Entity Details

Primary name PTPRC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08575
EntryNamePTPRC_HUMAN
FullNameReceptor-type tyrosine-protein phosphatase C
TaxID9606
Evidenceevidence at protein level
Length1306
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesPTPRC

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001779 natural killer cell differentiation
GO:0001915 negative regulation of T cell mediated cytotoxicity
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002639 positive regulation of immunoglobulin production
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005102 signaling receptor binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006469 negative regulation of protein kinase activity
GO:0006470 protein dephosphorylation
GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007159 leukocyte cell-cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0008201 heparin binding
GO:0009897 external side of plasma membrane
GO:0009898 cytoplasmic side of plasma membrane
GO:0009986 cell surface
GO:0010332 response to gamma radiation
GO:0010468 regulation of gene expression
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016032 viral process
GO:0016311 dephosphorylation
GO:0019901 protein kinase binding
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030506 ankyrin binding
GO:0030507 spectrin binding
GO:0030667 secretory granule membrane
GO:0030890 positive regulation of B cell proliferation
GO:0031668 cellular response to extracellular stimulus
GO:0031953 negative regulation of protein autophosphorylation
GO:0032059 bleb
GO:0032677 regulation of interleukin-8 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034113 heterotypic cell-cell adhesion
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0042098 T cell proliferation
GO:0042100 B cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0043312 neutrophil degranulation
GO:0043395 heparan sulfate proteoglycan binding
GO:0043410 positive regulation of MAPK cascade
GO:0044770 cell cycle phase transition
GO:0044855 plasma membrane raft distribution
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0045121 membrane raft
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0048539 bone marrow development
GO:0048864 stem cell development
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050764 regulation of phagocytosis
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0050857 positive regulation of antigen receptor-mediated signaling pathway
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051607 defense response to virus
GO:0051726 regulation of cell cycle
GO:0061097 regulation of protein tyrosine kinase activity
GO:0061099 negative regulation of protein tyrosine kinase activity
GO:0070062 extracellular exosome
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0098857 membrane microdomain
GO:1903615 positive regulation of protein tyrosine phosphatase activity
GO:1903979 negative regulation of microglial cell activation
GO:1904155 DN2 thymocyte differentiation
GO:1905451 positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
GO:2000473 positive regulation of hematopoietic stem cell migration
GO:2000648 positive regulation of stem cell proliferation
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Membrane raft

Domains

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DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR016335 Receptor-type tyrosine-protein phosphatase CFamilyFamily
IPR024739 Protein tyrosine phosphatase, receptor type, N-terminalDomainDomain
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
608971 OMIMSevere combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID)A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. The disease is caused by variants affecting the gene represented in this entry.
126200 OMIMMultiple sclerosis (MS)A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Disease susceptibility may be associated with variants affecting the gene represented in this entry.

Interactions

78 interactions

InteractorPartnerSourcesPublicationsLink
PTPRC_HUMANLCK_HUMANBioGRID, DIP, HPRD, IntAct, MINT10330160 10369126 11369760 12589038 14625311 15085197 19167335 24463463 7507203 8473339 8576115 8663450 9533446 9973453 details
PTPRC_HUMANPTPRC_HUMANBioGRID, HPRD, MINT10683443 15978577 details
PTPRC_HUMANCADH2_HUMANIntAct19167335 details
PTPRC_HUMANTEC_HUMANIntAct19167335 details
PTPRC_HUMANERBB2_HUMANIntAct19167335 details
PTPRC_HUMANPGFRB_HUMANIntAct19167335 details
PTPRC_HUMANMET_HUMANIntAct19167335 details
PTPRC_HUMANPAXI_HUMANIntAct19167335 details
PTPRC_HUMANCTNB1_HUMANIntAct, MINT12370829 19167335 details
PTPRC_HUMANINSR_HUMANHPRD, IntAct1373652 19167335 details
PTPRC_HUMANTIE1_HUMANIntAct19167335 details
PTPRC_HUMANCSK_HUMANIntAct, MINT19167335 7507203 details
PTPRC_HUMANGAB1_HUMANIntAct19167335 details
PTPRC_HUMANNMDE2_HUMANIntAct19167335 details
PTPRC_HUMANNTRK1_HUMANIntAct19167335 details
PTPRC_HUMANPDPK1_HUMANIntAct19167335 details
PTPRC_HUMANNSF_HUMANIntAct19167335 details
PTPRC_HUMANGHR_HUMANIntAct19167335 details
PTPRC_HUMANEPOR_HUMANIntAct19167335 details
PTPRC_HUMANEGFR_HUMANIntAct19167335 31980649 details
PTPRC_HUMANMK03_HUMANIntAct19167335 details
PTPRC_HUMANTIE2_HUMANIntAct19167335 details
PTPRC_HUMANWASP_HUMANIntAct19167335 details
PTPRC_HUMANACK1_HUMANIntAct19167335 details
PTPRC_HUMANCBL_HUMANIntAct19167335 details
PTPRC_HUMANLEPR_HUMANIntAct19167335 details
PTPRC_HUMANPKP4_HUMANIntAct19167335 details
PTPRC_HUMANITAL_HUMANBioGRID, HPRD, MINT15946252 details
PTPRC_HUMANLEG1_HUMANBioGRID, HPRD, MINT10369126 10490978 details
PTPRC_HUMANUHRF2_HUMANBioGRID, UniProt21952639 details
PTPRC_HUMANSKAP1_HUMANBioGRID, HPRD11909961 details
PTPRC_HUMANGANAB_HUMANBioGRID, HPRD10921916 11564800 9148925 details
PTPRC_HUMANPTCA_HUMANBioGRID, HPRD7499298 8537410 details
PTPRC_HUMANCD2_HUMANBioGRID, HPRD1970422 1976695 details
PTPRC_HUMANCD8A_HUMANBioGRID, HPRD1834739 details
PTPRC_HUMANCD4_HUMANBioGRID, HPRD1834739 details
PTPRC_HUMANCD3Z_HUMANBioGRID, HPRD7526385 details
PTPRC_HUMANLYN_HUMANBioGRID, HPRD10415030 12393728 7516335 details
PTPRC_HUMANRNF11_HUMANBioGRID, HPRD15231748 details
PTPRC_HUMANFYN_HUMANBioGRID, HPRD12589038 14625311 8980254 9368621 9535845 details
PTPRC_HUMANSRC_HUMANBioGRID14625311 details
PTPRC_HUMANMK01_HUMANBioGRID10415025 details
PTPRC_HUMANSEM4D_HUMANBioGRID, HPRD, MINT10648410 11254687 8955171 details
PTPRC_HUMANCD22_HUMANBioGRID, HPRD, MINT10228003 10648410 7537381 details
PTPRC_HUMANCD244_HUMANIntAct23346089 details
PTPRC_HUMANCXCR4_HUMANHPRD, MINT12519755 21912642 details
PTPRC_HUMANPAEP_HUMANBioGRID, HPRD12556471 details
PTPRC_HUMANGLU2B_HUMANBioGRID, HPRD9148925 details
PTPRC_HUMANPLK3_HUMANBioGRID11551930 details
PTPRC_HUMANSLAF1_HUMANBioGRID10229804 details
PTPRC_HUMANCD44_HUMANBioGRID9573028 details
PTPRC_HUMANCD79A_HUMANBioGRID7516335 details
PTPRC_HUMANCD79B_HUMANBioGRID7516335 details
PTPRC_HUMANCD1D_HUMANBioGRID, HPRD10473580 details
PTPRC_HUMANU2AF2_HUMANBioGRID26641092 details
PTPRC_HUMANMK14_HUMANBioGRID10415025 details
PTPRC_HUMANGRB2_HUMANHPRD8570203 details
PTPRC_HUMANCSK21_HUMANHPRD10066810 details
PTPRC_HUMANCSK22_HUMANHPRD10066810 details
PTPRC_HUMANINAR1_HUMANHPRD9403695 details
PTPRC_HUMANEZRI_HUMANHPRD12560083 details
PTPRC_HUMANRASA1_HUMANHPRD8570203 details
PTPRC_HUMANFCG3A_HUMANHPRD8157290 details
PTPRC_HUMANIRS1_HUMANHPRD8557683 details
PTPRC_HUMANJAK1_HUMANHPRD11201744 details
PTPRC_HUMANJAK2_HUMANHPRD11201744 details
PTPRC_HUMANMBL2_HUMANHPRD11564800 details
PTPRC_HUMANPTN6_HUMANHPRD10228003 9368621 details
PTPRC_HUMANTYK2_HUMANHPRD11201744 details
PTPRC_HUMANZAP70_HUMANHPRD7737297 details
PTPRC_HUMANCD28_HUMANHPRD1355979 details
PTPRC_HUMANDPP4_HUMANHPRD1680916 details
PTPRC_HUMANJAK3_HUMANHPRD11994288 details
PTPRC_HUMANLCP2_HUMANHPRD8703037 details
PTPRC_HUMANLIPB2_HUMANHPRD9624153 details
PTPRC_HUMANLSM1_HUMANHPRD8980254 details
PTPRC_HUMANAN32A_HUMANHPRD1655467 details
PTPRC_HUMANLIPA1_HUMANHPRD9624153 details