Entity Details

Primary name HLAC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10321
EntryNameHLAC_HUMAN
FullNameHLA class I histocompatibility antigen, C alpha chain
TaxID9606
Evidenceevidence at protein level
Length366
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesHLA-C

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0002250 adaptive immune response
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0016032 viral process
GO:0030667 secretory granule membrane
GO:0030670 phagocytic vesicle membrane
GO:0031901 early endosome membrane
GO:0042605 peptide antigen binding
GO:0042612 MHC class I protein complex
GO:0043312 neutrophil degranulation
GO:0046977 TAP binding
GO:0050776 regulation of immune response
GO:0055038 recycling endosome membrane
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0070062 extracellular exosome
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001039 MHC class I alpha chain, alpha1 alpha2 domainsDomainDomain
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR010579 MHC class I, alpha chain, C-terminalDomainDomain
IPR011161 MHC class I-like antigen recognition-likeDomainDomain
IPR011162 MHC classes I/II-like antigen recognition proteinFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR037055 MHC class I-like antigen recognition-like superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
177900 OMIMPsoriasis 1 (PSORS1)A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Disease susceptibility is associated with variants affecting the gene represented in this entry. Allele C*06:02 presents a melanocyte autoantigen ADAMTSL5 (VRSRRCLRL) to Valpha3S1/Vbeta13S1 TCR on CD8-positive T cells, and may trigger an autoimmune response against melanocytes.

Interactions

68 interactions

InteractorPartnerSourcesPublicationsLink
HLAC_HUMANB2MG_HUMANBioGRID, HPRD, IntAct, MINT10429675 2450918 26186194 27649529 28514442 28546555 details
HLAC_HUMANMPIP1_HUMANBioGRID, IntAct21988832 details
HLAC_HUMANYBOX1_HUMANBioGRID, IntAct21988832 details
HLAC_HUMANTANK_HUMANBioGRID, IntAct21988832 details
HLAC_HUMANTMG4_HUMANBioGRID, IntAct21988832 details
HLAC_HUMANBATF2_HUMANBioGRID, IntAct21988832 details
HLAC_HUMANKI2S4_HUMANHPRD, IntAct19858347 9521070 details
HLAC_HUMANKI2L1_HUMANBioGRID, HPRD, IntAct10429675 10820396 11009104 11163076 11323700 12454284 12794140 18624290 19858347 28546555 9378975 9686591 9768753 details
HLAC_HUMANKI2L3_HUMANBioGRID, HPRD, IntAct10497191 18322206 19858347 8692965 9768753 details
HLAC_HUMANKI2L2_HUMANBioGRID, HPRD, IntAct10190900 10850706 18322206 details
HLAC_HUMANKI2S1_HUMANHPRD, IntAct18624290 28546555 7650491 9464792 details
HLAC_HUMANLIRB2_HUMANDIP17056715 details
HLAC_HUMANKI2S5_HUMANIntAct28685972 details
HLAC_HUMANGP182_HUMANBioGRID, MINT28298427 details
HLAC_HUMANGPR37_HUMANBioGRID, MINT28298427 details
HLAC_HUMANNPSR1_HUMANBioGRID, MINT28298427 details
HLAC_HUMANOPRX_HUMANBioGRID, MINT28298427 details
HLAC_HUMANNAL12_HUMANI2D32226298 details
HLAC_HUMANLIRB1_HUMANBioGRID, HPRD12853576 details
HLAC_HUMANHLAC_HUMANBioGRID12794140 details
HLAC_HUMANCD8A_HUMANBioGRID, HPRD10809759 12899833 details
HLAC_HUMANKI2S2_HUMANBioGRID, HPRD11172020 details
HLAC_HUMANJIP2_HUMANBioGRID25814554 details
HLAC_HUMANPSA6_HUMANIntAct17353931 details
HLAC_HUMANMOES_HUMANIntAct17353931 details
HLAC_HUMANTHIL_HUMANIntAct17353931 details
HLAC_HUMANSEP15_HUMANIntAct17353931 details
HLAC_HUMANRHPN2_HUMANIntAct17353931 details
HLAC_HUMANMCM3_HUMANIntAct17353931 details
HLAC_HUMANGSTM3_HUMANIntAct17353931 details
HLAC_HUMANPSME3_HUMANIntAct17353931 details
HLAC_HUMANSYSC_HUMANIntAct17353931 details
HLAC_HUMANLKHA4_HUMANIntAct17353931 details
HLAC_HUMANNUDC_HUMANIntAct17353931 details
HLAC_HUMANHLAA_HUMANBioGRID, IntAct17353931 26186194 28514442 details
HLAC_HUMANPIN1_HUMANIntAct17353931 details
HLAC_HUMANRN213_HUMANIntAct17353931 details
HLAC_HUMANANM1_HUMANIntAct17353931 details
HLAC_HUMANPSMD6_HUMANIntAct17353931 details
HLAC_HUMANUGGG1_HUMANIntAct17353931 details
HLAC_HUMANEFTU_HUMANIntAct17353931 details
HLAC_HUMANPCBP1_HUMANIntAct17353931 details
HLAC_HUMANEIF3F_HUMANIntAct17353931 details
HLAC_HUMANCBR1_HUMANIntAct17353931 details
HLAC_HUMANMARE1_HUMANIntAct17353931 details
HLAC_HUMANPCNA_HUMANIntAct17353931 details
HLAC_HUMANPSB4_HUMANIntAct17353931 details
HLAC_HUMANTIF1B_HUMANIntAct17353931 details
HLAC_HUMANPYRG1_HUMANIntAct17353931 details
HLAC_HUMANGANAB_HUMANIntAct17353931 details
HLAC_HUMANCPSF5_HUMANIntAct17353931 details
HLAC_HUMANAATM_HUMANIntAct17353931 details
HLAC_HUMANGUAA_HUMANIntAct17353931 details
HLAC_HUMANHLAB_HUMANBioGRID, IntAct17353931 26186194 28514442 details
HLAC_HUMANPSA2_HUMANIntAct17353931 details
HLAC_HUMANEIF3L_HUMANIntAct17353931 details
HLAC_HUMANCLH1_HUMANIntAct17353931 details
HLAC_HUMANCALM2_HUMANIntAct17353931 details
HLAC_HUMANIMDH2_HUMANIntAct17353931 details
HLAC_HUMANKI3S1_HUMANIntAct27649529 details
HLAC_HUMANMD2L2_HUMANBioGRID, IntAct, UniProt26186194 28514442 29656893 30022168 details
HLAC_HUMANDISC1_HUMANIntAct31413325 details
HLAC_HUMANBIP_HUMANBioGRID, HPRD7957306 details
HLAC_HUMANTAP2_HUMANBioGRID, HPRD9551969 details
HLAC_HUMANRN139_HUMANBioGRID19720873 details
HLAC_HUMANST7_HUMANBioGRID29395067 details
HLAC_HUMANCALR_HUMANHPRD8769474 details
HLAC_HUMANTPSN_HUMANHPRD8769474 details