Entity Details

Primary name ERCC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07992
EntryNameERCC1_HUMAN
FullNameDNA excision repair protein ERCC-1
TaxID9606
Evidenceevidence at protein level
Length297
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesERCC1

GO terms

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GOName
GO:0000109 nucleotide-excision repair complex
GO:0000110 nucleotide-excision repair factor 1 complex
GO:0000710 meiotic mismatch repair
GO:0000720 pyrimidine dimer repair by nucleotide-excision repair
GO:0000781 chromosome, telomeric region
GO:0001094 TFIID-class transcription factor complex binding
GO:0003684 damaged DNA binding
GO:0003697 single-stranded DNA binding
GO:0004519 endonuclease activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006293 nucleotide-excision repair, preincision complex stabilization
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0006312 mitotic recombination
GO:0006949 syncytium formation
GO:0006979 response to oxidative stress
GO:0007283 spermatogenesis
GO:0007584 response to nutrient
GO:0008022 protein C-terminus binding
GO:0008283 cell population proliferation
GO:0008584 male gonad development
GO:0009650 UV protection
GO:0009744 response to sucrose
GO:0010165 response to X-ray
GO:0010259 multicellular organism aging
GO:0019904 protein domain specific binding
GO:0032205 negative regulation of telomere maintenance
GO:0033683 nucleotide-excision repair, DNA incision
GO:0035166 post-embryonic hemopoiesis
GO:0035264 multicellular organism growth
GO:0035902 response to immobilization stress
GO:0036297 interstrand cross-link repair
GO:0045190 isotype switching
GO:0046686 response to cadmium ion
GO:0048477 oogenesis
GO:0048568 embryonic organ development
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0061819 telomeric DNA-containing double minutes formation
GO:0070522 ERCC4-ERCC1 complex
GO:0070911 global genome nucleotide-excision repair
GO:0070914 UV-damage excision repair
GO:0090399 replicative senescence
GO:0090656 t-circle formation
GO:1904431 positive regulation of t-circle formation
GO:1905765 negative regulation of protection from non-homologous end joining at telomere
GO:1990841 promoter-specific chromatin binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR004579 ERCC1/RAD10/SWI10 familyFamilyFamily
IPR010994 RuvA domain 2-likeFamilyHomologous superfamily
IPR011335 Restriction endonuclease type II-likeFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
610758 OMIMCerebro-oculo-facio-skeletal syndrome 4 (COFS4)A disorder of prenatal onset characterized by microcephaly, congenital cataracts, facial dysmorphism, neurogenic arthrogryposis, growth failure and severe psychomotor retardation. COFS is considered to be part of the nucleotide-excision repair disorders spectrum that include also xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome. The disease is caused by variants affecting the gene represented in this entry.

Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
ERCC1_HUMANUBL7_HUMANBioGRID, HPRD, IntAct16189514 25416956 25910212 details
ERCC1_HUMANXPA_HUMANBioGRID, DIP, HPRD, IntAct11058119 16491090 17948053 18597777 19056823 24036546 25416956 26186194 28514442 32296183 7598728 8197174 9013642 9653453 details
ERCC1_HUMANSLX4_HUMANBioGRID, IntAct19595721 19596235 19596236 21240275 22902628 23033263 23093618 23623386 25538220 26186194 28514442 31495888 32398829 details
ERCC1_HUMANSLX1_HUMANBioGRID, IntAct19595721 19596235 28514442 details
ERCC1_HUMANMKRN3_HUMANBioGRID, IntAct25416956 details
ERCC1_HUMANUSBP1_HUMANBioGRID, IntAct25416956 details
ERCC1_HUMANTRM2_HUMANBioGRID, IntAct25416956 details
ERCC1_HUMANVP37B_HUMANBioGRID, IntAct25416956 31515488 details
ERCC1_HUMANXPF_HUMANBioGRID, DIP, HPRD, IntAct10413517 11160918 14706347 14734547 15932882 16076955 16338413 17289582 17912758 19940136 21466675 21875596 22353549 22939629 23580445 24036546 24780295 25538220 25956741 26085086 26186194 26344197 26453996 28514442 31495888 8197175 9013642 9722633 details
ERCC1_HUMANDRC4_HUMANBioGRID, IntAct32296183 details
ERCC1_HUMANACM5_HUMANBioGRID, MINT28298427 details
ERCC1_HUMANFANCG_HUMANBioGRID20518486 details
ERCC1_HUMANUHRF1_HUMANBioGRID25818288 details
ERCC1_HUMANA4_HUMANBioGRID21244100 details
ERCC1_HUMANUBP45_HUMANBioGRID25538220 30258100 details
ERCC1_HUMANRFA1_HUMANBioGRID24036546 details
ERCC1_HUMANRFA2_HUMANBioGRID24036546 details
ERCC1_HUMANRFA3_HUMANBioGRID24036546 details
ERCC1_HUMANKIF11_HUMANBioGRID22353549 details
ERCC1_HUMANRAD52_HUMANBioGRID14734547 details
ERCC1_HUMANEGFR_HUMANBioGRID, IntAct24780295 details
ERCC1_HUMANMUS81_HUMANBioGRID, IntAct25538220 28514442 details
ERCC1_HUMANSLX4I_HUMANBioGRID, IntAct26186194 28514442 31495888 details
ERCC1_HUMANCASS4_HUMANIntAct31413325 details
ERCC1_HUMANTF2H1_HUMANBioGRID11259578 details
ERCC1_HUMANTAF6_HUMANBioGRID22323595 details
ERCC1_HUMANTAF7_HUMANBioGRID22323595 details
ERCC1_HUMANTAF10_HUMANBioGRID22323595 details
ERCC1_HUMANTAF12_HUMANBioGRID22323595 details
ERCC1_HUMANTBP_HUMANBioGRID22323595 details
ERCC1_HUMANRPB1_HUMANBioGRID16916636 details
ERCC1_HUMANMSH2_HUMANBioGRID14706347 details
ERCC1_HUMANSPTA1_HUMANBioGRID16889989 details
ERCC1_HUMANERCC1_HUMANBioGRID28903417 details
ERCC1_HUMANMD2L1_HUMANBioGRID18597777 details
ERCC1_HUMANDCAF7_HUMANBioGRID31493872 details