Entity Details

Primary name ISG15_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05161
EntryNameISG15_HUMAN
FullNameUbiquitin-like protein ISG15
TaxID9606
Evidenceevidence at protein level
Length165
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesISG15

GO terms

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GOName
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007229 integrin-mediated signaling pathway
GO:0009615 response to virus
GO:0016032 viral process
GO:0019941 modification-dependent protein catabolic process
GO:0019985 translesion synthesis
GO:0022627 cytosolic small ribosomal subunit
GO:0030501 positive regulation of bone mineralization
GO:0031386 protein tag
GO:0031397 negative regulation of protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0032020 ISG15-protein conjugation
GO:0032480 negative regulation of type I interferon production
GO:0032649 regulation of interferon-gamma production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0034340 response to type I interferon
GO:0042742 defense response to bacterium
GO:0045071 negative regulation of viral genome replication
GO:0045648 positive regulation of erythrocyte differentiation
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
GO:0060339 negative regulation of type I interferon-mediated signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR000626 Ubiquitin-like domainDomainDomain
IPR019956 Ubiquitin domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616126 OMIMImmunodeficiency 38, with basal ganglia calcification (IMD38)A primary immunodeficiency predisposing individuals to severe clinical disease upon infection with weakly virulent mycobacteria, including Mycobacterium bovis Bacille Calmette-Guerin (BCG) vaccines. Patients are also susceptible to Salmonella and Mycobacterium tubercolosis infections. Affected individuals have intracranial calcification. The disease is caused by variants affecting the gene represented in this entry.

Interactions

277 interactions

InteractorPartnerSourcesPublicationsLink
ISG15_HUMANUBP18_HUMANBioGRID, DIP, HPRD, IntAct16189514 25307056 25416956 30858391 31515488 32296183 details
ISG15_HUMANUBA7_HUMANBioGRID, DIP, HPRD, IntAct14976209 16009940 16169070 16189514 16884686 17597759 20975683 22693631 25416956 32296183 details
ISG15_HUMANPPM1B_HUMANBioGRID, MINT16872604 16884686 details
ISG15_HUMANPRKN_HUMANIntAct32814053 details
ISG15_HUMANUBP21_HUMANBioGRID21399617 details
ISG15_HUMANHDAC6_HUMANBioGRID25429107 details
ISG15_HUMANSQSTM_HUMANBioGRID25429107 33024031 details
ISG15_HUMANHIF1A_HUMANBioGRID24056783 details
ISG15_HUMANFLNB_HUMANBioGRID, MINT16009940 19270716 33024031 details
ISG15_HUMANNEDD4_HUMANBioGRID, DIP18287095 18305167 details
ISG15_HUMANATLA3_HUMANBioGRID, IntAct26259872 33024031 details
ISG15_HUMANBAP31_HUMANBioGRID, IntAct26259872 33024031 details
ISG15_HUMANTMM43_HUMANBioGRID, IntAct26259872 33024031 details
ISG15_HUMANPRKDC_HUMANBioGRID, IntAct26259872 33024031 details
ISG15_HUMANIRF3_HUMANIntAct32726803 details
ISG15_HUMANIFIH1_HUMANIntAct33727702 details
ISG15_HUMANSEPT2_HUMANBioGRID18305167 details
ISG15_HUMANUB2D3_HUMANBioGRID17719635 details
ISG15_HUMANRGS3_HUMANBioGRID16884686 details
ISG15_HUMANERCC2_HUMANBioGRID16884686 details
ISG15_HUMANHSP74_HUMANBioGRID16884686 details
ISG15_HUMANSTK38_HUMANBioGRID16884686 details
ISG15_HUMANFUT4_HUMANBioGRID16884686 details
ISG15_HUMANENOA_HUMANBioGRID16009940 16815975 16884686 33024031 details
ISG15_HUMANCHMP5_HUMANBioGRID16009940 20164219 details
ISG15_HUMANABCF2_HUMANBioGRID16009940 33024031 details
ISG15_HUMANACLY_HUMANBioGRID16009940 33024031 details
ISG15_HUMANACTN4_HUMANBioGRID16009940 33024031 details
ISG15_HUMANALDOA_HUMANBioGRID16009940 33024031 details
ISG15_HUMANAHNK_HUMANBioGRID16009940 33024031 details
ISG15_HUMANU520_HUMANBioGRID16009940 33024031 details
ISG15_HUMANATPA_HUMANBioGRID16009940 33024031 details
ISG15_HUMANATPB_HUMANBioGRID16009940 33024031 details
ISG15_HUMANATX2L_HUMANBioGRID16009940 33024031 details
ISG15_HUMANTCPB_HUMANBioGRID16009940 33024031 details
ISG15_HUMANTCPG_HUMANBioGRID16009940 33024031 details
ISG15_HUMANTCPD_HUMANBioGRID16009940 33024031 details
ISG15_HUMANCOF1_HUMANBioGRID16009940 16815975 details
ISG15_HUMANCLH1_HUMANBioGRID16009940 33024031 details
ISG15_HUMANDDX58_HUMANBioGRID16009940 29288164 details
ISG15_HUMANDDX17_HUMANBioGRID16009940 33024031 details
ISG15_HUMANEF2_HUMANBioGRID16009940 33024031 details
ISG15_HUMANIF4G1_HUMANBioGRID16009940 33024031 details
ISG15_HUMANFAS_HUMANBioGRID16009940 33024031 details
ISG15_HUMANMYOF_HUMANBioGRID16009940 33024031 details
ISG15_HUMANFLNA_HUMANBioGRID16009940 33024031 details
ISG15_HUMANG6PI_HUMANBioGRID16009940 33024031 details
ISG15_HUMANHERC5_HUMANBioGRID16009940 16815975 24693865 details
ISG15_HUMANHNRPL_HUMANBioGRID16009940 33024031 details
ISG15_HUMANHS71A_HUMANBioGRID16009940 33024031 details
ISG15_HUMANHS71B_HUMANBioGRID16009940 33024031 details
ISG15_HUMANHSP7C_HUMANBioGRID16009940 16815975 33024031 details
ISG15_HUMANHS90A_HUMANBioGRID16009940 33024031 details
ISG15_HUMANHS90B_HUMANBioGRID16009940 33024031 details
ISG15_HUMANCH60_HUMANBioGRID16009940 details
ISG15_HUMANIFIT1_HUMANBioGRID16009940 details
ISG15_HUMANLMNA_HUMANBioGRID16009940 33024031 details
ISG15_HUMANMOES_HUMANBioGRID16009940 details
ISG15_HUMANMX1_HUMANBioGRID16009940 details
ISG15_HUMANMYH9_HUMANBioGRID16009940 33024031 details
ISG15_HUMANPAIRB_HUMANBioGRID16009940 33024031 details
ISG15_HUMAN6PGD_HUMANBioGRID16009940 33024031 details
ISG15_HUMANPGK1_HUMANBioGRID16009940 33024031 details
ISG15_HUMANKPYM_HUMANBioGRID16009940 33024031 details
ISG15_HUMANPLEC_HUMANBioGRID16009940 33024031 details
ISG15_HUMANPRDX1_HUMANBioGRID16009940 16815975 details
ISG15_HUMANE2AK2_HUMANBioGRID16009940 33024031 details
ISG15_HUMANPTBP1_HUMANBioGRID16009940 details
ISG15_HUMANRAN_HUMANBioGRID16009940 33024031 details
ISG15_HUMANSPB5_HUMANBioGRID16009940 details
ISG15_HUMANSTAT1_HUMANBioGRID16009940 33024031 details
ISG15_HUMANTKT_HUMANBioGRID16009940 33024031 details
ISG15_HUMANTMOD3_HUMANBioGRID16009940 33024031 details
ISG15_HUMANTRXR1_HUMANBioGRID16009940 details
ISG15_HUMANUBE2N_HUMANBioGRID16009940 16112642 22693631 details
ISG15_HUMANTERA_HUMANBioGRID16009940 33024031 details
ISG15_HUMANVIME_HUMANBioGRID16009940 33024031 details
ISG15_HUMANSYWC_HUMANBioGRID16009940 33024031 details
ISG15_HUMANTRI25_HUMANBioGRID17222803 details
ISG15_HUMAN1433S_HUMANBioGRID17222803 details
ISG15_HUMANDEST_HUMANBioGRID16815975 details
ISG15_HUMANG3P_HUMANBioGRID16815975 33024031 details
ISG15_HUMANHSPB1_HUMANBioGRID16815975 33024031 details
ISG15_HUMANPRDX6_HUMANBioGRID16815975 details
ISG15_HUMANCTNB1_HUMANBioGRID20581239 details
ISG15_HUMANLRC25_HUMANBioGRID29288164 details
ISG15_HUMANATG5_HUMANBioGRID33024031 details
ISG15_HUMANACTB_HUMANBioGRID33024031 details
ISG15_HUMANACTBL_HUMANBioGRID33024031 details
ISG15_HUMANACTC_HUMANBioGRID33024031 details
ISG15_HUMANACTG_HUMANBioGRID33024031 details
ISG15_HUMANAHNK2_HUMANBioGRID33024031 details
ISG15_HUMANAIMP1_HUMANBioGRID33024031 details
ISG15_HUMANAK1BA_HUMANBioGRID33024031 details
ISG15_HUMANAK1C2_HUMANBioGRID33024031 details
ISG15_HUMANAK1C3_HUMANBioGRID33024031 details
ISG15_HUMANAL1A1_HUMANBioGRID33024031 details
ISG15_HUMANANXA1_HUMANBioGRID33024031 details
ISG15_HUMANAP2A1_HUMANBioGRID33024031 details
ISG15_HUMANAP2A2_HUMANBioGRID33024031 details
ISG15_HUMANAP2B1_HUMANBioGRID33024031 details
ISG15_HUMANAP2M1_HUMANBioGRID33024031 details
ISG15_HUMANARF4_HUMANBioGRID33024031 details
ISG15_HUMANASCC3_HUMANBioGRID33024031 details
ISG15_HUMANAT131_HUMANBioGRID33024031 details
ISG15_HUMANAT1A1_HUMANBioGRID33024031 details
ISG15_HUMANAT2A2_HUMANBioGRID33024031 details
ISG15_HUMANAT2B1_HUMANBioGRID33024031 details
ISG15_HUMANBCLF1_HUMANBioGRID33024031 details
ISG15_HUMANBMP2K_HUMANBioGRID33024031 details
ISG15_HUMANBRX1_HUMANBioGRID33024031 details
ISG15_HUMANC1QBP_HUMANBioGRID33024031 details
ISG15_HUMANPYR1_HUMANBioGRID33024031 details
ISG15_HUMANCAND1_HUMANBioGRID33024031 details
ISG15_HUMANCALX_HUMANBioGRID33024031 details
ISG15_HUMANCAV1_HUMANBioGRID33024031 details
ISG15_HUMANTCPZ_HUMANBioGRID33024031 details
ISG15_HUMANTCPQ_HUMANBioGRID33024031 details
ISG15_HUMANCDK3_HUMANBioGRID33024031 details
ISG15_HUMANCKAP4_HUMANBioGRID33024031 details
ISG15_HUMANEPN4_HUMANBioGRID33024031 details
ISG15_HUMANCLPT1_HUMANBioGRID33024031 details
ISG15_HUMANCOPA_HUMANBioGRID33024031 details
ISG15_HUMANCOPB2_HUMANBioGRID33024031 details
ISG15_HUMANXPO2_HUMANBioGRID33024031 details
ISG15_HUMANDAB2_HUMANBioGRID33024031 details
ISG15_HUMANSYDC_HUMANBioGRID33024031 details
ISG15_HUMANDDB1_HUMANBioGRID33024031 details
ISG15_HUMANDDX1_HUMANBioGRID33024031 details
ISG15_HUMANDDX23_HUMANBioGRID33024031 details
ISG15_HUMANDX39A_HUMANBioGRID33024031 details
ISG15_HUMANDX39B_HUMANBioGRID33024031 details
ISG15_HUMANDDX3X_HUMANBioGRID33024031 details
ISG15_HUMANDDX54_HUMANBioGRID33024031 details
ISG15_HUMANDHX15_HUMANBioGRID33024031 details
ISG15_HUMANDHX30_HUMANBioGRID33024031 details
ISG15_HUMANDHX9_HUMANBioGRID33024031 details
ISG15_HUMAND19L1_HUMANBioGRID33024031 details
ISG15_HUMANDSG2_HUMANBioGRID33024031 details
ISG15_HUMANDYHC1_HUMANBioGRID33024031 details
ISG15_HUMANU5S1_HUMANBioGRID33024031 details
ISG15_HUMANEMC1_HUMANBioGRID33024031 details
ISG15_HUMANHYEP_HUMANBioGRID33024031 details
ISG15_HUMANSYEP_HUMANBioGRID33024031 details
ISG15_HUMANERLN1_HUMANBioGRID33024031 details
ISG15_HUMANERMP1_HUMANBioGRID33024031 details
ISG15_HUMANFA98A_HUMANBioGRID33024031 details
ISG15_HUMANFLII_HUMANBioGRID33024031 details
ISG15_HUMANFLOT1_HUMANBioGRID33024031 details
ISG15_HUMANFLOT2_HUMANBioGRID33024031 details
ISG15_HUMANSPB1_HUMANBioGRID33024031 details
ISG15_HUMANGALT2_HUMANBioGRID33024031 details
ISG15_HUMANGCN1_HUMANBioGRID33024031 details
ISG15_HUMANGNL3_HUMANBioGRID33024031 details
ISG15_HUMANGELS_HUMANBioGRID33024031 details
ISG15_HUMANGULP1_HUMANBioGRID33024031 details
ISG15_HUMANHACD3_HUMANBioGRID33024031 details
ISG15_HUMANROA3_HUMANBioGRID33024031 details
ISG15_HUMANHNRPF_HUMANBioGRID33024031 details
ISG15_HUMANHNRPM_HUMANBioGRID33024031 details
ISG15_HUMANHP1B3_HUMANBioGRID33024031 details
ISG15_HUMANSYIC_HUMANBioGRID33024031 details
ISG15_HUMANIBTK_HUMANBioGRID33024031 details
ISG15_HUMANILF3_HUMANBioGRID33024031 details
ISG15_HUMANMIC60_HUMANBioGRID33024031 details
ISG15_HUMANJAK1_HUMANBioGRID33024031 details
ISG15_HUMANIMA1_HUMANBioGRID33024031 details
ISG15_HUMANK1C19_HUMANBioGRID33024031 details
ISG15_HUMANKRT81_HUMANBioGRID33024031 details
ISG15_HUMANK1C9_HUMANBioGRID33024031 details
ISG15_HUMANSYLC_HUMANBioGRID33024031 details
ISG15_HUMANLDHB_HUMANBioGRID33024031 details
ISG15_HUMANLIMC1_HUMANBioGRID33024031 details
ISG15_HUMANLMAN1_HUMANBioGRID33024031 details
ISG15_HUMANLMO7_HUMANBioGRID33024031 details
ISG15_HUMANLRC59_HUMANBioGRID33024031 details
ISG15_HUMANLRRF2_HUMANBioGRID33024031 details
ISG15_HUMANLUZP1_HUMANBioGRID33024031 details
ISG15_HUMANLYAR_HUMANBioGRID33024031 details
ISG15_HUMANSYMC_HUMANBioGRID33024031 details
ISG15_HUMANMATR3_HUMANBioGRID33024031 details
ISG15_HUMANMISP_HUMANBioGRID33024031 details
ISG15_HUMANMPRIP_HUMANBioGRID33024031 details
ISG15_HUMANMRT4_HUMANBioGRID33024031 details
ISG15_HUMANLYRIC_HUMANBioGRID33024031 details
ISG15_HUMANC1TC_HUMANBioGRID33024031 details
ISG15_HUMANMBB1A_HUMANBioGRID33024031 details
ISG15_HUMANMYH10_HUMANBioGRID33024031 details
ISG15_HUMANMYH7B_HUMANBioGRID33024031 details
ISG15_HUMANML12B_HUMANBioGRID33024031 details
ISG15_HUMANML12A_HUMANBioGRID33024031 details
ISG15_HUMANMYL6_HUMANBioGRID33024031 details
ISG15_HUMANMYL6B_HUMANBioGRID33024031 details
ISG15_HUMANMY18A_HUMANBioGRID33024031 details
ISG15_HUMANMYO1B_HUMANBioGRID33024031 details
ISG15_HUMANMYO1C_HUMANBioGRID33024031 details
ISG15_HUMANMYO1E_HUMANBioGRID33024031 details
ISG15_HUMANMYO5A_HUMANBioGRID33024031 details
ISG15_HUMANMYO5C_HUMANBioGRID33024031 details
ISG15_HUMANMYO6_HUMANBioGRID33024031 details
ISG15_HUMANNP1L1_HUMANBioGRID33024031 details
ISG15_HUMANNAT10_HUMANBioGRID33024031 details
ISG15_HUMANNU205_HUMANBioGRID33024031 details
ISG15_HUMANPABP1_HUMANBioGRID33024031 details
ISG15_HUMANPARP1_HUMANBioGRID33024031 details
ISG15_HUMANPCBP1_HUMANBioGRID33024031 details
ISG15_HUMANPCM1_HUMANBioGRID33024031 details
ISG15_HUMANPGRC2_HUMANBioGRID33024031 details
ISG15_HUMANPHB2_HUMANBioGRID33024031 details
ISG15_HUMANPICAL_HUMANBioGRID33024031 details
ISG15_HUMANNCPR_HUMANBioGRID33024031 details
ISG15_HUMANPPIA_HUMANBioGRID33024031 details
ISG15_HUMANPP1B_HUMANBioGRID33024031 details
ISG15_HUMANMYPT1_HUMANBioGRID33024031 details
ISG15_HUMANPRP8_HUMANBioGRID33024031 details
ISG15_HUMANPRC2C_HUMANBioGRID33024031 details
ISG15_HUMANPSMD3_HUMANBioGRID33024031 details
ISG15_HUMANSYQ_HUMANBioGRID33024031 details
ISG15_HUMANRB11A_HUMANBioGRID33024031 details
ISG15_HUMANRAI14_HUMANBioGRID33024031 details
ISG15_HUMANSYRC_HUMANBioGRID33024031 details
ISG15_HUMANRBM25_HUMANBioGRID33024031 details
ISG15_HUMANRBM28_HUMANBioGRID33024031 details
ISG15_HUMANRL13A_HUMANBioGRID33024031 details
ISG15_HUMANRL23A_HUMANBioGRID33024031 details
ISG15_HUMANOST48_HUMANBioGRID33024031 details
ISG15_HUMANRS26_HUMANBioGRID33024031 details
ISG15_HUMANRL1D1_HUMANBioGRID33024031 details
ISG15_HUMANRUVB1_HUMANBioGRID33024031 details
ISG15_HUMANRUVB2_HUMANBioGRID33024031 details
ISG15_HUMANSC16A_HUMANBioGRID33024031 details
ISG15_HUMANSERPH_HUMANBioGRID33024031 details
ISG15_HUMANSF3B3_HUMANBioGRID33024031 details
ISG15_HUMANMPCP_HUMANBioGRID33024031 details
ISG15_HUMANADT3_HUMANBioGRID33024031 details
ISG15_HUMAN4F2_HUMANBioGRID33024031 details
ISG15_HUMANSND1_HUMANBioGRID33024031 details
ISG15_HUMANSPAS2_HUMANBioGRID33024031 details
ISG15_HUMANSPS2L_HUMANBioGRID33024031 details
ISG15_HUMANCYTSA_HUMANBioGRID33024031 details
ISG15_HUMANSPTN1_HUMANBioGRID33024031 details
ISG15_HUMANSQOR_HUMANBioGRID33024031 details
ISG15_HUMANSRPK1_HUMANBioGRID33024031 details
ISG15_HUMANSRSF1_HUMANBioGRID33024031 details
ISG15_HUMANSRSF3_HUMANBioGRID33024031 details
ISG15_HUMANSSRP1_HUMANBioGRID33024031 details
ISG15_HUMANSTAU1_HUMANBioGRID33024031 details
ISG15_HUMANSP16H_HUMANBioGRID33024031 details
ISG15_HUMANTAP1_HUMANBioGRID33024031 details
ISG15_HUMANTPSN_HUMANBioGRID33024031 details
ISG15_HUMANTBL2_HUMANBioGRID33024031 details
ISG15_HUMANTCPA_HUMANBioGRID33024031 details
ISG15_HUMANTFR1_HUMANBioGRID33024031 details
ISG15_HUMANTR150_HUMANBioGRID33024031 details
ISG15_HUMANTIM50_HUMANBioGRID33024031 details
ISG15_HUMANZO1_HUMANBioGRID33024031 details
ISG15_HUMANTM9S2_HUMANBioGRID33024031 details
ISG15_HUMANTM9S3_HUMANBioGRID33024031 details
ISG15_HUMANLAP2A_HUMANBioGRID33024031 details
ISG15_HUMANLAP2B_HUMANBioGRID33024031 details
ISG15_HUMANTOP2B_HUMANBioGRID33024031 details
ISG15_HUMANP63_HUMANBioGRID33024031 details
ISG15_HUMANTPM1_HUMANBioGRID33024031 details
ISG15_HUMANTPM2_HUMANBioGRID33024031 details
ISG15_HUMANTPM3_HUMANBioGRID33024031 details
ISG15_HUMANTPM4_HUMANBioGRID33024031 details
ISG15_HUMANTRAF2_HUMANBioGRID33024031 details
ISG15_HUMANTBB3_HUMANBioGRID33024031 details
ISG15_HUMANTBB6_HUMANBioGRID33024031 details
ISG15_HUMANU2AF2_HUMANBioGRID33024031 details
ISG15_HUMANUACA_HUMANBioGRID33024031 details
ISG15_HUMANUBF1_HUMANBioGRID33024031 details
ISG15_HUMANUGDH_HUMANBioGRID33024031 details
ISG15_HUMANVAPA_HUMANBioGRID33024031 details
ISG15_HUMANYBOX1_HUMANBioGRID33024031 details
ISG15_HUMAN1433B_HUMANBioGRID33024031 details
ISG15_HUMANFACE1_HUMANBioGRID33024031 details