Entity Details

Primary name PROF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07737
EntryNamePROF1_HUMAN
FullNameProfilin-1
TaxID9606
Evidenceevidence at protein level
Length140
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesPFN1

GO terms

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GOName
GO:0000774 adenyl-nucleotide exchange factor activity
GO:0001784 phosphotyrosine residue binding
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0010634 positive regulation of epithelial cell migration
GO:0016020 membrane
GO:0030036 actin cytoskeleton organization
GO:0030833 regulation of actin filament polymerization
GO:0030837 negative regulation of actin filament polymerization
GO:0030838 positive regulation of actin filament polymerization
GO:0032232 negative regulation of actin filament bundle assembly
GO:0032233 positive regulation of actin filament bundle assembly
GO:0032781 positive regulation of ATPase activity
GO:0045296 cadherin binding
GO:0050821 protein stabilization
GO:0051497 negative regulation of stress fiber assembly
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0070062 extracellular exosome
GO:0070064 proline-rich region binding
GO:0072562 blood microparticle
GO:1900029 positive regulation of ruffle assembly

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR005454 Profilin1/2/3, vertebrateFamilyFamily
IPR005455 ProfilinFamilyFamily
IPR027310 Profilin conserved siteSiteConserved site
IPR029892 Profilin-1FamilyFamily
IPR036140 Profilin superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614808 OMIMAmyotrophic lateral sclerosis 18 (ALS18)A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB07908 7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARINDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
PROF1_HUMANDPYL1_HUMANBioGRID, HPRD, IntAct16169070 details
PROF1_HUMANU119A_HUMANBioGRID, HPRD, IntAct16169070 details
PROF1_HUMANERG28_HUMANBioGRID, HPRD, IntAct16169070 details
PROF1_HUMANDLG5_HUMANBioGRID, HPRD, IntAct16169070 34079125 details
PROF1_HUMANTLE1_HUMANBioGRID, HPRD, IntAct16169070 details
PROF1_HUMANACTB_HUMANBioGRID, DIP, HPRD, IntAct10411937 19000816 19338310 details
PROF1_HUMANRAD51_HUMANBioGRID, IntAct19338310 details
PROF1_HUMANWASF1_HUMANBioGRID, HPRD, mbinfo9843499 details
PROF1_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
PROF1_HUMANZNF16_HUMANUniProt21874239 details
PROF1_HUMANESR1_HUMANBioGRID, IntAct23576398 details
PROF1_HUMANVASP_HUMANBioGRID, HPRD, IntAct10882740 32814053 34079125 details
PROF1_HUMANAFAD_HUMANBioGRID10922060 details
PROF1_HUMANLRIF1_HUMANBioGRID, HPRD16169070 details
PROF1_HUMANRHOQ_HUMANBioGRID, HPRD10445846 details
PROF1_HUMANVIPR1_HUMANBioGRID10867004 details
PROF1_HUMANWASL_HUMANBioGRID, HPRD10867004 9822597 details
PROF1_HUMANFMNL1_HUMANBioGRID, HPRD10958683 details
PROF1_HUMANENAH_HUMANBioGRID, HPRD34079125 9473484 details
PROF1_HUMANGEPH_HUMANBioGRID, HPRD34079125 9473484 details
PROF1_HUMANNCK1_HUMANBioGRID9694849 details
PROF1_HUMAN1433T_HUMANBioGRID15161933 details
PROF1_HUMANCHIP_HUMANBioGRID24661873 details
PROF1_HUMANTRI15_HUMANBioGRID25450970 details
PROF1_HUMANTRAF6_HUMANBioGRID28024152 details
PROF1_HUMANSHPS1_HUMANBioGRID19299420 details
PROF1_HUMANAB1IP_HUMANHPRD15469846 details
PROF1_HUMANMYPOP_HUMANHPRD15615774 details
PROF1_HUMANRIF1_HUMANIntAct16169070 details
PROF1_HUMAN1433Z_HUMANMINT15161933 details
PROF1_HUMANXPO6_HUMANBioGRID, HPRD14592989 details
PROF1_HUMANITA4_HUMANBioGRID22623428 details
PROF1_HUMANPTEN_HUMANBioGRID26787927 details
PROF1_HUMANATG5_HUMANBioGRID33024031 details
PROF1_HUMANP85A_HUMANHPRD9801792 details
PROF1_HUMANDYN2_HUMANHPRD12419186 details
PROF1_HUMANWIPF2_HUMANHPRD12213210 details
PROF1_HUMANCMA1_HUMANHPRD11751973 details
PROF1_HUMANACTS_HUMANHPRD8413665 details
PROF1_HUMANDREB_HUMANHPRD9473484 details