Entity Details

Primary name ASNS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08243
EntryNameASNS_HUMAN
FullNameAsparagine synthetase [glutamine-hydrolyzing]
TaxID9606
Evidenceevidence at protein level
Length561
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesASNS

GO terms

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GOName
GO:0001889 liver development
GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006529 asparagine biosynthetic process
GO:0006541 glutamine metabolic process
GO:0009066 aspartate family amino acid metabolic process
GO:0009416 response to light stimulus
GO:0009612 response to mechanical stimulus
GO:0009636 response to toxic substance
GO:0031427 response to methotrexate
GO:0032354 response to follicle-stimulating hormone
GO:0032870 cellular response to hormone stimulus
GO:0042149 cellular response to glucose starvation
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043200 response to amino acid
GO:0045931 positive regulation of mitotic cell cycle
GO:0070981 L-asparagine biosynthetic process

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001962 Asparagine synthaseDomainDomain
IPR006426 Asparagine synthase, glutamine-hydrolyzingFamilyFamily
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily
IPR017932 Glutamine amidotransferase type 2 domainDomainDomain
IPR029055 Nucleophile aminohydrolases, N-terminalFamilyHomologous superfamily
IPR033738 Asparagine synthase, N-terminal domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00128 Aspartic acidDrugbanksmall molecule
DB00130 L-GlutamineDrugbanksmall molecule
DB00142 Glutamic acidDrugbanksmall molecule
DB00171 ATPDrugbanksmall molecule
DB00174 AsparagineDrugbanksmall molecule