Entity Details

Primary name GELS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06396
EntryNameGELS_HUMAN
FullNameGelsolin
TaxID9606
Evidenceevidence at protein level
Length782
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesGSN

GO terms

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GOName
GO:0001726 ruffle
GO:0002102 podosome
GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006911 phagocytosis, engulfment
GO:0007417 central nervous system development
GO:0007568 aging
GO:0008154 actin polymerization or depolymerization
GO:0010628 positive regulation of gene expression
GO:0014003 oligodendrocyte development
GO:0014891 striated muscle atrophy
GO:0015629 actin cytoskeleton
GO:0016528 sarcoplasm
GO:0030027 lamellipodium
GO:0030031 cell projection assembly
GO:0030041 actin filament polymerization
GO:0030042 actin filament depolymerization
GO:0030155 regulation of cell adhesion
GO:0030478 actin cap
GO:0030864 cortical actin cytoskeleton
GO:0031648 protein destabilization
GO:0032991 protein-containing complex
GO:0034774 secretory granule lumen
GO:0035994 response to muscle stretch
GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding
GO:0042060 wound healing
GO:0042246 tissue regeneration
GO:0042989 sequestering of actin monomers
GO:0043209 myelin sheath
GO:0043312 neutrophil degranulation
GO:0045010 actin nucleation
GO:0045159 myosin II binding
GO:0045335 phagocytic vesicle
GO:0045471 response to ethanol
GO:0046597 negative regulation of viral entry into host cell
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048471 perinuclear region of cytoplasm
GO:0051014 actin filament severing
GO:0051015 actin filament binding
GO:0051016 barbed-end actin filament capping
GO:0051127 positive regulation of actin nucleation
GO:0051593 response to folic acid
GO:0051693 actin filament capping
GO:0055119 relaxation of cardiac muscle
GO:0060271 cilium assembly
GO:0070062 extracellular exosome
GO:0071276 cellular response to cadmium ion
GO:0071346 cellular response to interferon-gamma
GO:0071801 regulation of podosome assembly
GO:0072562 blood microparticle
GO:0086003 cardiac muscle cell contraction
GO:0090527 actin filament reorganization
GO:0097017 renal protein absorption
GO:0097284 hepatocyte apoptotic process
GO:1902174 positive regulation of keratinocyte apoptotic process
GO:1903903 regulation of establishment of T cell polarity
GO:1903906 regulation of plasma membrane raft polarization
GO:1903909 regulation of receptor clustering
GO:1903923 positive regulation of protein processing in phagocytic vesicle
GO:1904813 ficolin-1-rich granule lumen
GO:1990000 amyloid fibril formation
GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR007122 Villin/GelsolinFamilyFamily
IPR007123 Gelsolin-like domainDomainDomain
IPR029006 ADF-H/Gelsolin-like domain superfamilyFamilyHomologous superfamily
IPR030004 GelsolinFamilyFamily

Diseases

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Disease IDSourceNameDescription
105120 OMIMAmyloidosis 5 (AMYL5)A hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB02621 Latrunculin ADrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule

Interactions

230 interactions

InteractorPartnerSourcesPublicationsLink
GELS_HUMANACTS_HUMANBioGRID, HPRD, MINT10583954 10854330 8395021 details
GELS_HUMANTM1L1_HUMANBioGRID, HPRD, IntAct16169070 details
GELS_HUMANEGFR_HUMANIntAct20029029 31980649 details
GELS_HUMANCDK2_HUMANBioGRID, IntAct26496610 32814053 details
GELS_HUMANANDR_HUMANBioGRID, DIP, HPRD12941811 15604093 19574450 details
GELS_HUMANPCNA_HUMANUniProt26030842 details
GELS_HUMANERBB2_HUMANBioGRID, IntAct31980649 details
GELS_HUMANMYC_HUMANIntAct32814053 details
GELS_HUMANEM55_HUMANIntAct32814053 details
GELS_HUMANMCM7_HUMANIntAct32814053 details
GELS_HUMANAOFB_HUMANIntAct32814053 details
GELS_HUMANLASP1_HUMANIntAct32814053 details
GELS_HUMANKT33B_HUMANIntAct32814053 details
GELS_HUMANK1C19_HUMANIntAct32814053 details
GELS_HUMANJUN_HUMANIntAct32814053 details
GELS_HUMANIBP4_HUMANIntAct32814053 details
GELS_HUMANID1_HUMANIntAct32814053 details
GELS_HUMAN3BHS1_HUMANIntAct32814053 details
GELS_HUMANGATA1_HUMANIntAct32814053 details
GELS_HUMANGABP1_HUMANIntAct32814053 details
GELS_HUMANFOSL2_HUMANIntAct32814053 details
GELS_HUMANHBEGF_HUMANIntAct32814053 details
GELS_HUMANDPYS_HUMANIntAct32814053 details
GELS_HUMANCOMT_HUMANIntAct32814053 details
GELS_HUMANCO2A1_HUMANIntAct32814053 details
GELS_HUMANCDN1A_HUMANIntAct32814053 details
GELS_HUMANCAN3_HUMANIntAct32814053 details
GELS_HUMANBCAT1_HUMANIntAct32814053 details
GELS_HUMANTRI23_HUMANIntAct32814053 details
GELS_HUMANAIF1_HUMANIntAct32814053 details
GELS_HUMANPRKN_HUMANIntAct32814053 details
GELS_HUMANNFE2_HUMANIntAct32814053 details
GELS_HUMANNEDD8_HUMANIntAct32814053 details
GELS_HUMANNCF1_HUMANIntAct32814053 details
GELS_HUMANMYPT2_HUMANIntAct32814053 details
GELS_HUMANPPARA_HUMANIntAct32814053 details
GELS_HUMANUPAR_HUMANIntAct32814053 details
GELS_HUMANPER1_HUMANIntAct32814053 details
GELS_HUMANKHDC4_HUMANIntAct32814053 details
GELS_HUMANDUS10_HUMANIntAct32814053 details
GELS_HUMANRBL2B_HUMANIntAct32814053 details
GELS_HUMANRBP1_HUMANIntAct32814053 details
GELS_HUMANBATF_HUMANIntAct32814053 details
GELS_HUMANPPIE_HUMANIntAct32814053 details
GELS_HUMANMCRS1_HUMANIntAct32814053 details
GELS_HUMANTI17B_HUMANIntAct32814053 details
GELS_HUMANAKAP9_HUMANIntAct32814053 details
GELS_HUMANTOB1_HUMANIntAct32814053 details
GELS_HUMANTSN2_HUMANIntAct32814053 details
GELS_HUMANELL2_HUMANIntAct32814053 details
GELS_HUMANBAHD1_HUMANIntAct32814053 details
GELS_HUMANNR1D2_HUMANIntAct32814053 details
GELS_HUMANFCSD2_HUMANIntAct32814053 details
GELS_HUMANSOCS6_HUMANIntAct32814053 details
GELS_HUMANDNJA3_HUMANIntAct32814053 details
GELS_HUMANCCN4_HUMANIntAct32814053 details
GELS_HUMANCDS2_HUMANIntAct32814053 details
GELS_HUMANTELT_HUMANIntAct32814053 details
GELS_HUMANGO45_HUMANIntAct32814053 details
GELS_HUMANCBX4_HUMANIntAct32814053 details
GELS_HUMANDPF1_HUMANIntAct32814053 details
GELS_HUMANFOSL1_HUMANIntAct32814053 details
GELS_HUMANZBT14_HUMANIntAct32814053 details
GELS_HUMANWNT7A_HUMANIntAct32814053 details
GELS_HUMANUB2V1_HUMANIntAct32814053 details
GELS_HUMANUBE2A_HUMANIntAct32814053 details
GELS_HUMANTSNAX_HUMANIntAct32814053 details
GELS_HUMANTERF1_HUMANIntAct32814053 details
GELS_HUMANTBCC_HUMANIntAct32814053 details
GELS_HUMANITPI2_HUMANIntAct32814053 details
GELS_HUMANSP2_HUMANIntAct32814053 details
GELS_HUMANSNF5_HUMANIntAct32814053 details
GELS_HUMANRS15A_HUMANIntAct32814053 details
GELS_HUMANRS4X_HUMANIntAct32814053 details
GELS_HUMANRL31_HUMANIntAct32814053 details
GELS_HUMANRGR_HUMANIntAct32814053 details
GELS_HUMANTF65_HUMANIntAct32814053 details
GELS_HUMANPSME1_HUMANIntAct32814053 details
GELS_HUMANAAKB2_HUMANIntAct32814053 details
GELS_HUMANMET7A_HUMANIntAct32814053 details
GELS_HUMANNGEF_HUMANIntAct32814053 details
GELS_HUMANAR2BP_HUMANIntAct32814053 details
GELS_HUMANLAT2_HUMANIntAct32814053 details
GELS_HUMANPLCL2_HUMANIntAct32814053 details
GELS_HUMANCIA2B_HUMANIntAct32814053 details
GELS_HUMANH1BP3_HUMANIntAct32814053 details
GELS_HUMANLHX5_HUMANIntAct32814053 details
GELS_HUMANIFG15_HUMANIntAct32814053 details
GELS_HUMANRT14_HUMANIntAct32814053 details
GELS_HUMANMIIP_HUMANIntAct32814053 details
GELS_HUMANSEM4G_HUMANIntAct32814053 details
GELS_HUMANAT7L1_HUMANIntAct32814053 details
GELS_HUMANSPRY7_HUMANIntAct32814053 details
GELS_HUMANPAR11_HUMANIntAct32814053 details
GELS_HUMANOTU7B_HUMANIntAct32814053 details
GELS_HUMANDPYL5_HUMANIntAct32814053 details
GELS_HUMANAKIP1_HUMANIntAct32814053 details
GELS_HUMANVPS11_HUMANIntAct32814053 details
GELS_HUMANRCOR3_HUMANIntAct32814053 details
GELS_HUMANLURA1_HUMANIntAct32814053 details
GELS_HUMANASIC4_HUMANIntAct32814053 details
GELS_HUMANAGGF1_HUMANIntAct32814053 details
GELS_HUMANLTOR1_HUMANIntAct32814053 details
GELS_HUMANARH38_HUMANIntAct32814053 details
GELS_HUMANWBP1L_HUMANIntAct32814053 details
GELS_HUMANTET2_HUMANIntAct32814053 details
GELS_HUMANATL4_HUMANIntAct32814053 details
GELS_HUMANTM6S1_HUMANIntAct32814053 details
GELS_HUMANMYOZ2_HUMANIntAct32814053 details
GELS_HUMANZN581_HUMANIntAct32814053 details
GELS_HUMANVPS54_HUMANIntAct32814053 details
GELS_HUMANNO40_HUMANIntAct32814053 details
GELS_HUMANRN138_HUMANIntAct32814053 details
GELS_HUMANTHEG_HUMANIntAct32814053 details
GELS_HUMANDHB12_HUMANIntAct32814053 details
GELS_HUMANRPAC2_HUMANIntAct32814053 details
GELS_HUMANRPA12_HUMANIntAct32814053 details
GELS_HUMANMOG1_HUMANIntAct32814053 details
GELS_HUMANDBNL_HUMANIntAct32814053 details
GELS_HUMANKLH20_HUMANIntAct32814053 details
GELS_HUMANIL37_HUMANIntAct32814053 details
GELS_HUMANBRPF3_HUMANIntAct32814053 details
GELS_HUMANKLHL3_HUMANIntAct32814053 details
GELS_HUMANFA83A_HUMANIntAct32814053 details
GELS_HUMANIQGA3_HUMANIntAct32814053 details
GELS_HUMANISCA2_HUMANIntAct32814053 details
GELS_HUMANODAD3_HUMANIntAct32814053 details
GELS_HUMANTET5B_HUMANIntAct32814053 details
GELS_HUMANHAUS1_HUMANIntAct32814053 details
GELS_HUMANATIF1_HUMANIntAct32814053 details
GELS_HUMANWDR20_HUMANIntAct32814053 details
GELS_HUMANCHMP7_HUMANIntAct32814053 details
GELS_HUMANMSD3_HUMANIntAct32814053 details
GELS_HUMANIFT20_HUMANIntAct32814053 details
GELS_HUMANPP16A_HUMANIntAct32814053 details
GELS_HUMANRAB2B_HUMANIntAct32814053 details
GELS_HUMANZN333_HUMANIntAct32814053 details
GELS_HUMANLOXL4_HUMANIntAct32814053 details
GELS_HUMANTEX35_HUMANIntAct32814053 details
GELS_HUMANTMTC1_HUMANIntAct32814053 details
GELS_HUMANUCK1_HUMANIntAct32814053 details
GELS_HUMANSPY4_HUMANIntAct32814053 details
GELS_HUMANNETO2_HUMANIntAct32814053 details
GELS_HUMANNDEL1_HUMANIntAct32814053 details
GELS_HUMANZN436_HUMANIntAct32814053 details
GELS_HUMANCC036_HUMANIntAct32814053 details
GELS_HUMANPAAT_HUMANIntAct32814053 details
GELS_HUMANPKHS1_HUMANIntAct32814053 details
GELS_HUMANMRM1_HUMANIntAct32814053 details
GELS_HUMANACBD4_HUMANIntAct32814053 details
GELS_HUMANKCD17_HUMANIntAct32814053 details
GELS_HUMANE2F8_HUMANIntAct32814053 details
GELS_HUMANHBAP1_HUMANIntAct32814053 details
GELS_HUMANHECD3_HUMANIntAct32814053 details
GELS_HUMANF184A_HUMANIntAct32814053 details
GELS_HUMANPHF23_HUMANIntAct32814053 details
GELS_HUMANTMUB2_HUMANIntAct32814053 details
GELS_HUMANCLUP3_HUMANIntAct32814053 details
GELS_HUMANAUNIP_HUMANIntAct32814053 details
GELS_HUMANLYNX1_HUMANIntAct32814053 details
GELS_HUMANCOA7_HUMANIntAct32814053 details
GELS_HUMANCCD14_HUMANIntAct32814053 details
GELS_HUMANPALS1_HUMANIntAct32814053 details
GELS_HUMANCHST8_HUMANIntAct32814053 details
GELS_HUMANSTX19_HUMANIntAct32814053 details
GELS_HUMANZN829_HUMANIntAct32814053 details
GELS_HUMANSPT12_HUMANIntAct32814053 details
GELS_HUMANGUSP1_HUMANIntAct32814053 details
GELS_HUMANBEX5_HUMANIntAct32814053 details
GELS_HUMANCL074_HUMANIntAct32814053 details
GELS_HUMANKR197_HUMANIntAct32814053 details
GELS_HUMANKR195_HUMANIntAct32814053 details
GELS_HUMANNSE2_HUMANIntAct32814053 details
GELS_HUMANCC141_HUMANIntAct32814053 details
GELS_HUMANRIMKA_HUMANIntAct32814053 details
GELS_HUMANRUAS1_HUMANIntAct32814053 details
GELS_HUMANCF218_HUMANIntAct32814053 details
GELS_HUMANSPAS1_HUMANIntAct32814053 details
GELS_HUMANSPA24_HUMANIntAct32814053 details
GELS_HUMANTMM61_HUMANIntAct32814053 details
GELS_HUMANRBM46_HUMANIntAct32814053 details
GELS_HUMANLONF2_HUMANIntAct32814053 details
GELS_HUMANIQUB_HUMANIntAct32814053 details
GELS_HUMANDPPA2_HUMANIntAct32814053 details
GELS_HUMANF163A_HUMANIntAct32814053 details
GELS_HUMANTRI69_HUMANIntAct32814053 details
GELS_HUMANVP37A_HUMANIntAct32814053 details
GELS_HUMANPPR21_HUMANIntAct32814053 details
GELS_HUMANSTK39_HUMANBioGRID14563843 details
GELS_HUMANFAK2_HUMANBioGRID, HPRD12578912 details
GELS_HUMANFINC_HUMANBioGRID, HPRD23750785 6092370 details
GELS_HUMANA4_HUMANBioGRID, HPRD10329371 details
GELS_HUMANPLCG1_HUMANBioGRID9164868 details
GELS_HUMANACTN4_HUMANBioGRID, HPRD11733011 details
GELS_HUMANCASP3_HUMANBioGRID, HPRD18723680 9323209 9671712 details
GELS_HUMANHS90A_HUMANBioGRID31273033 details
GELS_HUMANARRB1_HUMANBioGRID, IntAct17620599 details
GELS_HUMANARRB2_HUMANBioGRID, IntAct17620599 details
GELS_HUMANESR1_HUMANBioGRID, IntAct20308691 21182205 25604459 details
GELS_HUMANIDLC_HUMANBioGRID, IntAct27173435 unassigned1312 details
GELS_HUMANEIF3K_HUMANBioGRID, IntAct27173435 unassigned1312 details
GELS_HUMANSESD1_HUMANBioGRID, IntAct27173435 unassigned1312 details
GELS_HUMANPROF2_HUMANBioGRID, IntAct27173435 unassigned1312 details
GELS_HUMANDISC1_HUMANBioGRID, MINT29961565 details
GELS_HUMANVDAC1_HUMANBioGRID, HPRD11039896 details
GELS_HUMANPK3CA_HUMANBioGRID11577104 details
GELS_HUMANFAK1_HUMANBioGRID11577104 details
GELS_HUMANVINC_HUMANBioGRID, HPRD11577104 details
GELS_HUMANPAXI_HUMANBioGRID, HPRD11577104 details
GELS_HUMANSRC_HUMANBioGRID11577104 details
GELS_HUMANPTN12_HUMANBioGRID11577104 details
GELS_HUMANPSMD4_HUMANBioGRID12601813 details
GELS_HUMANUB2Q2_HUMANBioGRID16300736 details
GELS_HUMANMDM2_HUMANBioGRID17373842 details
GELS_HUMAN3MG_HUMANBioGRID23537643 details
GELS_HUMANWASL_HUMANBioGRID16531231 details
GELS_HUMANCFLAR_HUMANBioGRID25246592 details
GELS_HUMANITCH_HUMANBioGRID25246592 details
GELS_HUMANACTB_HUMANBioGRID, HPRD10945978 15215896 details
GELS_HUMANDTNA_HUMANBioGRID20111909 details
GELS_HUMANISG15_HUMANBioGRID33024031 details
GELS_HUMANFHIT_HUMANHPRD12833632 details
GELS_HUMANCSK_HUMANHPRD10210201 details
GELS_HUMANPK3CG_HUMANHPRD11577104 details
GELS_HUMANVASP_HUMANHPRD11093254 details
GELS_HUMANLIMK2_HUMANHPRD11171090 details
GELS_HUMANBCAR1_HUMANHPRD11577104 details
GELS_HUMANCLIC5_HUMANHPRD10793131 details
GELS_HUMANTNIK_HUMANHPRD10521462 details
GELS_HUMANACTG_HUMANHPRD11733011 7849017 details