Entity Details

Primary name LDHB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07195
EntryNameLDHB_HUMAN
FullNameL-lactate dehydrogenase B chain
TaxID9606
Evidenceevidence at protein level
Length334
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesLDHB

GO terms

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GOName
GO:0004459 L-lactate dehydrogenase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005975 carbohydrate metabolic process
GO:0006090 pyruvate metabolic process
GO:0016020 membrane
GO:0042802 identical protein binding
GO:0045121 membrane raft
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR001236 Lactate/malate dehydrogenase, N-terminalDomainDomain
IPR001557 L-lactate/malate dehydrogenaseFamilyFamily
IPR011304 L-lactate dehydrogenaseFamilyFamily
IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminalFamilyHomologous superfamily
IPR018177 L-lactate dehydrogenase, active siteSiteActive site
IPR022383 Lactate/malate dehydrogenase, C-terminalDomainDomain
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614128 OMIMLactate dehydrogenase B deficiency (LDHBD)A condition with no deleterious effects on health. LDHBD is of interest to laboratory medicine mainly because it can cause misdiagnosis in those disorders in which elevation of serum LDH is expected. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB02401 4-Hydroxy-1,2,5-oxadiazole-3-carboxylic acidDrugbanksmall molecule
DB03940 Oxamic AcidDrugbanksmall molecule
DB09118 StiripentolDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule