Entity Details

Primary name BGLR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08236
EntryNameBGLR_HUMAN
FullNameBeta-glucuronidase
TaxID9606
Evidenceevidence at protein level
Length651
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesGUSB

GO terms

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GOName
GO:0004566 beta-glucuronidase activity
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005975 carbohydrate metabolic process
GO:0006027 glycosaminoglycan catabolic process
GO:0016020 membrane
GO:0019391 glucuronoside catabolic process
GO:0019904 protein domain specific binding
GO:0030214 hyaluronan catabolic process
GO:0030246 carbohydrate binding
GO:0035578 azurophil granule lumen
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0043312 neutrophil degranulation
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Lysosome

Domains

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DomainNameCategoryType
IPR006101 Glycoside hydrolase, family 2FamilyFamily
IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwichDomainDomain
IPR006103 Glycoside hydrolase family 2, catalytic domainDomainDomain
IPR006104 Glycosyl hydrolases family 2, sugar binding domainDomainDomain
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017853 Glycoside hydrolase superfamilyFamilyHomologous superfamily
IPR023230 Glycoside hydrolase, family 2, conserved siteSiteConserved site
IPR023232 Glycoside hydrolase, family 2, active siteSiteActive site
IPR036156 Beta-Galactosidase/glucuronidase domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
253220 OMIMMucopolysaccharidosis 7 (MPS7)An autosomal recessive lysosomal storage disease characterized by inability to degrade glucuronic acid-containing glycosaminoglycans. The phenotype is highly variable, ranging from severe lethal hydrops fetalis to mild forms with survival into adulthood. Most patients with the intermediate phenotype show hepatomegaly, skeletal anomalies, coarse facies, and variable degrees of mental impairment. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB09301 Chondroitin sulfateDrugbanksmall molecule
DB09340 Tyropanoic acidSwissprotsmall molecule
DB11793 NiraparibDrugbanksmall molecule

Interactions

4 interactions