Entity Details

Primary name GRAB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10144
EntryNameGRAB_HUMAN
FullNameGranzyme B
TaxID9606
Evidenceevidence at protein level
Length247
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesGZMB

GO terms

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GOName
GO:0001772 immunological synapse
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0008236 serine-type peptidase activity
GO:0016020 membrane
GO:0017148 negative regulation of translation
GO:0019835 cytolysis
GO:0042267 natural killer cell mediated cytotoxicity
GO:0043231 intracellular membrane-bounded organelle
GO:0044194 cytolytic granule
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0070269 pyroptosis
GO:0140507 granzyme-mediated programmed cell death signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytolytic granule
Secreted

Domains

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DomainNameCategoryType
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
GRAB_HUMANSRGN_HUMANBioGRID, HPRD, IntAct10228010 11911826 12388539 details
GRAB_HUMANFINC_HUMANmatrixdb23228447 details
GRAB_HUMANSPB9_HUMANBioGRID, HPRD8910377 details
GRAB_HUMANUBE4A_HUMANBioGRID, HPRD11802788 details
GRAB_HUMANLMNA_HUMANBioGRID11331782 details
GRAB_HUMANPRKDC_HUMANBioGRID, HPRD8760815 9586635 details
GRAB_HUMANXRCC6_HUMANBioGRID8760815 details
GRAB_HUMANXRCC5_HUMANBioGRID8760815 details
GRAB_HUMANCASP3_HUMANBioGRID, HPRD17008916 17283187 9233763 9694885 details
GRAB_HUMANTEBP_HUMANBioGRID17283187 details
GRAB_HUMANBID_HUMANBioGRID, HPRD11085743 17283187 9727491 details
GRAB_HUMANCASP7_HUMANBioGRID, HPRD17283187 8631895 details
GRAB_HUMANCASP8_HUMANBioGRID17283187 details
GRAB_HUMANDFFA_HUMANBioGRID, HPRD11406587 17283187 details
GRAB_HUMANCD2AP_HUMANBioGRID17283187 details
GRAB_HUMANTBA1A_HUMANBioGRID17283187 details
GRAB_HUMANELNE_HUMANMINT9404514 details
GRAB_HUMANPERF_HUMANHPRD, IntAct11911826 8770355 details
GRAB_HUMANEEA1_HUMANInnateDB21685908 details
GRAB_HUMANHSP74_HUMANBioGRID12874291 details
GRAB_HUMANACM3_HUMANHPRD11665980 details
GRAB_HUMANGRAB_HUMANHPRD11209755 details
GRAB_HUMANMPRI_HUMANHPRD11081635 details
GRAB_HUMANLMNB1_HUMANHPRD11331782 details
GRAB_HUMANPARP1_HUMANHPRD9586635 details
GRAB_HUMANGRIA3_HUMANHPRD11160179 details
GRAB_HUMANRB27A_HUMANHPRD11266473 details
GRAB_HUMANUBE4B_HUMANHPRD11802788 details
GRAB_HUMANXRCC4_HUMANHPRD12218164 details
GRAB_HUMANCASP9_HUMANHPRD1067155 8900201 9651578 details