID31856871 details
MYCN_HUMANCSK22_HUMANHPRD1425701 details
MYCN_HUMANMAD1_HUMANHPRD11602341 details