Entity Details

Primary name AT1A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05023
EntryNameAT1A1_HUMAN
FullNameSodium/potassium-transporting ATPase subunit alpha-1
TaxID9606
Evidenceevidence at protein level
Length1023
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesATP1A1

GO terms

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GOName
GO:0002026 regulation of the force of heart contraction
GO:0002028 regulation of sodium ion transport
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005524 ATP binding
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0005901 caveola
GO:0006883 cellular sodium ion homeostasis
GO:0008217 regulation of blood pressure
GO:0014069 postsynaptic density
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0016791 phosphatase activity
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0030007 cellular potassium ion homeostasis
GO:0030315 T-tubule
GO:0030506 ankyrin binding
GO:0030955 potassium ion binding
GO:0031090 organelle membrane
GO:0031402 sodium ion binding
GO:0031947 negative regulation of glucocorticoid biosynthetic process
GO:0032991 protein-containing complex
GO:0034220 ion transmembrane transport
GO:0036126 sperm flagellum
GO:0036376 sodium ion export across plasma membrane
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0042493 response to drug
GO:0043531 ADP binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0045121 membrane raft
GO:0045822 negative regulation of heart contraction
GO:0045823 positive regulation of heart contraction
GO:0045989 positive regulation of striated muscle contraction
GO:0046982 protein heterodimerization activity
GO:0051087 chaperone binding
GO:0055119 relaxation of cardiac muscle
GO:0060081 membrane hyperpolarization
GO:0060342 photoreceptor inner segment membrane
GO:0070062 extracellular exosome
GO:0071260 cellular response to mechanical stimulus
GO:0071383 cellular response to steroid hormone stimulus
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086004 regulation of cardiac muscle cell contraction
GO:0086009 membrane repolarization
GO:0086013 membrane repolarization during cardiac muscle cell action potential
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
GO:1902600 proton transmembrane transport
GO:1903416 response to glycoside
GO:1903561 extracellular vesicle
GO:1903779 regulation of cardiac conduction
GO:1990239 steroid hormone binding
GO:1990573 potassium ion import across plasma membrane

Subcellular Location

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Subcellular Location
Basolateral cell membrane
Cell membrane
Cell projection
Melanosome

Domains

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DomainNameCategoryType
IPR001757 P-type ATPaseFamilyFamily
IPR004014 Cation-transporting P-type ATPase, N-terminalDomainDomain
IPR005775 P-type ATPase subfamily IIC, subunit alphaFamilyFamily
IPR006068 Cation-transporting P-type ATPase, C-terminalDomainDomain
IPR008250 P-type ATPase, A domain superfamilyFamilyHomologous superfamily
IPR018303 P-type ATPase, phosphorylation sitePTMPTM
IPR023214 HAD superfamilyFamilyHomologous superfamily
IPR023298 P-type ATPase, transmembrane domain superfamilyFamilyHomologous superfamily
IPR023299 P-type ATPase, cytoplasmic domain NFamilyHomologous superfamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR044492 P-type ATPase, haloacid dehalogenase domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00390 DigoxinDrugbanksmall molecule
DB00511 AcetyldigitoxinDrugbanksmall molecule
DB00774 HydroflumethiazideDrugbanksmall molecule
DB00903 Etacrynic acidDrugbanksmall molecule
DB01021 TrichlormethiazideDrugbanksmall molecule
DB01078 DeslanosideDrugbanksmall molecule
DB01092 OuabainDrugbanksmall molecule
DB01119 DiazoxideDrugbanksmall molecule
DB01158 BretyliumDrugbanksmall molecule
DB01188 CiclopiroxDrugbanksmall molecule
DB01244 BepridilDrugbanksmall molecule
DB01345 Potassium cationDrugbanksmall molecule
DB01370 AluminiumDrugbanksmall molecule
DB01378 Magnesium cationDrugbanksmall molecule
DB01396 DigitoxinDrugbanksmall molecule
DB01430 AlmitrineDrugbanksmall molecule
DB06157 IstaroximeDrugbanksmall molecule
DB09479 Rubidium Rb-82Swissprotsmall molecule
DB13620 Potassium gluconateSwissprotsmall molecule
DB13749 Magnesium gluconateSwissprotsmall molecule
DB13996 Magnesium acetateDrugbanksmall molecule
DB14498 Potassium acetateDrugbanksmall molecule
DB14499 Potassium sulfateDrugbanksmall molecule
DB14500 PotassiumDrugbanksmall molecule
DB14514 Magnesium levulinateDrugbanksmall molecule
DB14515 Magnesium lactateDrugbanksmall molecule
DB14517 Aluminium phosphateDrugbanksmall molecule
DB14518 Aluminum acetateDrugbanksmall molecule

Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
AT1A1_HUMANMK03_HUMANBioGRID, HPRD15069082 details
AT1A1_HUMANEZH2_HUMANBioGRID, HPRD, IntAct16169070 details
AT1A1_HUMANKPCA_HUMANBioGRID15069082 details
AT1A1_HUMANMK01_HUMANBioGRID15069082 details
AT1A1_HUMANTCTP_HUMANHPRD, I2D, MINT15383549 16730713 21278788 details
AT1A1_HUMANSNAPN_HUMANBioGRID, IntAct23414517 details
AT1A1_HUMANZNRF2_HUMANBioGRID22797923 details
AT1A1_HUMANA2MG_HUMANBioGRID21163940 details
AT1A1_HUMANGPR35_HUMANBioGRID, MINT28298427 details
AT1A1_HUMANHGS_HUMANBioGRID19019082 details
AT1A1_HUMANZNRF1_HUMANBioGRID22797923 details
AT1A1_HUMANCOF1_HUMANHPRD11139403 details
AT1A1_HUMANAT1B1_HUMANBioGRID, IntAct25012180 26344197 30021884 31732153 details
AT1A1_HUMANPKD2_HUMANBioGRID11901144 details
AT1A1_HUMANSPRTN_HUMANBioGRID23254330 details
AT1A1_HUMANPLM_HUMANBioGRID, HPRD14597563 details
AT1A1_HUMANTNR1A_HUMANIntAct14743216 details
AT1A1_HUMANNELFA_HUMANBioGRID20305087 details
AT1A1_HUMANGPNMB_HUMANBioGRID27836549 details
AT1A1_HUMANSMAD2_HUMANIntAct20195357 details
AT1A1_HUMANTRPC6_HUMANBioGRID16025302 details
AT1A1_HUMANAP2A2_HUMANBioGRID20435073 details
AT1A1_HUMANNEPRO_HUMANBioGRID26472760 details
AT1A1_HUMANTNR1B_HUMANIntAct14743216 details
AT1A1_HUMANS12A1_HUMANBioGRID10903893 details
AT1A1_HUMANNELFD_HUMANBioGRID20305087 details
AT1A1_HUMANPKD1_HUMANBioGRID11901144 details
AT1A1_HUMANT2FB_HUMANIntAct20195357 details
AT1A1_HUMANTRADD_HUMANIntAct14743216 details
AT1A1_HUMANHDAC5_HUMANBioGRID21081666 details
AT1A1_HUMANCDK9_HUMANBioGRID20305087 27684187 details
AT1A1_HUMANADDA_HUMANHPRD10516168 details
AT1A1_HUMANLEG3_HUMANBioGRID24755837 details
AT1A1_HUMANSNX6_HUMANMINT16730713 details
AT1A1_HUMANAKT1_HUMANBioGRID16027165 details
AT1A1_HUMANISG15_HUMANBioGRID33024031 details
AT1A1_HUMANNELFB_HUMANBioGRID20305087 details
AT1A1_HUMANATP4A_HUMANBioGRID17255364 details
AT1A1_HUMANFXYD7_HUMANHPRD12093728 details