Entity Details

Primary name ALDOB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05062
EntryNameALDOB_HUMAN
FullNameFructose-bisphosphate aldolase B
TaxID9606
Evidenceevidence at protein level
Length364
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesALDOB

GO terms

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GOName
GO:0004332 fructose-bisphosphate aldolase activity
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0006000 fructose metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0006116 NADH oxidation
GO:0008092 cytoskeletal protein binding
GO:0030388 fructose 1,6-bisphosphate metabolic process
GO:0032781 positive regulation of ATPase activity
GO:0034451 centriolar satellite
GO:0042802 identical protein binding
GO:0051117 ATPase binding
GO:0061609 fructose-1-phosphate aldolase activity
GO:0061621 canonical glycolysis
GO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
GO:0070061 fructose binding
GO:0070062 extracellular exosome
GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000741 Fructose-bisphosphate aldolase, class-IFamilyFamily
IPR013785 Aldolase-type TIM barrelFamilyHomologous superfamily
IPR029768 Fructose-bisphosphate aldolase class-I active siteSiteConserved site

Diseases

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Disease IDSourceNameDescription
229600 OMIMHereditary fructose intolerance (HFI)Autosomal recessive disease that results in an inability to metabolize fructose and related sugars. Complete exclusion of fructose results in dramatic recovery; however, if not treated properly, HFI subjects suffer episodes of hypoglycemia, general ill condition, and risk of death the remainder of life. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB02512 1,6-Fructose Diphosphate (Linear Form)Drugbanksmall molecule
DB02515 sn-glycerol 3-phosphateDrugbanksmall molecule
DB04326 Dihydroxyacetone phosphateDrugbanksmall molecule

Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
ALDOB_HUMANBBS1_HUMANBioGRID, IntAct18000879 details
ALDOB_HUMANZEP1_HUMANBioGRID, IntAct21988832 details
ALDOB_HUMANBBS2_HUMANBioGRID, IntAct18000879 details
ALDOB_HUMANBBS4_HUMANBioGRID, IntAct18000879 details
ALDOB_HUMANAGT2_HUMANBioGRID, IntAct21988832 details
ALDOB_HUMANTHIOM_HUMANBioGRID, IntAct21988832 details
ALDOB_HUMANCTNA1_HUMANBioGRID, MINT24412244 details
ALDOB_HUMANBBS7_HUMANBioGRID, IntAct18000879 details
ALDOB_HUMANBUB1_HUMANBioGRID, MINT24412244 details
ALDOB_HUMANDCC_HUMANBioGRID, MINT24412244 details
ALDOB_HUMANMUC20_HUMANBioGRID, IntAct21988832 details
ALDOB_HUMANALDOA_HUMANBioGRID, IntAct21988832 details
ALDOB_HUMANMP2K4_HUMANBioGRID, MINT24412244 details
ALDOB_HUMANMLH3_HUMANBioGRID, MINT24412244 details
ALDOB_HUMANMLH1_HUMANBioGRID, MINT24412244 details
ALDOB_HUMANARF_HUMANBioGRID, MINT24412244 details
ALDOB_HUMANRASN_HUMANBioGRID, MINT24412244 details
ALDOB_HUMANSTK11_HUMANBioGRID, MINT24412244 details
ALDOB_HUMANBMR1A_HUMANBioGRID, MINT24412244 details
ALDOB_HUMANFLCN_HUMANBioGRID, MINT24412244 details
ALDOB_HUMANVATE1_HUMANBioGRID, HPRD11399750 details
ALDOB_HUMANCRCM_HUMANBioGRID, MINT24412244 details
ALDOB_HUMANA4_HUMANBioGRID21832049 details
ALDOB_HUMANCDN2A_HUMANBioGRID24412244 details
ALDOB_HUMANSMAD4_HUMANBioGRID, MINT24412244 details
ALDOB_HUMANSRC_HUMANBioGRID, MINT24412244 details
ALDOB_HUMANHUS1_HUMANIntAct17353931 details
ALDOB_HUMANALDOB_HUMANDIP, HPRD11679716 details
ALDOB_HUMANHSP7C_HUMANHPRD11241348 details