Entity Details

Primary name F16P1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09467
EntryNameF16P1_HUMAN
FullNameFructose-1,6-bisphosphatase 1
TaxID9606
Evidenceevidence at protein level
Length338
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesFBP1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005986 sucrose biosynthetic process
GO:0006000 fructose metabolic process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006094 gluconeogenesis
GO:0006111 regulation of gluconeogenesis
GO:0016208 AMP binding
GO:0016311 dephosphorylation
GO:0030308 negative regulation of cell growth
GO:0030388 fructose 1,6-bisphosphate metabolic process
GO:0035690 cellular response to drug
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042802 identical protein binding
GO:0045820 negative regulation of glycolytic process
GO:0046580 negative regulation of Ras protein signal transduction
GO:0046872 metal ion binding
GO:0048029 monosaccharide binding
GO:0070062 extracellular exosome
GO:0071286 cellular response to magnesium ion

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000146 Fructose-1,6-bisphosphatase class 1FamilyFamily
IPR020548 Fructose-1,6-bisphosphatase, active siteSiteActive site
IPR028343 Fructose-1,6-bisphosphataseFamilyFamily
IPR033391 Fructose-1-6-bisphosphatase class I, N-terminalDomainDomain
IPR044015 Fructose-1-6-bisphosphatase class 1, C-terminalDomainDomain

Diseases

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Disease IDSourceNameDescription
229700 OMIMFructose-1,6-bisphosphatase deficiency (FBP1D)An autosomal recessive metabolic disorder characterized by impaired gluconeogenesis, and episodes of hypoglycemia and metabolic acidosis that can be lethal in newborn infants or young children. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00131 Adenosine phosphateDrugbanksmall molecule
DB02778 2,5-Anhydroglucitol-1,6-BiphosphateDrugbanksmall molecule
DB02848 {4-[3-(6,7-Diethoxy-Quinazolin-4-Ylamino)-Phenyl]-Thiazol-2-Yl}-MethanolDrugbanksmall molecule
DB04175 Mdl-29951Drugbanksmall molecule
DB04493 Fructose-6-phosphateDrugbanksmall molecule
DB05053 MB-07803Drugbanksmall molecule
DB05518 Managlinat dialanetilDrugbanksmall molecule
DB07270 N-[7-(3-AMINOPHENYL)-5-METHOXY-1,3-BENZOXAZOL-2-YL]-2,5-DICHLOROBENZENESULFONAMIDEDrugbanksmall molecule
DB07312 2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDEDrugbanksmall molecule
DB07321 2,5-DICHLORO-N-[5-METHOXY-7-(6-METHOXYPYRIDIN-3-YL)-1,3-BENZOXAZOL-2-YL]BENZENESULFONAMIDEDrugbanksmall molecule
DB08484 4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDEDrugbanksmall molecule

Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
F16P1_HUMANASCC2_HUMANBioGRID, HPRD, IntAct16169070 details
F16P1_HUMANF16P1_HUMANBioGRID, HPRD, IntAct, MINT16169070 16189514 21516116 2164670 25416956 25502805 25910212 31515488 32296183 details
F16P1_HUMANHSP7C_HUMANBioGRID, HPRD, IntAct16169070 32041737 details
F16P1_HUMANATPK_HUMANBioGRID, HPRD, IntAct16169070 details
F16P1_HUMANPCX4_HUMANBioGRID, HPRD, IntAct16189514 details
F16P1_HUMANFXR2_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
F16P1_HUMANRN183_HUMANBioGRID, HPRD, IntAct16189514 details
F16P1_HUMANLNX1_HUMANBioGRID, HPRD, IntAct16189514 details
F16P1_HUMANBIN1_HUMANBioGRID, HPRD, IntAct16275660 details
F16P1_HUMANNKG2C_HUMANBioGRID, IntAct21988832 details
F16P1_HUMANARLY_HUMANBioGRID, IntAct21988832 details
F16P1_HUMANB2CL1_HUMANBioGRID, MINT21900206 details
F16P1_HUMANKC1E_HUMANBioGRID, MINT21900206 details
F16P1_HUMANDC1I1_HUMANBioGRID, MINT21900206 details
F16P1_HUMANHDAC6_HUMANBioGRID, MINT21900206 details
F16P1_HUMANFAK1_HUMANBioGRID, MINT21900206 details
F16P1_HUMANAPC_HUMANBioGRID, MINT24412244 details
F16P1_HUMANAXIN2_HUMANBioGRID, MINT24412244 details
F16P1_HUMANBCL10_HUMANBioGRID, MINT24412244 details
F16P1_HUMANBMR1A_HUMANBioGRID, MINT24412244 details
F16P1_HUMANBRAF_HUMANBioGRID, MINT24412244 details
F16P1_HUMANBUB1_HUMANBioGRID, MINT24412244 details
F16P1_HUMANCTNA1_HUMANBioGRID, MINT24412244 details
F16P1_HUMANDCC_HUMANBioGRID, MINT24412244 details
F16P1_HUMANERBB2_HUMANBioGRID, MINT24412244 details
F16P1_HUMANFBXW7_HUMANBioGRID, MINT24412244 details
F16P1_HUMANFLCN_HUMANBioGRID, MINT24412244 details
F16P1_HUMANMLH3_HUMANBioGRID, MINT24412244 details
F16P1_HUMANMSH2_HUMANBioGRID, MINT24412244 details
F16P1_HUMANPTPRJ_HUMANBioGRID, MINT24412244 details
F16P1_HUMANRB_HUMANBioGRID, MINT24412244 details
F16P1_HUMANSTK11_HUMANBioGRID, MINT24412244 details
F16P1_HUMANTLR2_HUMANBioGRID, MINT24412244 details
F16P1_HUMANF16P2_HUMANBioGRID, IntAct25416956 25910212 26186194 28514442 31515488 32041737 32296183 details
F16P1_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
F16P1_HUMANPOTE1_HUMANbhf-ucl, BioGRID21044950 details
F16P1_HUMANHIF1A_HUMANDIP25043030 details
F16P1_HUMANEPAS1_HUMANDIP25043030 details
F16P1_HUMANBAAT_HUMANIntAct31515488 details
F16P1_HUMANHD_HUMANIntAct32814053 details
F16P1_HUMANPRKN_HUMANBioGRID21209200 details
F16P1_HUMANTIF1B_HUMANBioGRID28394358 30201002 details
F16P1_HUMANTF65_HUMANBioGRID32041737 32754266 details
F16P1_HUMANNOTC1_HUMANBioGRID32041737 details
F16P1_HUMANPIM2_HUMANBioGRID32754266 details
F16P1_HUMANACTN3_HUMANMINT12507293 details
F16P1_HUMANEZH2_HUMANBioGRID31948940 details
F16P1_HUMANACTN1_HUMANHPRD12507293 details