Entity Details

Primary name ANXA5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08758
EntryNameANXA5_HUMAN
FullNameAnnexin A5
TaxID9606
Evidenceevidence at protein level
Length320
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GenesANXA5

GO terms

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GOName
GO:0002576 platelet degranulation
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005543 phospholipid binding
GO:0005544 calcium-dependent phospholipid binding
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0016020 membrane
GO:0043066 negative regulation of apoptotic process
GO:0050819 negative regulation of coagulation
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001464 AnnexinFamilyFamily
IPR002392 Annexin A5FamilyFamily
IPR018252 Annexin repeat, conserved siteSiteConserved site
IPR018502 Annexin repeatRepeatRepeat
IPR037104 Annexin superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614391 OMIMPregnancy loss, recurrent, 3 (RPRGL3)A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00591 Fluocinolone acetonideDrugbanksmall molecule
DB02497 L-Alpha-GlycerophosphorylserineDrugbanksmall molecule
DB02846 L-thioprolineDrugbanksmall molecule
DB02929 K201 free baseDrugbanksmall molecule
DB03484 sn-glycero-3-phosphoethanolamineDrugbanksmall molecule
DB03935 1,4-Dideoxy-O2-Sulfo-Glucuronic AcidDrugbanksmall molecule
DB03959 N,O6-Disulfo-GlucosamineDrugbanksmall molecule
DB03981 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic AcidDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule

Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
ANXA5_HUMANFDFT_HUMANBioGRID, HPRD, IntAct16169070 details
ANXA5_HUMANIF4G1_HUMANHPRD, IntAct16169070 details
ANXA5_HUMANSPT4H_HUMANHPRD, IntAct16169070 details
ANXA5_HUMANLAMC3_HUMANBioGRID, IntAct21988832 details
ANXA5_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
ANXA5_HUMANTERF2_HUMANbhf-ucl, BioGRID21044950 details
ANXA5_HUMANTE2IP_HUMANbhf-ucl, BioGRID21044950 details
ANXA5_HUMANTINF2_HUMANbhf-ucl, BioGRID21044950 details
ANXA5_HUMANGSC2_HUMANBioGRID, IntAct32296183 details
ANXA5_HUMANHSPB1_HUMANIntAct32814053 details
ANXA5_HUMANWFS1_HUMANIntAct32814053 details
ANXA5_HUMANOPTN_HUMANIntAct32814053 details
ANXA5_HUMANVGFR2_HUMANBioGRID, HPRD10329451 details
ANXA5_HUMANITB5_HUMANBioGRID, HPRD12769841 details
ANXA5_HUMANCO2A1_HUMANBioGRID, HPRD1397263 details
ANXA5_HUMANCOAA1_HUMANBioGRID, HPRD1397263 details
ANXA5_HUMANA4_HUMANBioGRID21832049 details
ANXA5_HUMANINGR2_HUMANHPRD16670301 details
ANXA5_HUMANEED_HUMANHPRD9584197 details
ANXA5_HUMANIF2P_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANCPNE3_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANHPRT_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANPA2G4_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANSIAS_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANIPYR_HUMANBioGRID, IntAct27173435 31536960 unassigned1312 details
ANXA5_HUMANUBE2N_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANRM12_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANIDHP_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANRU2B_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANDNJC8_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANCISY_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANZN207_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANG6PI_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANPYGL_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANPLST_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANPDIA3_HUMANBioGRID, IntAct24981860 26344197 27173435 unassigned1312 details
ANXA5_HUMANSF3A3_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANTRAP1_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANSF3A1_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANCPSF6_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANSND1_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANCRNN_HUMANBioGRID, IntAct27173435 unassigned1312 details
ANXA5_HUMANANXA1_HUMANBioGRID12689596 details
ANXA5_HUMANU2AF2_HUMANBioGRID26641092 details
ANXA5_HUMANFBLN3_HUMANBioGRID27777122 details
ANXA5_HUMANACTG_HUMANHPRD10903505 details