Entity Details

Primary name TNR16_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08138
EntryNameTNR16_HUMAN
FullNameTumor necrosis factor receptor superfamily member 16
TaxID9606
Evidenceevidence at protein level
Length427
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesNGFR

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001678 cellular glucose homeostasis
GO:0004888 transmembrane signaling receptor activity
GO:0005035 death receptor activity
GO:0005516 calmodulin binding
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0006886 intracellular protein transport
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007266 Rho protein signal transduction
GO:0007411 axon guidance
GO:0007417 central nervous system development
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0015026 coreceptor activity
GO:0016021 integral component of membrane
GO:0016048 detection of temperature stimulus
GO:0021675 nerve development
GO:0030426 growth cone
GO:0031069 hair follicle morphogenesis
GO:0031267 small GTPase binding
GO:0031293 membrane protein intracellular domain proteolysis
GO:0031625 ubiquitin protein ligase binding
GO:0032922 circadian regulation of gene expression
GO:0035907 dorsal aorta development
GO:0038023 signaling receptor activity
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042488 positive regulation of odontogenesis of dentin-containing tooth
GO:0042593 glucose homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043121 neurotrophin binding
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043197 dendritic spine
GO:0043204 perikaryon
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048146 positive regulation of fibroblast proliferation
GO:0048406 nerve growth factor binding
GO:0050771 negative regulation of axonogenesis
GO:0050772 positive regulation of axonogenesis
GO:0051402 neuron apoptotic process
GO:0051799 negative regulation of hair follicle development
GO:1900182 positive regulation of protein localization to nucleus
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1904646 cellular response to amyloid-beta
GO:2001235 positive regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Perikaryon

Domains

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DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR001368 TNFR/NGFR cysteine-rich regionDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR022325 Tumour necrosis factor receptor 16FamilyFamily
IPR034046 Tumor necrosis factor receptor 16, N-terminalDomainDomain
IPR041448 Tumor necrosis factor receptor member 16, transmembrane domainDomainDomain

Diseases

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Interactions

70 interactions

InteractorPartnerSourcesPublicationsLink
TNR16_HUMANBEX3_HUMANHPRD, IntAct10764727 17355907 details
TNR16_HUMANSALL2_HUMANBioGRID, MINT19131967 details
TNR16_HUMANTNR16_HUMANBioGRID, IntAct11756426 14960584 27084575 details
TNR16_HUMANCD80_HUMANBioGRID, IntAct21982860 details
TNR16_HUMANANXA7_HUMANBioGRID, MINT21900206 details
TNR16_HUMANCDN1A_HUMANBioGRID, MINT21900206 details
TNR16_HUMANH2AX_HUMANBioGRID, MINT21900206 details
TNR16_HUMANRCC1_HUMANBioGRID, MINT21900206 details
TNR16_HUMANRPN2_HUMANBioGRID, MINT21900206 details
TNR16_HUMANSMN_HUMANBioGRID, MINT21900206 details
TNR16_HUMANSTMN2_HUMANBioGRID, MINT21900206 details
TNR16_HUMANKITH_HUMANBioGRID, MINT21900206 details
TNR16_HUMANTTHY_HUMANBioGRID, MINT21900206 details
TNR16_HUMANUFD1_HUMANBioGRID, MINT21900206 details
TNR16_HUMANNGF_HUMANbhf-ucl, BioGRID, HPRD11729324 14985763 details
TNR16_HUMANSORC2_HUMANbhf-ucl24908487 details
TNR16_HUMANA4_HUMANBioGRID, DIP19225519 19334058 19710315 details
TNR16_HUMANTNR21_HUMANUniProt23559013 details
TNR16_HUMANCHIP_HUMANIntAct32814053 details
TNR16_HUMANSPRE1_HUMANIntAct32814053 details
TNR16_HUMANKAPCB_HUMANBioGRID, HPRD12682012 details
TNR16_HUMANNECD_HUMANBioGRID, HPRD12414813 12716928 14593116 details
TNR16_HUMANNSE3_HUMANBioGRID14593116 details
TNR16_HUMANFSCN1_HUMANBioGRID, HPRD12789270 details
TNR16_HUMANMAGD1_HUMANBioGRID, HPRD10985348 12716928 21151024 details
TNR16_HUMANMAGH1_HUMANBioGRID, HPRD12414813 21418516 details
TNR16_HUMANCAV1_HUMANBioGRID, HPRD9867838 details
TNR16_HUMANTRAF4_HUMANBioGRID, HPRD10514511 9626059 details
TNR16_HUMANTRAF6_HUMANBioGRID, HPRD10514511 14960584 23017601 9915784 details
TNR16_HUMANTRAF2_HUMANBioGRID, HPRD10514511 details
TNR16_HUMANTRI37_HUMANBioGRID11279055 details
TNR16_HUMANTCF19_HUMANBioGRID10485890 details
TNR16_HUMANBFAR_HUMANBioGRID22566094 details
TNR16_HUMANMDM2_HUMANBioGRID27282385 details
TNR16_HUMANP53_HUMANBioGRID27282385 details
TNR16_HUMANBNI3L_HUMANBioGRID27726026 details
TNR16_HUMANPDLI1_HUMANBioGRID26119933 details
TNR16_HUMANKDIS_HUMANBioGRID, HPRD11150334 15378608 details
TNR16_HUMANEGR1_HUMANBioGRID18378044 details
TNR16_HUMANSORT_HUMANbhf-ucl, BioGRID, HPRD14985763 20159974 21261755 details
TNR16_HUMANRTN4R_HUMANBioGRID, HPRD, UniProt12422217 14966521 25666623 details
TNR16_HUMANLIGO1_HUMANBioGRID, HPRD, UniProt14966521 20659559 25666623 details
TNR16_HUMANTRADD_HUMANBioGRID, HPRD12604596 details
TNR16_HUMANTRAF1_HUMANBioGRID10514511 details
TNR16_HUMANTRAF3_HUMANBioGRID10514511 details
TNR16_HUMANTRAF5_HUMANBioGRID10514511 details
TNR16_HUMANSHC1_HUMANBioGRID, HPRD7541035 details
TNR16_HUMANSQSTM_HUMANBioGRID23017601 details
TNR16_HUMANIKKB_HUMANBioGRID23017601 details
TNR16_HUMANNTRK1_HUMANBioGRID, HPRD24333329 25708205 9927421 details
TNR16_HUMANNTRK2_HUMANBioGRID, HPRD28821608 9927421 details
TNR16_HUMANSIAH1_HUMANBioGRID30081046 details
TNR16_HUMANITA9_HUMANBioGRID25748048 details
TNR16_HUMANBEX1_HUMANBioGRID, HPRD16498402 details
TNR16_HUMANRIPK2_HUMANBioGRID, HPRD11487608 16498402 details
TNR16_HUMANNTF3_HUMANBioGRID21261755 details
TNR16_HUMANHIPK2_HUMANBioGRID18378044 details
TNR16_HUMANPO4F2_HUMANBioGRID18378044 details
TNR16_HUMANBACE1_HUMANBioGRID28869759 details
TNR16_HUMANGRB2_HUMANHPRD9368064 details
TNR16_HUMANPTN13_HUMANHPRD10544233 details
TNR16_HUMANMK01_HUMANHPRD8407983 details
TNR16_HUMANMK03_HUMANHPRD8407983 details
TNR16_HUMANZN274_HUMANHPRD10545116 details
TNR16_HUMANIKBB_HUMANHPRD12034707 details
TNR16_HUMANIL2_HUMANHPRD1316918 details
TNR16_HUMANMAG_HUMANHPRD12011108 details
TNR16_HUMANNTF4_HUMANHPRD7541633 details
TNR16_HUMANNTRK3_HUMANHPRD9927421 details
TNR16_HUMANTRA2B_HUMANHPRD12604596 details