Entity Details

Primary name THIK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09110
EntryNameTHIK_HUMAN
FullName3-ketoacyl-CoA thiolase, peroxisomal
TaxID9606
Evidenceevidence at protein level
Length424
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesACAA1

GO terms

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GOName
GO:0000038 very long-chain fatty acid metabolic process
GO:0003985 acetyl-CoA C-acetyltransferase activity
GO:0003988 acetyl-CoA C-acyltransferase activity
GO:0005576 extracellular region
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0006635 fatty acid beta-oxidation
GO:0008104 protein localization
GO:0008206 bile acid metabolic process
GO:0008775 acetate CoA-transferase activity
GO:0010124 phenylacetate catabolic process
GO:0016020 membrane
GO:0016401 palmitoyl-CoA oxidase activity
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase
GO:0035580 specific granule lumen
GO:0036109 alpha-linolenic acid metabolic process
GO:0043312 neutrophil degranulation
GO:0050633 acetyl-CoA C-myristoyltransferase activity

Subcellular Location

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Subcellular Location
Peroxisome

Domains

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DomainNameCategoryType
IPR002155 ThiolaseFamilyFamily
IPR016039 Thiolase-likeFamilyHomologous superfamily
IPR020610 Thiolase, active siteSiteActive site
IPR020613 Thiolase, conserved siteSiteConserved site
IPR020615 Thiolase, acyl-enzyme intermediate active siteSiteActive site
IPR020616 Thiolase, N-terminalDomainDomain
IPR020617 Thiolase, C-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB09069 TrimetazidineDrugbanksmall molecule

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
THIK_HUMANTXD11_HUMANBioGRID, IntAct21988832 details
THIK_HUMANFEM1A_HUMANBioGRID, IntAct32296183 details
THIK_HUMANTFCP2_HUMANBioGRID, IntAct32296183 details
THIK_HUMANHAT1_HUMANBioGRID9427644 details