Entity Details

Primary name PERT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07202
EntryNamePERT_HUMAN
FullNameThyroid peroxidase
TaxID9606
Evidenceevidence at protein level
Length933
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesTPO

GO terms

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GOName
GO:0004447 iodide peroxidase activity
GO:0004601 peroxidase activity
GO:0005509 calcium ion binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006590 thyroid hormone generation
GO:0006979 response to oxidative stress
GO:0009986 cell surface
GO:0020037 heme binding
GO:0035162 embryonic hemopoiesis
GO:0042446 hormone biosynthetic process
GO:0042744 hydrogen peroxide catabolic process

Subcellular Location

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Subcellular Location
Cell surface
Membrane

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000436 Sushi/SCR/CCP domainDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR010255 Haem peroxidase superfamilyFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR019791 Haem peroxidase, animal-typeFamilyFamily
IPR029589 Thyroid peroxidaseFamilyFamily
IPR035976 Sushi/SCR/CCP superfamilyFamilyHomologous superfamily
IPR037120 Haem peroxidase domain superfamily, animal typeFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
274500 OMIMThyroid dyshormonogenesis 2A (TDH2A)A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00389 CarbimazoleDrugbanksmall molecule
DB00509 DextrothyroxineDrugbanksmall molecule
DB00550 PropylthiouracilDrugbanksmall molecule
DB00763 MethimazoleDrugbanksmall molecule
DB05382 IodineDrugbanksmall molecule
DB08604 TriclosanDrugbanksmall molecule
DB11085 ResorcinolDrugbanksmall molecule
DB11496 2-mercaptobenzothiazoleDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PERT_HUMANTXD11_HUMANHPRD15561711 details
PERT_HUMANDUOX1_HUMANHPRD15561711 details